Clock Tutorials

A Blog Around The Clock

Category archives for Clock Tutorials

Two interesting papers came out last week [from the Archives – click on the clock logo to see the original post], both using transgenic mice to ask important questions about circadian organization in mammals. Interestingly, in both cases the gene inserted into the mouse was a human gene, though the method was different and the…

This post is a modification from two papers written for two different classes in History of Science, back in 1995 and 1998. It is a part of a four-post series on Darwin and clocks. I first posted it here on December 02, 2004 and then again here on January 06, 2005:

A Pacemaker is a Network

This is going to be a challenging post to write for several reasons. How do I explain that a paper that does not show too much new stuff is actually a seminal paper? How do I condense a 12-page Cell paper describing a gazillion experiments without spending too much time on details of each experiment…

This post about the origin, evolution and adaptive fucntion of biological clocks originated as a paper for a class, in 1999 I believe. I reprinted it here in December 2004, as a third part of a four-part post. Later, I reposted it here.

Everything Important Cycles

Microarrays have been used in the study of circadian expression of mammalian genes since 2002 and the consensus was built from those studies that approximately 15% of all the genes expressed in a cell are expressed in a circadian manner. I always felt it was more, much more. I am no molecular biologist, but I…

This post, originally published on January 16, 2005, was modified from one of my written prelims questions from early 2000.

This is a repost of a May 29, 2008 post:

This is the third in the series of posts designed to provide the basics of the field of Chronobiology. This post is interesting due to its analysis of history and sociology of the discipline, as well as a look at the changing nature of science. You can check out the rest of Clock Tutorials here.

The Clock Metaphor

Chad wrote a neat history of (or should we say ‘evolution of’) clocks, as in “timekeeping instruments”. He points out the biological clocks are “…sort of messy application, from the standpoint of physics…” and he is right – for us biologists, messier the better. We wallow in mess, cherish ambiguity and relish in complexity. Anyway,…

This is the second in the series of posts designed to provide the basics of the field of Chronobiology. See the first part: ClockTutorial #1 – What Is Chronobiology and check out the rest of them here – they will all, over time, get moved to this blog.