A Blog Around The Clock

The Molecular Anatomy of Spontaneous Germline Mutations in Human Testes:

The frequency of Apert syndrome mutations is 100-1,000 times higher than expected from average mutation rates, and it is due to positive selection in the testis increasing the frequency of germ cells carrying the defect.

Enlightening Energy Parasitism by Analysis of an ATP/ADP Transporter from Chlamydiae:

This paper explores the functional basis of how the intracellular P. amoebophila manages to effectively exploit the energy pool of its host cell by using the nucleotide transporter PamNTT1.

Emergence of Large-Scale Cell Morphology and Movement from Local Actin Filament Growth Dynamics:

Mathematical modeling predicts global modifications of the shape and behavior of migrating cells from knowledge of detailed multiscale protein interactions.

Qualitative Research: Understanding Patients’ Needs and Experiences:

Why do up to half of all patients with tuberculosis (TB) fail to adhere to drug treatment [1]? The answer to this question is a matter of life and death, since nonadherence contributes to disease relapse and mortality.

Setting Priorities in Child Health Research Investments for South Africa:

This paper aims to define health research priorities in South Africa, where it is estimated that nearly 100,000 children under 5 years of age still die each year.