My picks from ResearchBlogging.org

In case you missed them, these are my picks from ResearchBlogging.org's psychology and neuroscience categories. Neat stuff!

Also, I have a new column up on SEEDMAGAZINE.COM. This week I discuss the slow progress finding a cure for pancreatic cancer. Here's a taste:

So just how hard will it be for genome researchers to make headway against pancreatic cancer? Last March, Daniel MacArthur, a researcher of genetic variants that lead to disease, wrote an excellent post summing up the some of the difficulties of using DNA sequencing to identify disease risk. In a study led by Siân Jones, researchers discovered a mutation responsible for pancreatic cancer in a single patient, then confirmed the mutation's presence in 3 of 96 other patients with pancreatic cancer. The mutation was entirely absent from more than 1,000 people without the disease. So, in principle, anyone with this mutation is likely to develop cancer and should be closely monitored for the disease, right? And if we could find other similar mutations, we might actually be able to eradicate it...right?

So the story goes. Unfortunately, as MacArthur said, the investigators also found "a whole stack of red herrings." There were literally hundreds of abnormalities in the initial patient's genome, and only through a quirk of the cancer (the fact that the normal, non-mutated gene is disrupted in cancer cells but not healthy ones) were they able to find the mutation responsible for the disease.

I particularly like the artwork SEED created to accompany the column, which unfortunately will disappear from the front page tomorrow when a new article is posted. Check it out while you can here on the front page of SEEDMAGAZINE.COM.

More like this

Jones et al. (2009). Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene. Science DOI: 10.1126/science.1171202 A paper published online today in Science illustrates both the potential and the challenges of using large-scale DNA sequencing to identify rare genetic variants…
Cancer, we are told, is a disease of the genes. It originates in mutations in the DNA. But a paper published by a Weizmann Institute group in Cell Reports flips that idea sideways by about 90 degrees: For at least some types of the disease, the healthy, non-mutated version of a gene is no less of a…
In case you missed them, here are the posts I chose as "Editor's Selections" yesterday for ResearchBlogging.org. The amazing malleability of our body image. Volunteers felt real pain watching someone hurt a fake hand. Can we use EEG to predict whether an antidepressant will be effective? Maybe, but…
My column on SEEDMAGAZINE.COM today addresses the definition of "addiction." Does it make sense to lump all dependence on substances and even all habits under the umbrella of "dependence?" Here's a selection: We often think of true addicts as street junkies who prostitute themselves or steal from…