Nick Matzke wrote an excellent update on what we know about the Origin of Life:
Here is a short list of things we have discovered or confirmed in the last 50 years or so pertaining to the origin of life. In my opinion all of these points have reached high enough confidence that they are unlikely to change much with future discoveries, and our confidence in them does not depend in uncertainties in the remaining unanswered questions.
I agree with him that, in confrontations with Creationists, we should not secede the origin of life to then (i.e.., “evolution only covers what happens once Life already exists). When I teach BIO101, I always cover the current ideas about the Origin of Life, and Nick’s post will be helpful for me next time to get my lecture up to date (and perhaps give it as “supplemental reading” to the students).