The Frontal Cortex

Johann Hari decides to take Provigil (aka viagra for the brain) and reports back on the results:

I sat down and took one 200mg tablet with a glass of water. Then I pottered about the flat for an hour, listening to music and tidying up, before sitting down on the settee. I picked up a book about quantum physics and super-string theory I have been meaning to read for ages, for a column I’m thinking of writing. It had been hanging over me, daring me to read it. Five hours later, I realised I had hit the last page. I looked up. It was getting dark outside. I was hungry. I hadn’t noticed anything, except the words I was reading, and they came in cool, clear passages; I didn’t stop or stumble once.

Perplexed, I got up, made a sandwich – and I was overcome with the urge to write an article that had been kicking around my subconscious for months. It rushed out of me in a few hours, and it was better than usual. My mood wasn’t any different; I wasn’t high. My heart wasn’t beating any faster. I was just able to glide into a state of concentration – deep, cool, effortless concentration. It was like I had opened a window in my brain and all the stuffy air had seeped out, to be replaced by a calm breeze.

Once that article was finished, I wanted to do more. I wrote another article, all of it springing out of my mind effortlessly. Then I go to dinner with a few friends, and I decide not to tell them, to see if they notice anything. At the end of the dinner, my mate Jess turns to me and says, “You seem very thoughtful tonight.”

If only intelligence were so easy. Before you run out a get an illicit supply of Provigil, let me remind you that the brain is a precisely equilibrated machine. Even drugs that don’t appear to have any negative side-effects – who wouldn’t want a more focused brain? – can actually have deleterious consequences.

In this case, the tradeoff involves creativity. Some of my friends who relied on crushed Ritalin during college used to joke about how the drugs were great for late-night cramming sessions, but that they seemed to suppress any kind of originality. In other words, increased focus came at the expense of the imagination. It makes perfect sense that such a cognitive trade-off would exist. Paying attention to a particular task – like writing an article – requires the brain to ignore all sorts of seemingly unrelated thoughts and stimuli bubbling up from below. (The unconscious brain is full of potential distractions.) However, the same thoughts that can be such annoying interruptions are also the engine of creativity, since they allow us to come up with new connections between previously unrelated ideas. (This might be why schizotypal subjects score higher on tests of creativity. They are less able to ignore those distracting thoughts, which largely arise from the right hemisphere.) Other scientists have looked at the aging brain which, because the prefrontal cortex degrades with time, becomes less able to focus:

“It may be that distractibility is not, in fact, a bad thing,” said Shelley H. Carson, a psychology researcher at Harvard whose work was cited in the book. “It may increase the amount of information available to the conscious mind.”

For example, in studies where subjects are asked to read passages that are interrupted with unexpected words or phrases, adults 60 and older work much more slowly than college students. Although the students plow through the texts at a consistent speed regardless of what the out-of-place words mean, older people slow down even more when the words are related to the topic at hand. That indicates that they are not just stumbling over the extra information, but are taking it in and processing it.

When both groups were later asked questions for which the out-of-place words might be answers, the older adults responded much better than the students.

“For the young people, it’s as if the distraction never happened,” said an author of the review, Lynn Hasher, a professor of psychology at the University of Toronto and a senior scientist at the Rotman Research Institute. “But for older adults, because they’ve retained all this extra data, they’re now suddenly the better problem solvers. They can transfer the information they’ve soaked up from one situation to another.”

Comments

#1 Mr. Gunn
May 20, 2008

Thanks for writing this! Out of the probably over 60 posts now indexed by technorati referencing Johann’s anecdote, you’re the only one to bring up his overly simplistic approach to intelligence. I’ve been making a similar point to yours, saying that speed is a tradeoff for depth. Are we really better off thinking faster but less deep?

Also objectionable to me was that he picked modafinil to write about, but didn’t mention any of the easily available, over the counter, fairly well studied supplements that are also commonly used. Piracetam would be one example and Huperzine A would be another. They’re all discussed in Smart Drugs and Nutrients. The heuristic that if it’s effective, it’s probably dangerous/banned just doesn’t hold in this case, and his experience is way out of line with other accounts. I personally think he could have gotten similar results from a good night’s sleep.

I do think the time has come for people to consider looking into possible enhancements, but as you say, this won’t come without some sort of cost in another area. Potential health effects aren’t the only area of concern.
#2 bob koepp
May 20, 2008

Back in the day, black beauties served a similar “function.” Loads of work was done to exacting standards, but nothing very interesting (i.e., transgressing those standards) emerged.
#3 Jay Neely
May 20, 2008

Hey Jonah,

I’d agree that a trade-off makes sense in light of the context you received the information in, but do you have data to support that theory other than the anecdote of friends using a related but different substance?
#4 Jonah
May 20, 2008

here’s a very limited study:
http://www.informaworld.com/smpp/content~content=a790767848~db=all

But I’d also look at a lot of the research into moments of insight, particularly the work of Mark Jung Beeman. There’s a reason that aha moments often come during relaxed and distracted moments (like the shower)…
#5 Joe Shelby
May 20, 2008

Not “drug” related, but a similar study I once read about (I think it was cited in Tom DeMarco and Timothy Lister’s Peopleware) was about geeks and their listening to music while working. They were given a simple programming task, one easily done in “300 lines” using what we call brute force programming (follow the specified requirements to the letter).

The test was originally designed to see if listening to music while working affected accuracy, with the idea that musical distractions might lead to more bugs in code.

The programmers were allowed to work exactly as they would have worked in real life (this was back before easy internet connections made “cheating” more possible)), so some had headphones full of their favorite music, others worked in silence.

What they found was that both groups (those with music, those without) completed the task with equal accuracy – music didn’t affect that precision.

However, they also discovered that some programmers found a secret in the proposed algorithm they were implementing. With a little cleverness, you could implement the algorithm in only 50 lines instead of the full 300, and be done in half the time. Of those that discovered the shorter implementation, most were from the programming in silence group.
#6 Steve Higgins
May 20, 2008

“Are we really better off thinking faster but less deep?”

I don’t understand why there has to be a trade off. I’m with Jay on this. There being evidence of AHA! moments in some specific form of problem solving without focused attention is only evidence that processing continues below the level of awareness. It is not evidence that you can’t do the same problem solving while being aware or during a focused task, nor is it evidence that creativity is suppressed.

For every story of people reporting that they are less creative while on stimulants I’ve heard just as many stories of people being more creative.

I think this is a lot of fanciful speculation on the part of people trying to find a ‘function’ for mental decline.
#7 Jonah
May 20, 2008

I respectfully disagree, Steve. Look at Jonathan Schooler’s work on verbal overshadowing and insight puzzles. Some aspects of thinking are best left to the unconscious.
#8 Niko
May 20, 2008

I see Hari has linked to this post…
#9 Steve Higgins
May 20, 2008

But is there evidence that increasing attention with drugs decreases processing without awareness?
#10 anonymous
May 20, 2008

I’ve had a little experience with Provigil, and I found that: if one were to also use a little hash, one might find an interesting balance between focus and creativity.

FWIW
#11 Danielle Fong
May 20, 2008

Joe,

If I recall correctly, it was a series of numerical operations which all cancelled out. It could have just been:

def func (x)
x

But instead it went on and on and…
#12 Jamougha
May 20, 2008

You’re speculating though. My experience with modafinil tends say otherwise, too.
#13 Robert 'Groby' Blum
May 20, 2008

It’s an interesting theory, but that’s all it is. It might very well be that Modafinil increases focus without decreasing creativity – there are simply no studies to say one way or another.

If I didn’t value my health, I might be tempted to do a trial

(To anybody who’s considering this: Taking a drag without knowing about long-term effects should be a last resort in dire health situations. Think about it long and hard before you go there)
#14 http
May 21, 2008

So you’re going after provigil…and your argument against it consists of an anecdote about Ritalin, an unrelated drug, and a study about young versus old brains?

I’m all for a good argument against provigil. My guess is there is a catch. But this article doesn’t cut it. There’s no science behind what you’re saying at all yet, at least not that you can find.
#15 KM
May 22, 2008

I recently saw a psychiatric patient about 30, successful in business, who had used these drugs to get through a period of heavy workload and, after a few days with little sleep, became psychotic, believing devils were appearing through the walls, and worse.

This patient may have been predisposed to psychosis, or the effects may have been more to do with sleep deprivation than the drug – who knows? But there was a real problem, and danger both for the patient and others. Further testing needed…
#16 stewart dakers
May 27, 2008

does no-one remember a film with Cliff Robertson called, if my minbd with enhancement recalls correctly, Charlie, where the hero, something of a simpleton. is given such drugs following tests on a mouse, who ends up addressing a seminar of academic celebrati with extraordiunary iknpowledge of a huge range of subjects, beside him the mouse in its cage. Towards the end ofhis olecture/question session, the mouse starts to behave erratically and the final shot of the filmn is Cliff sitting forlornly gawping on a kiddies swing, reduced below where he had started off. Beware.
#17 Therese
May 29, 2008

The film was just called Charly. It was based off the short story/novel, Flowers for Algernon, by Daniel Keyes.
#18 Bwana
June 12, 2008

I wonder if anyone has been treated with Progivil for Obsessive Compulsive Disorder. It makes sense, if you think about it. Having an over-active mind, intrusive thoughts, etc. Would they be controlled or “ignored” with the help of Progivil? I don’t know; it would be worth looking into, though.
#19 Paul
July 3, 2008

I have just started on Provigil a treatment for daytime sleepiness as a result of Obstructive Sleep Apnoea.
I would warn all that Provigil is not without side effects indeed the insert that comes with the drug has a scarily long list.
For my self it has stopped me dropping off but my BP has risen alarmingly and my heart rate frequently hits 122bpm at rest. Other warnings include strange thoughts and other physical effects. I’m on a low dose of 100mg twice a day and to be entirely honest while it keeps me awake it has done nothing for my concentration or memory.
Given the side effects I’m suffering I would be seriously worried about anybody just picking it up and taking 200mg in one hit without medical advice. There are also warnings that prolonged use will cause a level of dependence.

As to the post by KM the Physcosis you describe is classic sleep deprivation. It will happen to anybody deprived of sleep for long enough, that would range from 3 days to 7 depending on the individual. This is why sleep deprivation is used in interogation and torture, in this state people are more prone to suggestion.
#20 Taylor
August 8, 2008

I have a concentration problem but it is not necessarily one of distractability. The problem I have is that as soon as I don’t understand something or in the case of a creative problem solving task, as soon as the next step is not obvious, I become anxious. This makes it unpleasant to continue to concentrate on the problem or to try to understand what I am reading.

This seems to me to be an emotional problem as when I am feeling more self-assured I don’t become nearly as anxious when I don’t immediately understand something and so I am able to stay with it for much longer and to continue to make steady progress. I wonder if anyone has any thoughts on this phenomenon. I’m sure its emotional as opposed to having to do with chemistry or fatigue.
#21 Happy
September 6, 2008

I have been on 300mg provigil for 3 years as I suffer from narcolepsy, The stuff is awesome, I have a near normal life again!! I have a few friends who have come across my prescribed stash and have taken them and as described above, Viagra for the brain, One downside….. I know im a long term user but watch the side effects, take a blood test now and then, Your Liver is quite an important organ.
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#212 Mimari Proje
March 4, 2009

I think this is a lot of fanciful speculation on the part of people trying to find a ‘function’ for mental decline

That’s true completely…
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March 5, 2009

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March 5, 2009

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March 5, 2009

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March 6, 2009

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March 7, 2009

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March 7, 2009

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March 7, 2009

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March 7, 2009

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March 7, 2009

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March 7, 2009

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March 7, 2009

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March 7, 2009

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March 8, 2009

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March 9, 2009

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March 9, 2009

Don’t you folks clean up junk / spam posts around here? Seriously… Starting with post #21. I’d post something substantive here but for the fact that there are approximately 200 utterly worthless SEO posts ahead of me.
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March 9, 2009

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March 9, 2009

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March 9, 2009

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March 10, 2009

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March 10, 2009

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March 12, 2009

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March 12, 2009

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March 12, 2009

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#239 flash oyun
March 12, 2009

yo nunca habia visto a Eugenio Derbez haciendo el papel de malo pero esta pelicula esta muy bonita y si le cae ambos papeles pero lo disfruto mas cuando hace el papel de comedian
#240 flash oyun
March 12, 2009

yo nunca habia visto a Eugenio Derbez haciendo el papel de malo pero esta pelicula esta muy bonita y si le cae ambos papeles pero lo disfruto mas cuando hace el papel de comedian
#241 chat
March 12, 2009

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March 12, 2009

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March 12, 2009

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March 12, 2009

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March 12, 2009

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March 13, 2009

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March 13, 2009

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March 13, 2009

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April 13, 2009

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April 13, 2009

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April 19, 2009

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April 21, 2009

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April 23, 2009

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April 23, 2009

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April 24, 2009

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April 27, 2009

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April 27, 2009

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April 28, 2009

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April 28, 2009

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#261 Türkçe Forum
April 28, 2009

I think this is a lot of fanciful speculation on the part of people trying to find a ‘function’ for mental decline
That’s true completely…
#262 Rob T.
April 29, 2009

Your objections seem to ignore aspects of Johan’s narrative, such as his subjective sensations of feeling contemplative and unhurried. Such mental states clearly correlate with the creative mindset, no?
#263 tatil
May 1, 2009

If the clients were always right, they wouldn’t need me in the first place.
#264 Chat Odaları
May 3, 2009

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May 3, 2009

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May 4, 2009

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May 7, 2009

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May 7, 2009

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May 8, 2009

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May 12, 2009

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May 14, 2009

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#272 plastik
May 14, 2009

I guess we can safely assume those are the production headlamps. Dang Ed, I thought the coupe was nice, but the convertible is sexy… even with the top up!
#273 ajans
May 15, 2009

Thanks yOu
#274 motosiklet
May 15, 2009

Verry Good Thanks You
#275 araba
May 15, 2009

I guess we can safely assume those are the production headlamps. Dang Ed, I thought the coupe was nice, but the convertible is sexy… even with the top up! Verry Good Site Thanks Youuuuu
#276 sohbet
May 18, 2009

I guess we can safely assume those are the production headlamps. Dang Ed, I thought the coupe was nice, but the convertible is sexy… even with the top up!
#277 sohbet odaları
May 18, 2009

I recently saw a program on squid coming more to the surface and spreading northwards along the South and North American coasts. Could it be that the squid are moving up from the lower depths because the sharks just aren’t there any more in the upper waters?
#278 filmizle film izle sinema
May 19, 2009

nice man thanx fazla bisey anlamadım ama yinede iyi
#279 بنت الخليج
May 21, 2009

Thank you for Kln
#280 mario oyunları
May 22, 2009

I guess we can safely assume those are the production headlamps.
#281 yasar
May 23, 2009

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#282 Msn 9.5 İndir
May 25, 2009

Thank You
#283 Msn 9.5 İndir
May 25, 2009

Thank You Well
#284 Kültür Turları
May 25, 2009

about our work here, this kind of competitions are regulated. I do not find much success, but many interesting things can occur
#285 Okey
June 3, 2009

Thank you well
#286 mIRCINDIR
June 4, 2009

thanksyou
#287 muhabbet
June 4, 2009

thank you.
#288 video izle
June 5, 2009

“Are we really better off thinking faster but less deep?”

I don’t understand why there has to be a trade off. I’m with Jay on this. There being evidence of AHA! moments in some specific form of problem solving without focused attention is only evidence that processing continues below the level of awareness. It is not evidence that you can’t do the same problem solving while being aware or during a focused task, nor is it evidence that creativity is suppressed.

For every story of people reporting that they are less creative while on stimulants I’ve heard just as many stories of people being more creative.

I think this is a lot of fanciful speculation on the part of people trying to find a ‘function’ for mental decline.
#289 paylasonline
June 7, 2009

thanks a lot
#290 Zemin Kaplama
June 7, 2009

Thak You
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June 9, 2009

Back in the day, black beauties served a similar “function.” Loads of work was done to exacting standards, but nothing very interesting (i.e., transgressing those standards) emerged.
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June 11, 2009

The thing is, the Irish users are, under this ruling, guilty until proven innocent, and the kicker is that they don’t even have the chance to prove their innocence. The procedure that’s been put in place doesn’t even allow them to try and defend themselves. As long as the Man *says* their downloading, then they are, there’s no attempt to substantiate the claims, no examination of evidence, hell they don’t even have to provide evidence.
So if the user’s got a Wifi setup at home with no encryption (not a crime, there’s valid reasons to have such a setup) or if their wifi uses weak encryption (again, not a crime), heck even WPA been’s cracked now. If someone piggy backs onto their network then they are screwed.
I’m pretty damned sure that EU law, which overrules Irish law in cases like this, has got something to say about this
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June 12, 2009

“For the young people, it’s as if the distraction never happened,” said an author of the review, Lynn Hasher” I do not agree with that i mean does not have to be young ppl always.
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“For the young people, it’s as if the distraction never happened,” said an author of the review, Lynn Hasher” I do not agree with that i mean does not have to be young ppl always.
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For the young people, it’s as if the distraction never happened,” said an author of the review, Lynn Hasher” I do not agree with that i mean does not have to be young ppl always.
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For the young people, it’s as if the distraction never happened,” said an author of the review, Lynn Hasher” I do not agree with that i mean does not have to be young ppl always.
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So if the user’s got a Wifi setup at home with no encryption (not a crime, there’s valid reasons to have such a setup) or if their wifi uses weak encryption (again, not a crime), heck even WPA been’s cracked now. If someone piggy backs onto their network then they are screwed
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All their peer review publications on subject are freely available to download from here. The algorithms for developing such as system are found in t
#317 sohbet
July 30, 2009

Your objections seem to ignore aspects of Johan’s narrative, such as his subjective sensations of feeling contemplative and unhurried. Such mental states clearly correlate with the creative mindset, no?
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RFC 741 describes the Network Voice Protocol and mentions that it was first implemented December 1973, over twenty years prior to the filing of Weinberger et al.’s patents.
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Your objections seem to ignore aspects of Johan’s narrative, such as his subjective sensations of feeling contemplative and unhurried. Such mental states clearly correlate with the creative mindset, no?
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August 7, 2009

I guess we can safely assume those are the production headlamps.
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August 7, 2009

I guess we can safely assume those are the production headlamps. Dang Ed, I thought the coupe was nice, but the convertible is sexy… even with the top up!
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RFC 741 describes the Network Voice Protocol and mentions that it was first implemented December 1973,
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September 1, 2009

t’s an interesting theory, but that’s all it is. It might very well be that Modafinil increases focus without decreasing creativity – there are simply no studies to say one way or another.

If I didn’t value my health, I might be tempted to do a trial

(To anybody who’s considering this: Taking a drag without knowing about long-term effects should be a last resort in dire health situations. Think about it long and hard before you go there)
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September 2, 2009

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September 4, 2009

increases focus without decreasing creativity – there are simply no studies to say one way or another.

If I didn’t value my health
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September 9, 2009

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Your objections seem to ignore aspects of Johan’s narrative, such as his subjective sensations of feeling contemplative and unhurried. Such mental states clearly correlate with the creative mindset, no?
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increases focus without decreasing creativity – there are simply no studies to say one way or another.
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September 19, 2009

ctually, they can. That’s what happens in nuclear reactions (a nucleus sheds or accepts a particle in order to become more stable.) Not saying this happens in these plasma incinerators, though – don’t know anything about that.
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September 19, 2009

You know, whenever I hear of an aggressive price drop, it immediately make me think a new product is about to be launched and the manufacturer is trying to clear out inventory beforehand. (i.e. Apple giving away free iPods with a new computer purchase in the Fall.)

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September 28, 2009

Provigil is a stimulant and I imagine it has similar side-effects to any other stimulant out there. Exercise, proper sleep and a diet(excluding stimulants you crackheads) is the best thing for mental clarity.
#357 Heike
September 28, 2009

An interesting theory, but that’s all it is.

Regards

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October 2, 2009

Provigil is a stimulant and I imagine it has similar side-effects to any other stimulant out there. Exercise, proper sleep and a diet(excluding stimulants you crackheads) is the best thing for mental clarity.
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October 2, 2009

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October 10, 2009

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Clearly the “science” here is not biology.

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November 2, 2009

Provigil is not Ritalin. The only connection between the two mentioned in your article is this concept of “focus”. This is not a constant pervasive enough to allay the properties of one to the other. The two have massively different effects and chemistries. If your advise is founded on some reason, include it in the article. Otherwise you’re just peddling attractive crisis to helpless paranoiacs. This is not a responsible critique, it’s an overgeneralized paternalistic foreboding.
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November 9, 2009

Provigil is not Ritalin. The only connection between the two mentioned in your article is this concept of “focus”. This is not a constant pervasive enough to allay the properties of one to the other. The two have massively different effects and chemistries. If your advise is founded on some reason, include it in the article. Otherwise you’re just peddling attractive crisis to helpless paranoiacs. This is not a responsible critique, it’s an overgeneralized paternalistic foreboding.
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Provigil is not Ritalin. The only connection between the two mentioned in your article is this concept of “focus”. This is not a constant pervasive enough to allay the properties of one to the other. The two have massively different effects and chemistries. If your advise is founded on some reason, include it in the article. Otherwise you’re just peddling attractive crisis to helpless paranoiacs. This is not a responsible critique, it’s an overgeneralized paternalistic foreboding.
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Provigil is not Ritalin. The only connection between the two mentioned in your article is this concept of “focus”. This is not a constant pervasive enough to allay the properties of one to the other.
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Interesting post ToM. You said, ?it uses and alters the shot material of Brando without his consent or creative consultation.? That might be somewhat difficult due to Brando?s being dead
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November 30, 2009

Provigil is a stimulant and I imagine it has similar side-effects to any other stimulant out there. Exercise, proper sleep and a diet(excluding stimulants you crackheads) is the best thing for mental clarity.
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“In this case, the tradeoff involves creativity. Some of my friends who relied on crushed Ritalin during college used to joke about how the drugs were great for late-night cramming sessions, but that they seemed to suppress any kind of originality.”
1. Drug X improves some aspects of thought processes
2. Drug Y was also known to improve some aspects of thought processes
3a. It seems to some people that drug Y decreased originality
3b. I believe that such a cognitive trade-off would exist
4. Therefore X also decreases originality (??)

Aaaaarrrgggghhhh!!!!
1. If the trade-off does exist normally, who knows, maybe Modafinil, or something else, works around it. To the best of my lay knowledge, the science of workings of brains and minds is not an exact science.
2. Who says you have to take it all the time? You wear thinner clothes in summer and thicker clothes in winter, don’t you? Is there a such a thing as best all-weather clothing? (I don’t care if there is some sort of “best clothing”. I was just trying to point out fallacious reasoning)

Another thing: Though I have seen enough articles linking schizophrenia (the author wrongly calls them “schizotypal subject”, quite laymanish of him) and creativity, it is wrong to believe that people without this disorder cannot be just as creative, or more creative than people with schizophreina.
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Provigil is not Ritalin. The only connection between the two mentioned in your article is this concept of “focus”. This is not a constant pervasive enough to allay the properties of one to the other. The two have massively different effects and chemistries. If your advise is founded on some reason, include it in the article. Otherwise you’re just peddling attractive crisis to helpless paranoiacs. This is not a responsible critique, it’s an overgeneralized paternalistic foreboding.
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I’ve had a little experience with Provigil, and I found that: if one were to also use a little hash, one might find an interesting balance between focus and creativity.
uydu
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March 18, 2010

d to control. “Only animation seems to be able so far to do justice to the world we are supposed to be living in… everything on Earth seems small and stunted in its magnificence and our atmosphere feels harsh after glimpsing into the world of the Na’vi.” In this new myth John Wayne and the “Marlborough” man sufferers a crushing defeat and the Indians prevail. T
#481 siirt
March 22, 2010

Who says you have to take it all the time? You wear thinner clothes in summer and thicker clothes in winter, don’t you? Is there a such a thing as best all-weather clothing? (I don’t care if there is some sort of “best clothing”. I was just trying to point out fallacious reasoning)
Thank you!
#482 Ozle
March 24, 2010

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#483 KaRa
March 26, 2010

Never saw something like that
#484 araba oyunları
March 26, 2010

Just as I thought… freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.
#485 Nagelstudio
April 3, 2010

Great stuff guys! I really don’t know how much time it takes for your guys to compile such a list of excellent resources but it takes a lot of time for me to digest it all! Keep up the good work! Thank you!
#486 Morbus Meniere
April 3, 2010

Interesting article… Wasn’t aware of all the background information.
#487 Sohbet odalari
April 5, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want
#488 video izle
April 9, 2010

I’m to guessing the only way to do this in Js would be to use the onresize event, and then using the resize To method to attempt to keep the window at the size you want
#489 Bursa Haber
April 13, 2010

If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone
#490 gaziantep evden eve taşımacılık
April 14, 2010

Just as I thought… freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.
#491 güvenlik kamerası
April 15, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want
#492 seo
April 15, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want
#493 jaluzi
April 16, 2010

The thing is, the Irish users are, under this ruling, guilty until proven innocent, and the kicker is that they don’t even have the chance to prove their innocence. The procedure that’s been put in place doesn’t even allow them to try and defend themselves. As long as the Man *says* their downloading, then they are, there’s no attempt to substantiate the claims, no examination of evidence, hell they don’t even have to provide evidence.
#494 Kemal
April 19, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want http://www.gazikentmedikal.com
#495 Kameralı Sohbet
April 25, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want
#496 Almanya Sohbet
April 25, 2010

Just as I thought… freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.
#497 Çet
April 25, 2010

his is not a constant pervasive enough to allay the properties of one to the other. The two have massively different effects and chemistries. If your advise is founded on some reason, include it in the article. Otherwise you’re just peddling attractive crisis to helpless paranoiacs.
#498 sexy ladies
April 26, 2010

The rich get richer and the poor get poorer.
#499 oyun oyna
April 27, 2010

isney and spend their money of some Chinese Disney crap. Leave the rest of us alone
#500 Hayata Dair Herşey
April 28, 2010

The rich get richer and the poor get poorer.
#501 sikiş izle
April 28, 2010

Just as I thought… freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.
#502 Hayata Dair Herşey
April 29, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want
#503 spor
May 1, 2010

Interesting article… Wasn’t aware of all the background information.
#504 SesliSohbet
May 1, 2010

The rich get richer and the poor get poorer. vayss
#505 asik siteleri
May 3, 2010

CAER Director Rodney Andrews and researchers Tom Robl, Mark Crocker, Jim Neathery and Burt Davis met with the journalists in their separate laboratories, providing project descriptions and progress evaluations and answering questions during the morning-long tour.
güzel sözler
Aşk Siteleri
Sevgi Siteleri
aşk şiirleri

Andrews supplied a brief overview of energy issues raised by the group. Of the visit, he says, “These visits provide opportunities to explain technical issues to a broader public. These reporters write about energy issues in their home countries and throughout the world, and we appreciate this chance to educate them on what the state is doing to advance all types of energy research.”

The journalists then were taken directly to labs where research is being conducted and spoke with the researchers about their projects.
aşk sözleri
Aşk Mesajlari
Aşk

“The tour was better than I thought it would be. Too often, we get taken to classrooms and given lectures. This time, we were taken straight to the laboratories where we could interview the scientists and take pictures. It’s best to see the technology than just being briefed,” said Mit Obe, a journalist with Japan’s JiJi.
#506 Tekne
May 21, 2010

If you liked this article, feel free to re-tweet it to let others know. Thanks, we appreciate it
#507 Orjin Krem
May 25, 2010

The rich get richer and the poor get poorer.
#508 Abaki Samsun
May 27, 2010

Its right; the rich get richer and the poor get poorer;

This are the rules.
#509 Muhabbet
May 31, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want
#510 aöf
June 4, 2010

If you liked this article, feel free to re-tweet it to let others know. Thanks, we appreciate it
#511 sohbet odaları
June 9, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want
#512 sikiş
June 10, 2010

Just as I thought… freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.
#513 takı
June 16, 2010

Just as I thought… freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.
#514 sohbet odaları
July 2, 2010

If you liked this article, feel free to re-tweet it to let others know. Thanks, we appreciate it
#515 dizi izle
July 3, 2010

Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.
#516 mujeres rusas
July 7, 2010

I do think the time has come for people to consider looking into possible enhancements, but as you say, this won’t come without some sort of cost in another area. Potential health effects aren’t the only area of concern.
#517 oyun oyna
July 10, 2010

If you liked this article, feel free to re-tweet it to let others know. Thanks, we appreciate it
#518 film izle
July 14, 2010

Just as I thought… freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.
#519 Ambalaj
July 18, 2010

The rich get richer and the poor get poorer. very good
#520 Gubatron
July 18, 2010

Given the original article has no comments, I’ll ask here.

Where the hell can you buy it and try for yourself, online without getting scammed?
#521 takı
July 19, 2010

the rich get richer and the poor get poorer. very good
#522 Görsel Sanatlar
July 21, 2010

Görsel Sanatlar Dergisi’ni mutlaka okuyun. Dergi bana ait değil ama bir tanıdığıma ait. Hep destek tam destek!
#523 travesti
July 24, 2010

Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.
#524 guzelsoz
July 24, 2010

Yeah man I dont have able too. And I watch some blogs this show. Thansk anyway. Bad Tony Rulzzzz
#525 Anadolu Cam Balkon
July 29, 2010

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#526 osmaniye emlak
August 2, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want thanks admin good blog
#527 konya chat
August 2, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want thank you moderator
#528 izmir chat
August 2, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want thanks admin perfect blog
#529 seslisohbet
August 5, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want thanks admin perfect blog
#530 bestbuy
August 6, 2010

If you liked this article, feel free to re-tweet it to let others know. Thanks, we appreciate it
#531 pansiyon
August 9, 2010

The rich get richer and the poor get poorer. vayss
#532 Alejandro Roman
August 9, 2010

The obvious class of this article enthralls me in innumerable aspects that you, the author of this writing might scarcely understand. May this forever keep going. Best Wishes, Alejandro Roman
#533 orjin krem
August 10, 2010

As long as the Man *says* their downloading, then they are, there’s no attempt to substantiate the claims, no examination of evidence, hell they don’t even have to provide evidence.
#534 koxp
August 10, 2010

the rich get richer and the poor get poorer. very good
#535 sohbet
August 13, 2010

I prefer schokakola. Its the most effective chocolate in the World. One piece has more coffein than a mug coffee.
#536 Derrekito
August 14, 2010

This piece is too alarmist drowning in speculation. If you stick to what is scientifically known (and cite it as such) I would be more inclined to accept your premise. Additionally, what does the aging brain have to do with your experience using Provigil (sorry it simply thew me off)?
#537 Derrekito
August 15, 2010

Sorry, I forgot to mention that my response was meant to be toward Hari.
#538 error fix
August 16, 2010

I’d agree that a trade-off makes sense in light of the context you received the information in, but do you have data to support that theory other than the anecdote of friends using a related but different substance?
#539 caner
August 18, 2010

the rich get richer and the poor get poorer. very good
#540 Electronic Cigarette
August 19, 2010

Once that article was finished, I wanted to do more. I wrote another article, all of it springing out of my mind effortlessly. Then I go to dinner with a few friends, and I decide not to tell them, to see if they notice anything. At the end of the dinner, my mate Jess turns to me and says, “You seem very thoughtful tonight.” ;D
#541 sağlık
August 21, 2010

Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want thanks admin good blog
#542 buz
August 23, 2010

possibility of sharing and social solidarity at a level just fine thank you
#543 buz
August 23, 2010

possibility of sharing and social solidarity at a level just fine
#544 siyah peynir
August 24, 2010

I wonder if anyone has been treated with Progivil for Obsessive Compulsive Disorder. It makes sense, if you think about it. Having an over-active mind, intrusive thoughts, etc. Would they be controlled or “ignored” with the help of Progivil? I don’t know; it would be worth looking into, though.
#545 Şarkı Sözü
August 25, 2010

I’d agree that a trade-off makes sense in light of the context you received the information in, but do you have data to support that theory other than the anecdote of friends using a related but different substance?
#546 seolinkvine
August 27, 2010

I’ve gotta say it is pretty evident you know whats up.This is something I’ll be submitting to Reddit.I’m thinking this is the best post I’ve read on your blog yet.I’ll be back for sure, excellent stuff.
#547 myarticlenetwork
August 27, 2010

Great post, this is the quality I like to see.I’m going to be tweeting this to my followers as I think it’s pretty important.I’d recommend writing additional posts like this one as it’s one of your best.I’ll check back often, I’m glad I came across your site.
#548 hi5
August 31, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want thank you hi5 sosyal ağ
#549 suskun
September 5, 2010

Although personally I think Petraus is nearly irrelevant I think the war is really just ours to lose. By that I mean historically the sacrifices the WOT is demanding so far of US is sustainable for decades if needed.
#550 sağlık personeli
September 13, 2010

thanks babacan admin nice sağlık good.
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September 16, 2010

thankyou the rich get richer and the poor get poorer. very good

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#552 New Fx15
September 18, 2010

thankyou the rich get richer and the poor get poorer. very good
#553 çorum haber
September 22, 2010

The rich get richer and the poor get poorer
#554 Poster
September 24, 2010

The rich get richer and the poor get poorer
^ what he said!
#555 ilahi
September 27, 2010

thankyou the rich get richer and the poor get poorer. very good
#556 photoshopsitesi
September 28, 2010

Sorry, I forgot to mention that my response was meant to be toward Hari.
#557 kabin
September 28, 2010

Then I go to dinner with a few friends, and I decide not to tell them, to see if they notice anything. At the end of the dinner, my mate Jess turns to me and says, “You seem very thoughtful tonight
#558 mirc
October 2, 2010

One of the very best discussions. Each of the guests was both knowledgeable and cranky, and Dvorak let them speak.
#559 siemens servisi
October 4, 2010

I tire of these idiots easily.
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October 6, 2010

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#561 Andrei Gravura
October 11, 2010

Great design first thing… Second thing the prespective at which you see the sport is quite neutral quite in my words wikipedia style. This is a welcome change from people who are either racist or support a particular agenda.!
#562 çet
October 11, 2010

thank you
#563 Kfz Versicherung
October 14, 2010

Back in the day, black beauties served a similar “function.” Loads of work was done to exacting standards, but nothing very interesting (i.e., transgressing those standards) emerged.
#564 sağlık
October 18, 2010

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October 21, 2010

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October 26, 2010

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#567 ambalaj
October 29, 2010

Is not nothin much to say about this page. I think a very successful and useful. thank you
#568 Karry Ebadi
October 29, 2010

After dark all cats are leopards
#569 Player Profiles
October 30, 2010

You you should change the page subject title The Hidden Cost of Smart Drugs : The Frontal Cortex to more suited for your subject you write. I liked the the writing however.
#570 bayan escort
October 31, 2010

Great design first thing… Second thing the prespective at which you see the sport is quite neutral quite in my words wikipedia style. This is a welcome change from people who are either racist or support a particular
#571 düzce haber
November 1, 2010

the rich get richer and the poor get poorer. very good
#572 çocuk oyunlar?,
November 3, 2010

Harika oyunlar
#573 mario oyun,
November 3, 2010

boyle oturdgunuz yerden abuk subuk konusurken Doguda nobet tutan kardeslerimizi de dusunun,
#574 oyun,
November 3, 2010

elinize emeginize saglik admin arkadas
#575 araba oyun,
November 4, 2010

supper oyun, bunu bilgisayara indirmenin yolu yokmu?
#576 güzel oyunlar,
November 4, 2010

supper oyun, bunu bilgisayara indirmenin yolu yokmu?
#577 Bedava oyun oyna,oyunlar,
November 4, 2010

bu siteyi seviyorum
#578 Sohbet
November 4, 2010

so much fortunate is from his tender and kind wife from many aspects. The reason why she looks old is because of him. He do not want his wife go back. He wants her live with him together. He don’t want her suffer so much miserable life as before
#579 oyna,
November 5, 2010

cok guzel film herkeslere tavsiye ederim
#580 indir izle
November 14, 2010

çok güzel filmlerin adresi teşeküür
#581 çuval
November 16, 2010

1995 Yılında Çuval imalatına başlayan firmamız kısa süre içersinde sektörün lider firmalarından biri haline gelmiştir.Öncelikle Polipropilen çuval ile başlamış olup aynı yıl içersinde her renk, ebat ve gramaja uygun P.P Çuval, Kanaviçe Çuval, Big Bag Çuval ve Şeffaf Çuval üretimine geçmiştir.
#582 Mauricio Cassio
November 16, 2010

Very usefull post would it be OK if i mention this on my blog? Thanks
#583 hicrettaylan
November 17, 2010

The rich get richer and the poor get poorer
#584 Tommye Highfield
November 23, 2010

for the part he’s played in the ethanol boon doggle? Plus think of all the time, effort, and money wasted; not to mention what other alternatives could have been researched or implemented? Could this be one the first win-able Climate Change lawsuits?
#585 Facial Mole Removal
November 24, 2010

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#586 Earl Morales
November 29, 2010

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#587 cam balkon
December 7, 2010

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#588 artdecor
December 8, 2010

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#589 ambalaj
December 9, 2010

ambalaj ürünleri burada
#590 proje haberleri
December 11, 2010

the rich get richer and the poor get poorer. very good
#591 Facebook Video Izle
December 12, 2010

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#592 escortbayanankara
December 12, 2010

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#593 Moteriski kvepalai
December 12, 2010

Hi. First of all – nice blog! Secondly this information was also good and interesting to read, but I don’t think everything you have said is real truth. I will need to google about few things you have mentioned in your artcile to make sure. But anyway thanks for trying and good luck on writing other articles. P.S sorry for bad English, I aren’t English native speaker.
#594 Vyriski kvepalai
December 13, 2010

Greetings. First of all – wonderful blog! Secondly this information was also good and interesting to read, but I don’t think everything you have said is completely true. I will need to google about few things you have mentioned in your artcile to make sure. But anyway thanks for taking your time to write intresting artciles and good luck on writing other articles. P.S sorry for bad English, I aren’t English native speaker.
#595 fesbuk
December 13, 2010

I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want thank you
#596 Dentist in Marana
December 15, 2010

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#597 escortbayanankara
December 16, 2010

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#598 Tasia Kietzman
December 16, 2010

Grand article peut I à traduire Français pour notre emplacements lecteurs ? Si c’est CORRECT de quel type reconnaissance vous préféreriez ?
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December 19, 2010

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January 4, 2011

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#601 escort bayan ist
January 8, 2011

Most lifelong democrats I know believe the Pelosi congress is populated by imbeciles. Ogabe/Pelosi/Reid have really pissed in the Holy Water when it comes to traditional democrats.
#602 mase plastice
January 8, 2011

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#603 seslikameralisohbet
January 8, 2011

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#604 Linda B.
January 8, 2011

I actually cogitated this was visiting be interesting, good thing I had a picture as back-up. (back-up the whole thing , reasonable advice).
#605 Ann Mitchell
January 12, 2011

I’ve learned so much on the internet in the past years. The most of my know-how I attribute to reading through excellent blogs like yours. Thank you!
#606 Kıbrıs Haber
January 14, 2011

You’re speculating though. My experience with modafinil tends say otherwise, too.
#607 Batak oyna
January 15, 2011

possibility of sharing and social solidarity at a level just fine thank you
#608 Bertrum Keels
January 17, 2011

I believed Scarlett Johansson looked like she was trying out for the Rocky Horror Picture Show. Magenta referred to as and would like her hairstyle back. All that was missing were the white streaks
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January 22, 2011

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#610 Cam Balkon
January 24, 2011

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#611 fesbuk giriş
January 25, 2011

I have a concentration problem but it is not necessarily one of distractability. The problem I have is that as soon as I don’t understand something or in the case of a creative problem solving task, as soon as the next step is not obvious, I become anxious. This makes it unpleasant to continue to concentrate on the problem or to try to understand what I am reading.
#612 kadınlar kulübü
February 5, 2011

Most lifelong democrats I know believe the Pelosi congress is populated by imbeciles. Ogabe/Pelosi/Reid have really pissed in the Holy Water when it comes to traditional democrats.
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February 7, 2011

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February 7, 2011

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February 8, 2011

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February 20, 2011

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February 25, 2011

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February 28, 2011

ctually, they can. That’s what happens in nuclear reactions (a nucleus sheds or accepts a particle in order to become more stable.) Not say. this happens in these plasma incinerators, though – don’t know anything about that
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April 14, 2011

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April 14, 2011

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April 14, 2011

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April 14, 2011

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April 22, 2011

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April 23, 2011

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April 23, 2011

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April 25, 2011

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April 25, 2011

That’s what happens in nuclear reactions (a nucleus sheds or accepts a particle in order to become more stable.) Not say. this happens in these plasma incinerators, though – don’t know anything about that
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May 7, 2011

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May 9, 2011

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May 9, 2011

Not say. this happens in these plasma incinerators, though – don’t know anything about that
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May 9, 2011

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May 9, 2011

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May 11, 2011

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June 7, 2011

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July 11, 2011

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July 12, 2011

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August 8, 2011

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August 12, 2011

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August 21, 2011

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August 23, 2011

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August 24, 2011

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October 7, 2011

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October 9, 2011

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October 9, 2011

arkozy’s rejection of Turkey’s EU membership,” the title of the news site that uses the words of Sarkozy, has included the following: “Turkey can be a bridge between Europe and Asia, but not the place of Turkey in the EU.
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October 20, 2011

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October 29, 2011

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November 1, 2011

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