Angry Toxicologist

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A paper just published in Tox Sci shows that PFOS (the chemical that used to be the prime ingredient in Scotchgard) suppresses the immune system at levels, that didn’t cause noticeable toxicity that are same as what are found in the general population. Great. So, basically, many people in the US who show no other…

I’m waiting around for a meeting (about animal testing!) and thought I’d share a few things that I’ve been thinking about. 1) While we’re not going to stop using animals for testing in a long time it is a good idea to reduce them where we can and where industry and the public (at-large; I…

The Post really screwed this one up, not so much because they took a side on an issue in news piece (this is close to an opinion piece), but because it gets so much wrong and doesn’t even address the rest of the story. Issue 1: Science will save them! I’ve been over this before,…

There is a animal testing karmic pass up in the exhibition hall! I’ll post again when I return from my ego trip. PS Since it’s tangentally related, I’m going to use the opportunity to express some outrage at what the Chinese are saying about the Dalai Lama and doing to Tibetans. @#$@% $#%&^# $%#!

The poster sessions were largely a bust yesterday but I did come across a couple of interesting ones: 1) Definitive evidence that it was the melamine + cyuranic acid that caused toxicity in animals (by creating crystals inside the kidney). As I’ve noted before, neither is very toxic on it’s own. Not a surprise but…

In one of the sessions today there was a fantastic talk by Dr Dolinoy. Here are my notes with some explainations where needed: Epigenetics (this is where you affect gene expression by means other than damaging DNA, messing with transcription or translation of DNA/RNA, for instance). If you give murine dams (mice mothers) genestein (a…

Gee, I bet you’re pumped, right? I’ll be doing little updates now and then if I hear anything interesting. The opening lecture was by Dr Lee Hartwell (2001 Nobel Laureate) on science – particularly toxicology, of course – in the 21 century. There were a couple of interesting points that he made, particularly on how…

From the non-news that’s news’ department, Reuters reproted on a study that showed that ~15% of patients who took Sutent, a kidney and cancer drug, developed heart failure. Dr Melinda Telli presented information on 48 patients who took Sutent at an American Society of Clinical Oncology. You’d think this was new information the way it’s…

For those of you in any field that deals with health, you may know this feeling. Fortunately this is rare but in the past two weeks I’ve been completely exasperated at 3 different meetings and discussions I’ve been to. Without going into specifics, I’d like to say that as a group, us scientists are a…

Is this about a better environment, animal welfare or about better drug development? Take a guess. Yesterday NIEHS (National Institute of Environmental Health Sciences) had a little symposium on animal testing to celebrate the 10th year of ICCVAM (Interagency Coordinating Committee on the Validation of Alternative Methods) – gotta love the gov’t and their acronyms.…