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The Corpus Callosum

The Corpus Callosum is an occasional journal of armchair musings, by a suburban, reality-based, slightly-left-of-center guy, who reserves the right to be highly irregular at times. Topics: social commentary, neuroscience, politics, science news. Mission: to develop connections between hard science and social science, using linear thinking and intuition; and to explore the relative merits of spontaneity vs. strategy.

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Corpus Callosum is written by a psychiatrist at a small community hospital somewhere in the USA. Email to cc.scienceblogger at gmail dot com.


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Neuroscience:

Iloperidone, Approved For Treatment Of Schizophrenia

Category: Psychiatry

The new drug is called iloperidone; the brand name in the USA will be Fanapt.  It is yet another antipsychotic that blocks D2 and 5HT2 receptors.  Although there is no universally accepted way of classifying drugs into families, it will...

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Rethinking Alzheimer's Disease

Category: Neuroscience

A recent report refers to the increasing number of Alzheimer patient an "emergency."  Yet, despite an enormous amount of research, and a handful of drugs, we are not particularly close to having a robust intervention for this condition. Perhaps the...

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Poets On Prozac

Category: Psychiatry

Poets on Prozac is the short title of a book by psychiatrist-poet Richard M. Berlin, MD.  The full title is: Poets on Prozac: Mental Illness, Treatment, and the Creative Process.  Berlin was an associate professor of psychiatry at the University...

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Clozapine Augmentation with Lamotrigine

Category: Neuroscience

It is refreshing to see something like this.  Both drugs are available as generics, so the financial motivation for a study like this is not great.  But the clinical benefit could e substantial, albeit for a small subset of patients....

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Whole-Body Neuronal MRI

Category: Neuroscience

There is a short open-access article about whole-body neuronal MRI, in the most recent NEJM.  The authors describe a technique of visualizing peripheral nerves.  Normally, these are not seen very well on MRI.  This limits the usefulness of MR imaging...

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What Is Behavior?

Category: Psychiatry

Natalie Angier has another interesting article in the NYT.  In the article, she discusses the meaning of the word behavior.  Apparently, this all came from the realization that even standard works on the subject did not contain a "point-by-point definition." ...

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Update on Nav1.7

Category: Neuroscience

PhysioProf commented about this back in 2006 after Alex Palazzo 's post, A silent mutation affects pain perception? That post discussed mutations that affect pain perception.  Now, there is a bit more information available about potential commercial developments stemming from...

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Possible Genetic Link: Insomnia and Depression

Category: Psychiatry

This is one of those "interesting, wonder if it'll ever pan out" studies.  So far it has been presented at a meeting, but not published.   The study was summarized in an article on Medpage Today (free registration): APSS: Depression and...

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More Ado About Area 25

Category: Neuroscience

Some may recall Brodmann Area 25 (a part of the brain also known as the subgenual area or area subgenualis).  It was mentioned by Orli Van Mourik (Much Ado About Area 25) in 2006, and by me in 2008 (Update...

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Clozapine Response and Lipids: An Intriguing Correlation

Category: Psychiatry

(comic from kxcd) This post will discuss some findings about the factors that are correlated to clinical response to clozapine (Clozaril® , FazaClo® ).   Clozapine is a drug used to treat psychosis.  It usually is used for persons...

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