Let's talk about the ethics of reproductive cloning.
Erin explained in the cloning kick-off post:
The word cloning refers to a procedure called somatic cell nuclear transfer (SCNT), where the nucleus of an unfertilized female egg is removed and replaced with the genetic nucleus of a body cell. This clonal embryo is then prompted to grow by cues in the cytoplasm of the egg.Reproductive cloning refers to the procedure of taking this product and implanting it in a womb to gestate. However, the scientific community considers this practice largely unethical to carry out on humans. In animal models the success rate of this procedure is very low due to biological restraints as has been shown with animal models like Dolly the Sheep. Scientists failed upwards of 300 times before experiencing successful implantation, gestation and birth with the resulting Dolly. Additionally, Dolly died at a relatively early age, although it is uncertain as to exactly why.
As I read it, the main objection scientists have to reproductive cloning at present is that we haven't really got it working yet. The success rate from start to live birth (in the mammals in which reproductive cloning has so far succeeded) is well below what can be expected from current in vitro fertilization techniques, and the shorter life span (and poorer health) of the clone offspring do not recommend cloning to the prospective human parent. It would not be ethical to go to all that trouble to birth a clone just to have him or her die young (after a life that might not be so enjoyable).*
But in the event that these technical issues are worked out -- that techniques are refined to the point that the cloned offspring would have every expectation of good health and a normal life span -- would the scientific community deem reproductive cloning an ethical option for humans? Would the community of non-scientists find it ethical?
Reproductive cloning captures the imagination. Rather than going through the whole genetic roulette inherent in ovum-sperm speed dating, why not opt for an offspring who is a known quantity -- as close to a chip off the old block (whether that block be Mom, Dad, a sibling, or a celebrity donor like Stephen Colbert) as you're likely to get?
There are some reasons people might be fearful of reproductive cloning that are not well grounded on facts. But I think there are other reasons why we ought to be extremely cautious about widespread use of reproductive cloning.
First, the objections I think are not well grounded.
Because a clone is made from someone else's DNA, it won't have its own identity.
Our DNA has an awful lot to do with the people we are (since as people, we are also human organisms), but identical DNA does not make for human beings identical in all their particulars.
Just ask my nieces, identical twins who have quite distinct personalities. Indeed, my nieces are likely more similar to each other, biologically speaking, than a DNA donor and a clone would be: they gestated in the same womb at the same time. (On top of that, growing up in the same household, going to the same school, etc., my nieces share a great deal in terms of their environment -- and environment has a lot to do with how our genes are actually expressed.)
Given that we don't view identical twins as a risk to personhood or individuality, we shouldn't think that the very fact of having a DNA-twin out there in the world is a problem for the personhood or individuality of a clone.
It's wrong for parents to try to make a child in their own image.
Something about electing to have a child who is a carbon copy of one's self can seem creepy and narcissistic.
But guess what: there are parents making babies the old fashioned way who want to see themselves reproduced in their offspring. These parents may be counting on their totally awesome genes to be dominant. Whether they are or not, these parents may also do what they can to create an environment where junior can grow up to be a violin virtuoso or a soccer star just like Dad or Mom.
The very fact that it matters enough to couples struggling with infertility to have their "own" children (indeed, that it matters enough that they will endure lengthy, expensive, and physically difficult fertility treatments) indicates that seeing one's genes carried on is not a completely bizarre thing to value. If we were really committed to the idea that it was wrong to make children in our own image, we would have instituted a system under which kids were raised by adults who were not their genetic relatives.
Because they're made in the lab, clones won't have souls.
Tell it to all the kids born as a result of IVF. They seem to be doing as well as anyone else.
Even though I don't think these worries are actually much to worry about, I would be nervous about widespread use of safe and effective reproductive cloning of humans. I'd be concerned about the effect it might have on our gene pool, largely because I'm not convinced that decisions that seem rational at the individual level will aggregate to results that are good for the population.
In the extreme, if parents were choosing the DNA of their offspring in an effort to produce a child with "the best" available genetic endowment, widely shared views of what "the best" looks like could result in a lot of clones from the same source material. When I was in grade school, there were four Jennifers in my class. In a grade school of the future, we might encounter four Jennifer Aniston clones in a class (and six Angelinas, and a bunch of Brads). And in the short term, if the main selection pressures you kid needs to withstand revolve around looking like a star and displaying some talent for acting, maybe that's OK. But there may be a lot of valuable genetic material hiding in the folks who don't look like they belong on the cover of US Weekly that may drop out of the pool.
At some point, especially if our environment changes in some subtle but significant way, we may need those genes. If they drop out of the pool, we may be in trouble.
This is a tough thing for us to wrap our minds around, as attached as we are both to our right to make all kinds of choices for ourselves and our commitment to make life as good for our kids as we can. Our individual choices -- choices that seem like the best choices when taken on their own -- can add up to bad outcomes. We can see something like evidence for this by looking at the gender imbalance in China that seems to have resulted from the One-Child policy in a society where boy-children are valued more than girl-children. Given the choice to carry only one child to term, it might seem perfectly rational to choose a boy -- choosing a girl would be choosing a child who would have a harder time of it in the world you were bringing her into.
But if too many individual parents make this same rational calculation, twenty years down the road, all those sons are going to have a heck of a time finding wives.
It's hard to predict exactly what kind of chickens might come home to roost if reproductive cloning became a common means of human reproduction. But I'm betting their talons could do some damage. Just in case the technologies for reproductive technology get a whole lot better, I think we need to make sure that we think about what we should be doing to maintain a healthy diversity in our shared gene pool.
________
*Undoubtedly, this line of reasoning raises the question of whether it is ethical to carry to term any child with a condition that could make his or her life painful and short. Since scientists aren't directly involved in most of these pregnancies, they get to sidestep the question.




Comments
For me, one of the biggest concerns for reproductive cloning is abuses of the clones. I'd worry about the cloning of people who have demonstrated, for example, a willingness to take abuse without complaint (for example, people with low IQs who don't understand that they're being abused), and using them to work in dangerous or undesirable jobs. Or cloning people with a history of violence, and using them to populate an army (national or otherwise).
Maybe those possibilities are a little far out, I don't know. But history has shown that people with the most power (i.e., ability to take advantage of technologies, such as cloning) are often also those with the fewest scruples...
Posted by: Dr. Kate | December 5, 2008 2:32 PM
Both those concerns are pretty much ruled out by anti-slavery laws.
Posted by: rpsms | December 5, 2008 5:54 PM
I suspect that anyone who attempted to build a compliant workforce by cloning people with the desired personality traits would be in for a big surprise. Like identical twins, these biologically "identical" individuals would probably still wind up with a range of personality traits.
Posted by: Julie Stahlhut | December 6, 2008 11:17 AM
I dunno. I guess my ethical question would be more along the lines of, "How ethical is it to pour gazillions of $$$, both private and public, into figuring out how to make your own personal DNA replicant instead of helping the many millions of existing children in foster/state care/orphanages?"
I realize that many parents do currently have the whole "it's different when it's your own" thing going on in their heads, but seriously...I do think that should be a disqualifier for parenting. Liking children in general should be a prerequisite of parenting, but unfortunately biology doesn't work that way. Still, just because lots of people do it, doesn't make it right. And I've often wondered how many infertile couples would remain so frantic about having their very own pregnancy if they were on an antidepressant/antipsychotic; it seems like being frantic and obsessive about getting pregnant is an "acceptable" thing for women to do, even when it verges into behavior that would otherwise be considered pathological.
If we were really committed to the idea that it was wrong to make children in our own image, we would have instituted a system under which kids were raised by adults who were not their genetic relatives.
Yeah...I went to boarding school. It actually worked out pretty well, all things considered. Did you ever read Charlotte Perkins Gilman's Herland? She posited the idea that children should be raised by professional child psychologists, while their biological parents go back to work after the kid was on solid food. Our foster system is so overwhelmed that we can't take care of kids who are really being badly abused, nevermind all the children whose parents fall into the grey area of "neglectful" to "barely competent to tie own shoes." So I can't see that idea flying too well. But as a hypothesis, it's not a bad one, and one that many people do avail themselves of on the far ends of the socioeconomic spectrum, with varying degrees of success.
Posted by: Lora | December 6, 2008 12:00 PM
Ethically, the issues you raise are valid.
Given that we would naturally tend to want to clone happy, healthy children, what's the guarantee that we can do it any better over the long term than nature is already doing now?
One answer would be a hard look at what's ethical to go after with cloning and what isn't.
A fairly clear-cut case may be a mother who has a heritable genetic disease she does not want to pass onto her child. If the genetic factors causing the disease were known and curable, it seems the humane thing to do to not risk the life of her child.
Other scenarios are much more messy. Wanting a knock-out super-fox daughter that is (hopefully) genetically preprogrammed to be a major Hollywood star has a host of problems. What about the child's free will? What if Darling decides she wants to be a mathematician? Or what if she rebels against being "Darling" and dresses to hide her beauty, or even elects reconstructive surgery with the sole intent of making herself less attractive so she can have a normal life?
Where is the line between a genetic intervention that's ethical for health reasons and one that's frivolous for cosmetic purposes? Who will decide such issues?
What's clear is that we won't be able to keep staving off facing such issues for maybe more than one or two generations, because by then, we'll have the science in place to accomplish those things. And you can bet there will certainly be wealthy customers out there willing to pay for the procedures.
Or worse, some innovative genius will patent a highly affordable procedure for genetic manipulation. If that happens, we'll be pining for the good ol' days when our worst problem was crowd control at WalMart.
Posted by: yogi-one | December 6, 2008 6:05 PM
I think the comments above raise the need for an important distinction, between three questions:
a) how justified is a *particular* instance of cloning?
b) is cloning ever justified?
c) is promoting or funding cloning research a good idea?
I raise this distinction (not exactly in those words) in this short piece I wrote a few years back:
"Yes, Human Cloning Should be Permitted"
http://rcpsc.medical.org/publications/annals/vol33-7_e/cloning.php
(Just to be clear: the title of the piece is intended to be provocative. It's not really an argument that cloning is a great idea, just a claim that the *existing* arguments *against* cloning are mostly terrible ones.)
Posted by: Chris MacDonald | December 8, 2008 12:51 PM