Medicine

Five kids in the first trial. Then eleven. Now thirty (ultimately 39): Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia Slowly but surely, HIV genetically modified to genetically modify relapsed acute lymphoblastic leukemia (ALL) patients T-cells are prolonging (saving?) kids lives. Ive written about this treatment a couple times before: ‘Dismal prognosis’ with…

After having written about how the Society for Integrative Oncology (SIO) has promoted guidelines for cancer patients that are—shall we say?—less than scientifically rigorous, I was immediately confronted with just what we face in academic medicine when it comes to the infiltration of quackery, or, as I like to call it, quackademic medicine. It came…

Last week, the US Food and Drug Administration published a final rule that updates requirements for what prescription-drug information must disclose about potential effects for pregnant and breastfeeding women and their babies. And last month, the agency released Drug Trials Snapshots, which is part of a pilot project to help consumers learn more about the clinical trials upon which new drugs’ approvals are based.

Last week, I discussed a monograph published in the Journal of the National Cancer Institute Monographs entitled Clinical Practice Guidelines on the Use of Integrative Therapies as Supportive Care in Patients Treated for Breast Cancer. As you might remember, I was completely unimpressed. However, those guidelines were not the only thing in that particular JNCI…

For some reason, pop news became enamored with this paper last month (unfortunately while I was away at a conference): HIV infection en route to endogenization: two cases Inexplicable media frenzy– Scientists find mechanism for spontaneous HIV cure French scientists find genetic mechanism by which two men were spontaneously cured of HIV. HIV discovery offers…

If there’s one thing about having a demanding day job, it’s that the cranks usually have the advantage. They can almost always hit first when a news story comes out that they can spin to attack their detested science. On the other hand, it usually ensures that by the time I get home, have dinner,…

Granted this is not comparative physiology, I thought this study was really interesting. Research has shown that exposure of developing embryos to caffeine in utero can alter the expression of genes in the heart leading to changes in how the heart develops and functions in adult animals. New research from the University of Florida published in…

I write about lots of things on ERV, but I didnt anticipate ever getting to the point where I can write new blog posts on new publications by cutting and pasting from old blog posts on old papers… Lots of news outlets have been talking about this new paper: Impact of HLA-driven HIV adaptation on virulence in…

The GMO debate hosted by Intelligent Squared was excellent and informative. I admit I learned things from listening and that’s always a bonus, but it’s worth watching to see the “respectable” arguments against GMO posed and dealt with very effectively by the pro-side in this debate. Spoiler alert, the pro-GMO side spanked the anti-GMO, going…

Cancer cure testimonials due to alternative medicine have been a staple of this blog since its very inception. Unfortunately, another staple of this blog since very early on has included stories of children with cancer whose lives have been endangered when their their parents refuse effective cancer therapy for their cancer, in particular chemotherapy. The…