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The Corpus Callosum

The Corpus Callosum is an occasional journal of armchair musings, by a suburban, reality-based, slightly-left-of-center guy, who reserves the right to be highly irregular at times. Topics: social commentary, neuroscience, politics, science news. Mission: to develop connections between hard science and social science, using linear thinking and intuition; and to explore the relative merits of spontaneity vs. strategy.

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Corpus Callosum is written by a psychiatrist at a small community hospital somewhere in the USA. Email to cc.scienceblogger at gmail dot com.


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June 30, 2010

Tricks with Graphs: Deliberate Misinformation on Fox

Category: PoliticsPropagandaeconomy

From Media Matters:


0628-fncjoblosschart.jpg
It is difficult to understand how so many errors could be crammed into one simple chart, merely by accident.  It is even harder to understand how the artist could end up with a straight line, after incorporating numerous errors, unless it was an done with the intention of being misleading.

First, (problem #1) the Y-axis does not start at zero.  That is a fairly common error.  Sometimes it is done innocently, and a notice is posted.  For example, "Y-axis does not start at zero, to better show the change," or something like that.  OK. That's minor.  The Fed does the same thing.

Notice, though, that the title says "Job loss by quarter."  But (#2) the X-axis does not show quarters.  The X-axis also is not linear (#3).  December 2007 to September 2008 is 9 months (3 quarters), while March 2009 to June 2010 is 15 months (5 quarters). 

The biggest problem, though, (#4) is that the numbers on the line do not indicate job losses per quarter, or per any period-of-time. 

June 28, 2010

This Angle is Obtuse

Category: ChatterPolitics

Sharron Angle has said some pretty obtuse things before, but for the most part, I've resisted the temptation to comment.  But this one is a gem:

The 16-page flier, available at TPMM, accuses gay people (aka "sodomites", "perverts") of everything from child molestation, to serial murder, to debasing rodeos, to contaminating the water supply by exuding HIV. Blood libel, or urine libel, as the case may be.

I don't care about the water supply, or that other stuff. BUT DON"T MESS WITH OUR RODEOS.

June 26, 2010

Darwin Award Candidate

Category: Humor

image6616208x.jpgClearly, this man is a candidate for the Darwin Award.  K. Wayne McLeod has been charged -- posthumously -- with running a Ponzi scheme that victimized an estimated 260 law enforcement agents.

He deliberately solicited hundreds of people, all of whom have guns, all of whom know how to use their guns, and all of whom have access to information resources that can be used to locate other people.  He then did something that was guaranteed to piss every single one of them off. 

The outcome is not particularly surprising. 

SEC: Slain CEO Was Running Ponzi Scheme

The U.S. Securities and Exchange Commission today charged the estate of Florida investment firm executive K. Wayne McLeod with running a Ponzi scheme that victimized an estimated 260 law enforcement agents.

McLeod reportedly raised at least $34 million since 1988 by luring active and retired government employees to invest in the "FEBG Bond Fund" with false promises of annual returns between eight and 10 percent. McLeod operated the fund through the Federal Employee Benefits Group, Inc.

According to the SEC's complaint, McLeod wrote to investors, "With all of the Ponzi Scams going on around the world I wanted to insure you that this account is 100% secured by US Gov't Securities and the principal is never touched until liquidated."

The SEC alleges that the "FEBG Bond Fund" did not exist...

McLeod was found shot to death in his car in Jacksonville, Fla. Tuesday morning, four days after he sent an e-mail that notified his clients that he was closing the fund.


June 20, 2010

Father's Day Repast Repost

Category: Personal

(From five years ago!)

There is a restaurant called Pelagos.  The name means "from the sea," in Greek.  It is underground, but has a patio open to the sky.  A staircase leads from the sidewalk to the subterranean patio.  The is a metal fence along the sidewalk.  On the patio, there are tables with umbrellas.  Large windows provide a view of the patio, from inside the restaurant.  Looking out, a person might be fascinated by the geometrical shapes formed by the window frames, the the tables, the steps, and the fence; that person might also be happy to glimpse a bit of sky.

Except now it starts to rain.  Unhappy patrons rush in from the patio.  But some people had read the weather report, and stayed inside for their dinner.  

Inconspicuous, along one wall of Pelagos, sit three men, of three generations.  As is always true in this Universe, the three men sit arranged in a triangle.  

All speak English as their native language.  But the oldest learned Japanese; the middle, German; the youngest, Russian and Latin.  

As it happens, the Latin form of Pelagos is Pelagius.

The oldest of the men enjoyed hunting and fishing, but no longer can do these things; he reads about history and the human mind, appreciates fine wine, listens to jazz.  Raised in poverty, he used his intellect to complete an advanced education; then went on to build security for his family, and a good reputation for himself.  This stands in stark contrast to the earlier generations of this particular lineage.  The oldest moved up in society by trying to improve himself, never by trying to take advantage of others.

The middle-generation man never particularly enjoyed hunting or fishing; indeed, is not terribly fond of any sort of killing.  At times, he has been known to read about history, and the human brain.  He raises horses and builds computers.  Although proficient at photography, he never cared so much about music or other forms of art.  He drinks beer, but never more than 16 fluid ounces (about 500 milliliters). sometimes he pretends to like wine, but generally does not pretend much.  One of the reasons that he does not drink much alcohol is that he hopes, someday, to live up to the reputation that his father established for the family.  If you ask him, he'll say he does not care about his reputation.  That is not really true, but the reason he cares about his reputation, is that he wants a better life for subsequent generations.

It annoys him that the restaurant brings a 12-ounce bottle of beer, with a 10-ounce glass to put it in, but that is a minor point.  It annoys him more, that some people don't think for themselves.

The youngest, like his father, is proficient at photography; unlike his father, he prefers digital -- like most young people these days.  One summer, he rode a bicycle in China, after which his father posted the pictures on the Internet.  The youngest uses computers, can upgrade them, but mostly sees them as tools to be used for specific purposes; unlike his father, he is not terribly fond of the hardware side of things.  At a very young age, he wanted to be an ichthyologist, or maybe a limnologist; later, he got interested in history and political science.  In his honors calculus class, he wrote a term paper about public-key cryptography.  Folk music is one thing he cares about, although he has chosen to not develop his innate musical talent.  He'll be off to college soon.  After thoughtful consideration of his many interests, he now thinks he will study virology and immunology.  

The older and middle of the men have devoted a great deal of effort to alleviating the suffering of individuals.  The youngest has grander plans, as a young person should.  He would like to prevent the suffering of many; not limit himself to saving people one at a time.

They sit and enjoy their dinner.  They talk about things.  It is an ordinary time.  Perhaps none of the three will, individually, make a lasting impression on the course of human events.  However, geometry has a lesson for us: the triangle, expanded to three dimensions, can form an icosahedron.  Perhaps the lineage of the three men will, over time, manage to build something just as elegant.

But instead of looking forward, we now look back.  As we sift through history, we see that there have been many who would have changed the course of events for the better.  Sometimes, the geometry of the Universe permits this; sometimes, it impedes it.

History has a lesson for us.  As the Roman empire was crumbling, and the Dark Ages began, there was a great struggle among theologians.  They cast aside Plato, and with him, his beloved tetrahedron, cube, octahedron, and dodecahedron.  Worst of all, even the supremely elegant icosahedron was tossed back into the sea.  

They thought the cross would solve everything.  Alas, they could only think in two dimensions.

One of them dared to dissent.  He carried the peculiar name Pelagius.  He promoted the idea that humans are basically good, and that it is through their free choice of actions that they keep themselves good.

In contrast, the predominant view at the time was that of St. Augustine, who believed that humans were fundamentally tainted by the original sin, and any good they had, came from the grace of god. 

The geometry of the Universe was not kind to Pelagius, although ultimately he managed to avoid the worst of fates.  From Wikipedia:

When Alaric sacked Rome in 410, Pelagius fled to Carthage, where he came into further conflict with Augustine. His follower Coelestius was condemned by a church council there. Pelagius then fled to Jerusalem, but Augustine's followers were soon on his trail; Orosius went to Jerusalem to warn St Jerome against him. Pelagius succeeded in clearing himself at a diocesan synod in Jerusalem and a provincial one in Diospolis (Lydda ), though Augustine said that his being cleared at those councils must have been the result of Pelagius lying about his teachings.

Augustine's version of Pelagius's teachings about sin and atonement were condemned as heresy at the local Council of Carthage in 417.

Those are the people who told us to put away childish things.  Those are the people who cast aside the icosahedron as a mere trinket.  But it so doing, they brought us the Dark Ages.

The online Catholic Encyclopedia contains the following commentary about Pelagius:

Meanwhile the Pelagian ideas had infected a wide area, especially around Carthage, so that Augustine and other bishops were compelled to take a resolute stand against them in sermons and private conversations.
Imagine that, being infected with the notion that humans are fundamentally good.  Is it some kind of virus?

Outside Pelagos, it rained.  Those who had not familiarized themselves with local meteorology got soaked.  The three generations of men, well-acquainted with the Sciences, stayed dry.   One of them wants to study viruses.  Perhaps there is hope.

June 12, 2010

Tech Tip #9

Category: Chatter

This one is useful for very few persons. The story is this: I wanted to get one of those mats that goes under a treadmill, to protect the floor. So I went to Sears, where I got the treadmill, because I had seen an ad for the mat. Thirty dollars is what they wanted. Seemed overpriced. But that is what they want. Being a tad compulsive, I measured the treadmill's footprint before I left. The mat would have to be 40 inches wide and 72 inches long.

At the store, the mats -- all with the same brand name as the treadmill -- were all 36 inches wide. Would not do. So I get one off the shelf, get on my hands and knees, and compare it the the footprint of the floor model. It was just plain not going to work. I was just starting to fume a bit about a wasted trip. Then the lady walks up and asks, "are you OK?" Not "can I help you?" She probably thought I had tried out the treadmill and fallen off, or something like that. Ordinarily, a customer is not found on his hands and knees in the store.

I told her I was checking out the mat, and that it was not going to work. I was perfectly even-tempered, no hint of frustration. She said "No, it won't. Let me show you what will."

She walks me over the the hardware section and shows me these "anti-fatigue" mats, the kind that comes in big jigsaw-type sections that fit together into whatever footprint you want. They are on sale for ten dollars, for a pack of six pieces, which happens to be exactly the number of pieces needed for the footprint I want.

mat_500px.JPG

So the tip is this: no matter how frustrated you are, don't cuss at the salespeople until you give them a chance to solve the problem. Sometimes, they actually know what you need, where it is, and sometimes it is even cheaper than what you thought you were going to have to spend.

I have to say, I lost some respect for the NordicTrack brand, and gained a little for Sears. The Nordic Track website lists two mats, both 36x72, and both have negative user reviews. One comment states that the mat is too small for most the the equipment they sell. Overcharging people, for something that isn't going to work, is not a good business plan.

June 6, 2010

xkcd: Worst-Case Scenario

Category: HumorScience in the Media

XKCD usually is pretty good; this one, however, is a brillant commentary on science journalism. People forget that once an event has happened, the probability of that event is exactly 1, and the probability of all other outcomes is exactly zero. (Click image for full-size view.)

Worst-Case Scenario

(Source page.)

May 11, 2010

Another rTMS Update

Category: NeurosciencePsychiatry

Repetitive transcranial magnetic stimulation (rTMS) is  a treatment for major depression.  It was approved (PDF) by the FDA in 2008.  However, it has remained somewhat of a niche treatment.  Some providers remain unimpressed by studies of efficacy.  One problem is that most of the studies have been sponsored by the industry.  Often, the studies have used single-blind methodology. 

So now there is a published study, sponsored by the NIH, that used a good double-blind method.  It used a sham procedure that mimics the sensation of active treatment, while blocking the magnetic field.  It was a multicenter study that included 190 patients.  The conclusion: "Daily left prefrontal rTMS as monotherapy produced statistically significant and clinically meaningful antidepressant therapeutic effects greater than sham."  Sounds good, right?

Daily Left Prefrontal Transcranial Magnetic Stimulation Therapy for Major Depressive Disorder
A Sham-Controlled Randomized Trial

Arch Gen Psychiatry. 2010;67(5):507-516.

May 8, 2010

I Just Noticed

Category: Social Commentary

I just noticed this: the average workweek in the USA has declined to 34.1 hours (see the BLS report: Employment Situation Summary).   Last year, the average television viewing time increased to 151 hours per month, or 5.03 hours per day in a 30-day month, which comes out to  35.23 hours per week.  We now spend more time watching TV than we spend working.


April 26, 2010

Cryptococcus gattii: Outbreak due to climate change?

Category: MedicinePublic Health

National Geographic reports:

A new strain of hypervirulent, deadly Cryptococcus gattii fungus has been discovered in the United States, a new study says.

The outbreak has already killed six people in Oregon, and it will likely creep into northern California and possibly farther, experts say...

Cryptococcus infections in humans are hardly new.  And so far, the public health impact of the outbreak has been very low (understanding, of course, that the personal impact has been dreadful for a few). 

Cryptococcus is a genus of fungus, though, and it is rare for people to get serious fungal infections unless they are already ill with something else, or have compromised immunity due to age or some other factor.  The peculiar thing about Cryptococcus gattii is that it is causing serious infections in persons who were perfectly healthy. 

This poses two problems for the clinician.  For one, most clinicians in North America are unfamiliar with it, as it has not caused outbreaks here before.  That is, it has not been known to cause outbreaks here before.  Two, most clinicians would not suspect a fungal infection as the cause of symptoms in an otherwise healthy person.  It can be difficult to diagnose a condition, when the physician is thinking that the true cause is highly unlikely.

Even so, it appears that the diagnosis is not difficult to establish, once the appropriate tests are done:

Clinical presentation, diagnosis and management of Cryptococcus gattii cases: Lessons learned from British Columbia
Can J Infect Dis Med Microbiol. 2009 Spring; 20(1): 23-28.

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