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I am the Online Community Manager at PLoS-ONE (Public Library of Science). My job is to try to motivate you to comment on the papers there. My scientific specialty is chronobiology (circadian rhythms and photoperiodism), with additional interests in comparative physiology, animal behavior and evolution. You can contact me at: Coturnix@gmail.com

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Dictionary of Circadian Physiology

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Bloggie Stuff

Clock Tutorials:

Chossat's Effect in humans and other animals

This April 09, 2006 post places another paper of ours (Reference #17) within a broader context of physiology, behavior, ecology and evolution. The paper was a result of a "communal" experiment in the lab, i.e., it was not included in...

Some hypotheses about a possible connection between malaria and jet-lag

Hypotheses leading to more hypotheses (from March 19, 2006 - the Malaria Day):...

Lithium, Circadian Clocks and Bipolar Disorder

You probably realize by now that my expertise is in clocks and calendars of birds, but blogging audience forces me to occasionally look into human clocks from a medical perspective. Reprinted below the fold are three old Circadiana posts about...

Everything Important Cycles

Microarrays have been used in the study of circadian expression of mammalian genes since 2002 and the consensus was built from those studies that approximately 15% of all the genes expressed in a cell are expressed in a circadian manner....

A Pacemaker is a Network

This is going to be a challenging post to write for several reasons. How do I explain that a paper that does not show too much new stuff is actually a seminal paper? How do I condense a 12-page Cell...

The Clock Metaphor

Chad wrote a neat history of (or should we say 'evolution of') clocks, as in "timekeeping instruments". He points out the biological clocks are "...sort of messy application, from the standpoint of physics..." and he is right - for...

Basics: Biological Clock

Considering I've been writing textbook-like tutorials on chronobiology for quite a while now, trying always to write as simply and clearly as possible, and even wrote a Basic Concepts And Terms post, I am surprised that I never actually defined...

Seasonal Affective Disorder - The Basics

This is an appropriate time of year for this post (February 05, 2006)......

Clock Tutorial #16: Photoperiodism - Models and Experimental Approaches

This post (written on August 13, 2005) describes the basic theory behind photoperiodism and some experimental protocols developed to test the theory....

Clock Tutorial #15: Seasonality

This post (click on the icon) was originally written on May 07, 2005, introducing the topic of neuroendocrine control of seasonal changes in physiology and behavior....

Clock Tutorial #14: Interpreting The Phase Response Curve

This is the sixth post in a series about mechanism of entrainment, running all day today on this blog. In order to understand the content of this post, you need to read the previous five installments. The original of this...

Clock Tutorial #13: Using The Phase Response Curve

This is the fifth post in a series about mechanism of entrainment. Originally written on April 11, 2005....

Clock Tutorial #12: Constructing the Phase Response Curve

The fourth post in the series on entrainment, originally written on April 10, 2005, explains the step-by-step method of constructing a PRC....

Clock Tutorial #11: Phase-Shifting Effects Of Light

The third post in the series on entrainment, first written on April 10, 2005, starts slowly to get into the meat of things...As always, clicking on the spider-clock icon will take you to the site of the original post....

Clock Tutorial #10: Entrainment

This is the second in a series of posts on the analysis of entrainment, originally written on April 10, 2005....

Clock Tutorial #9: Circadian Organization In Japanese Quail

Going into more and more detail, here is a February 11, 2005 post about the current knowledge about the circadian organization in my favourite animal - the Japanese quail....

Clock Tutorial #8: Circadian Organization In Non-Mammalian Vertebrates

This post was originally written on February 11, 2005. Moving from relatively simple mammalian model to more complex systems....

Clock Tutorial #7: Circadian Organization in Mammals

This February 06, 2005 post describes the basic elements of the circadian system in mammals....

Clock Tutorial #6: To Entrain Or Not To Entrain, That Is The Question

This post from February 03, 2005 covers the basic concepts and terms on entrainment. This is also the only blog post to date that I am aware of that was cited in a scientific paper....

ClockTutorial #5: Circadian Organization

I wrote this post back on February 02, 2005 in order to drive home the point that the circadian clock is not a single organ, but an organ system comprised of all cells in the body linked in a...

Clock Tutorial #4: On Methodology

I wrote this post back on January 23, 2005. It explains how clock biologists think and how they design their experiments:...

Clock Tutorial #3c - Darwin On Time

This post is a modification from two papers written for two different classes in History of Science, back in 1995 and 1998. It is a part of a four-post series on Darwin and clocks. I first posted it here...

ClockTutorial #3b - Whence Clocks?

This post about the origin, evolution and adaptive fucntion of biological clocks originated as a paper for a class, in 1999 I believe. I reprinted it here in December 2004, as a third part of a four-part post. Later, I...

ClockTutorial #3a - Clock Evolution

This post, originally published on January 16, 2005, was modified from one of my written prelims questions from early 2000....

ClockTutorial #2a: Forty-Five Years of Pittendrigh's Empirical Generalizations

This is the third in the series of posts designed to provide the basics of the field of Chronobiology. This post is interesting due to its analysis of history and sociology of the discipline, as well as a look...

ClockTutorial #2: Basic Concepts and Terms

This is the second in the series of posts designed to provide the basics of the field of Chronobiology. See the first part: ClockTutorial #1 - What Is Chronobiology and check out the rest of them here - they...

ClockTutorial #1 - What Is Chronobiology

This is the first in a series of posts from Circadiana designed as ClockTutorials, covering the basics of the field of Chronobiology. It was first written on January 12, 2005:...

Phase-Response Curves to Melatonin

NBM found an excellent online article (which I have seen before but I forgot) depicting Phase-Response Curves (PRC) to injections of melatonin in humans, rodents and lizards. Note how the shape is roughly opposite to that of a PRC to...

Clock Tutorial #9: Circadian Organization In Japanese Quail

Going into more and more detail, here is a February 11, 2005 post about the current knowledge about the circadian organization in my favourite animal - the Japanese quail....

Clock Tutorial #8: Circadian Organization In Non-Mammalian Vertebrates

This post was originally written on February 11, 2005. Moving from relatively simple mammalian model to more complex systems....

Clock Tutorial #7: Circadian Organization in Mammals

This February 06, 2005 post describes the basic elements of the circadian system in mammals....

ClockTutorial #5: Circadian Organization

I wrote this post back on February 02, 2005 in order to drive home the point that the circadian clock is not a single organ, but an organ system comprised of all cells in the body linked in a...

Clock Tutorial #16: Photoperiodism - Models and Experimental Approaches

This post (written on August 13, 2005) describes the basic theory behind photoperiodism and some experimental protocols developed to test the theory....

Clock Tutorial #15: Seasonality

This post (click on the icon) was originally written on May 07, 2005, introducing the topic of neuroendocrine control of seasonal changes in physiology and behavior....

Clock Tutorial #14: Interpreting The Phase Response Curve

This is the sixth post in a series about mechanism of entrainment, running all day today on this blog. In order to understand the content of this post, you need to read the previous five installments. The original of this...

Clock Tutorial #13: Using The Phase Response Curve

This is the fifth post in a series about mechanism of entrainment. Originally written on April 11, 2005....

Clock Tutorial #12: Constructing the Phase Response Curve

The fourth post in the series on entrainment, originally written on April 10, 2005, explains the step-by-step method of constructing a PRC....

Clock Tutorial #11: Phase-Shifting Effects Of Light

The third post in the series on entrainment, first written on April 10, 2005, starts slowly to get into the meat of things...As always, clicking on the spider-clock icon will take you to the site of the original post....

Clock Tutorial #10: Entrainment

This is the second in a series of posts on the analysis of entrainment, originally written on April 10, 2005....

Clock Tutorial #6: To Entrain Or Not To Entrain, That Is The Question

This post from February 03, 2005 covers the basic concepts and terms on entrainment. This is also the only blog post to date that I am aware of that was cited in a scientific paper....

Clock Tutorial #4: On Methodology

I wrote this post back on January 23, 2005. It explains how clock biologists think and how they design their experiments:...

ClockTutorial #2a: Forty-Five Years of Pittendrigh's Empirical Generalizations

This is the third in the series of posts designed to provide the basics of the field of Chronobiology. This post is interesting due to its analysis of history and sociology of the discipline, as well as a look...

ClockTutorial #2: Basic Concepts and Terms

This is the second in the series of posts designed to provide the basics of the field of Chronobiology. See the first part: ClockTutorial #1 - What Is Chronobiology and check out the rest of them here - they...

Basics: Biological Clock

Considering I've been writing textbook-like tutorials on chronobiology for quite a while now, trying always to write as simply and clearly as possible, and even wrote a Basic Concepts And Terms post, I am surprised that I never actually defined...

ClockTutorial #1 - What Is Chronobiology

This is the first in a series of posts from Circadiana designed as ClockTutorials, covering the basics of the field of Chronobiology. It was first written on January 12, 2005:...

Clock Tutorial #3c - Darwin On Time

Placing Darwin into the chronology of the history of Chronobiology.

Basics: Biological Clock

Considering I've been writing textbook-like tutorials on chronobiology for quite a while now, trying always to write as simply and clearly as possible, and even wrote a Basic Concepts And Terms post, I am surprised that I never actually defined...

(Non) Adaptive Function of Sleep

An article I really liked...

Clock Tutorial #16: Photoperiodism - Models and Experimental Approaches

This post describes the basic theory behind photoperiodism and some experimental protocols developed to test the theory.

Clock Tutorial #15: Seasonality

This post is introducing the topic of neuroendocrine control of seasonal changes in physiology and behavior.

Downloadable Database of Phase Response Curves

This post gives you links to further online resources and literature on entrainment and Phase-Response Curves, as well as a link to a database of PRCs so you can play with them yourself.

Clock Tutorial #14: Interpreting The Phase Response Curve

This is the sixth post in the series about mechanisms of circadian entrainment, running all day today on this blog. In order to understand the content of this post, you need to read the previous five installments.

Clock Tutorial #13: Using The Phase Response Curve

This is the fifth post in a series about mechanism of entrainment.

Clock Tutorial #12: Constructing the Phase Response Curve

The fourth post in the series on entrainment explains the step-by-step method of constructing a PRC.

Clock Tutorial #11: Phase-Shifting Effects Of Light

The third post in the series on entrainment starts slowly to get into the meat of things...

Clock Tutorial #10: Entrainment

This is the second in a series of posts on the analysis of entrainment, explaining the basics of what entrainment is and how it is studied.

Clock Tutorial #6: To Entrain Or Not To Entrain, That Is The Question

This post covers the basic concepts and terms on entrainment. It was cited as a reference in a scientific review paper.

Clock Tutorial #9: Circadian Organization In Japanese Quail

Going into more and more detail, here is a February 11, 2005 post about the current knowledge about the circadian organization in my favourite animal - the Japanese quail.

Clock Tutorial #8: Circadian Organization In Non-Mammalian Vertebrates

Moving from relatively simple mammalian model to more complex systems.

Clock Tutorial #7: Circadian Organization in Mammals

This post describes the basic elements of the circadian system in mammals.

ClockTutorial #5: Circadian Organization

The circadian clock is not a single organ, but an organ system comprised of all cells in the body linked in a hierarchical manner.

All Clocks All Week

As I announced last week, this week will be All Clocks All The Time. Why? First, I need to move some of the old posts from Circadiana over here, at a faster rate than I've been doing so far. Second,...

Clock Genetics - A Short History

A short post from April 17, 2005 that is a good starting reference for more detailed posts covering recent research in clock genetics.

Clock Tutorial #4: On Methodology

How clock biologists think and how they design their experiments.

ClockTutorial #3b - Whence Clocks?

Origin, Evolution, and Adaptive Function of Biological Clocks

ClockTutorial #3a - Clock Evolution

This post, originally published on January 16, 2005, was modified from one of my written p