Read some background on PFOA and Teflon here.
A couple of years ago DuPont and other perfluorochemical industries were dismissing evidence of PFOA-caused cancer in rats, saying it was due to peroxisome proliferation in rats, which some argue isn’t relevant to humans. However, PFOA may have other mechanisms of action (disrupting thyroid hormones, gap junctions, and estradiol among them). You can read more about the evidence in this EWG submission to the EPA. Well, EPA must not have payed too much attention to those other mechanisms because they basically ignored them and wanted to discount the cancer. In fact, they didn’t do a cancer risk assessment at all. The EPA’s draft risk assessment isn’t very good but it does contain most of the background info if you’re interested.
Speeding forward to now, we have a paper in EHP showing that PFOA causes liver cancer in trout without causing peroxisome proliferation. In fact, it finds that PFOA administration leads to changes similar to, you guessed it, estradiol.
Gee, look how that turned out. Not as if a scientist should need convincing of this but…Never ignore data, it will turn around and make you look like a fool someday.