The Frontal Cortex

The Hidden Cost of Smart Drugs

Johann Hari decides to take Provigil (aka viagra for the brain) and reports back on the results:

I sat down and took one 200mg tablet with a glass of water. Then I pottered about the flat for an hour, listening to music and tidying up, before sitting down on the settee. I picked up a book about quantum physics and super-string theory I have been meaning to read for ages, for a column I’m thinking of writing. It had been hanging over me, daring me to read it. Five hours later, I realised I had hit the last page. I looked up. It was getting dark outside. I was hungry. I hadn’t noticed anything, except the words I was reading, and they came in cool, clear passages; I didn’t stop or stumble once.

Perplexed, I got up, made a sandwich – and I was overcome with the urge to write an article that had been kicking around my subconscious for months. It rushed out of me in a few hours, and it was better than usual. My mood wasn’t any different; I wasn’t high. My heart wasn’t beating any faster. I was just able to glide into a state of concentration – deep, cool, effortless concentration. It was like I had opened a window in my brain and all the stuffy air had seeped out, to be replaced by a calm breeze.

Once that article was finished, I wanted to do more. I wrote another article, all of it springing out of my mind effortlessly. Then I go to dinner with a few friends, and I decide not to tell them, to see if they notice anything. At the end of the dinner, my mate Jess turns to me and says, “You seem very thoughtful tonight.”

If only intelligence were so easy. Before you run out a get an illicit supply of Provigil, let me remind you that the brain is a precisely equilibrated machine. Even drugs that don’t appear to have any negative side-effects – who wouldn’t want a more focused brain? – can actually have deleterious consequences.

In this case, the tradeoff involves creativity. Some of my friends who relied on crushed Ritalin during college used to joke about how the drugs were great for late-night cramming sessions, but that they seemed to suppress any kind of originality. In other words, increased focus came at the expense of the imagination. It makes perfect sense that such a cognitive trade-off would exist. Paying attention to a particular task – like writing an article – requires the brain to ignore all sorts of seemingly unrelated thoughts and stimuli bubbling up from below. (The unconscious brain is full of potential distractions.) However, the same thoughts that can be such annoying interruptions are also the engine of creativity, since they allow us to come up with new connections between previously unrelated ideas. (This might be why schizotypal subjects score higher on tests of creativity. They are less able to ignore those distracting thoughts, which largely arise from the right hemisphere.) Other scientists have looked at the aging brain which, because the prefrontal cortex degrades with time, becomes less able to focus:

“It may be that distractibility is not, in fact, a bad thing,” said Shelley H. Carson, a psychology researcher at Harvard whose work was cited in the book. “It may increase the amount of information available to the conscious mind.”

For example, in studies where subjects are asked to read passages that are interrupted with unexpected words or phrases, adults 60 and older work much more slowly than college students. Although the students plow through the texts at a consistent speed regardless of what the out-of-place words mean, older people slow down even more when the words are related to the topic at hand. That indicates that they are not just stumbling over the extra information, but are taking it in and processing it.

When both groups were later asked questions for which the out-of-place words might be answers, the older adults responded much better than the students.

“For the young people, it’s as if the distraction never happened,” said an author of the review, Lynn Hasher, a professor of psychology at the University of Toronto and a senior scientist at the Rotman Research Institute. “But for older adults, because they’ve retained all this extra data, they’re now suddenly the better problem solvers. They can transfer the information they’ve soaked up from one situation to another.”

Comments

  1. #1 Mr. Gunn
    May 20, 2008

    Thanks for writing this! Out of the probably over 60 posts now indexed by technorati referencing Johann’s anecdote, you’re the only one to bring up his overly simplistic approach to intelligence. I’ve been making a similar point to yours, saying that speed is a tradeoff for depth. Are we really better off thinking faster but less deep?

    Also objectionable to me was that he picked modafinil to write about, but didn’t mention any of the easily available, over the counter, fairly well studied supplements that are also commonly used. Piracetam would be one example and Huperzine A would be another. They’re all discussed in Smart Drugs and Nutrients. The heuristic that if it’s effective, it’s probably dangerous/banned just doesn’t hold in this case, and his experience is way out of line with other accounts. I personally think he could have gotten similar results from a good night’s sleep.

    I do think the time has come for people to consider looking into possible enhancements, but as you say, this won’t come without some sort of cost in another area. Potential health effects aren’t the only area of concern.

  2. #2 bob koepp
    May 20, 2008

    Back in the day, black beauties served a similar “function.” Loads of work was done to exacting standards, but nothing very interesting (i.e., transgressing those standards) emerged.

  3. #3 Jay Neely
    May 20, 2008

    Hey Jonah,

    I’d agree that a trade-off makes sense in light of the context you received the information in, but do you have data to support that theory other than the anecdote of friends using a related but different substance?

  4. #4 Jonah
    May 20, 2008

    here’s a very limited study:
    http://www.informaworld.com/smpp/content~content=a790767848~db=all

    But I’d also look at a lot of the research into moments of insight, particularly the work of Mark Jung Beeman. There’s a reason that aha moments often come during relaxed and distracted moments (like the shower)…

  5. #5 Joe Shelby
    May 20, 2008

    Not “drug” related, but a similar study I once read about (I think it was cited in Tom DeMarco and Timothy Lister’s Peopleware) was about geeks and their listening to music while working. They were given a simple programming task, one easily done in “300 lines” using what we call brute force programming (follow the specified requirements to the letter).

    The test was originally designed to see if listening to music while working affected accuracy, with the idea that musical distractions might lead to more bugs in code.

    The programmers were allowed to work exactly as they would have worked in real life (this was back before easy internet connections made “cheating” more possible)), so some had headphones full of their favorite music, others worked in silence.

    What they found was that both groups (those with music, those without) completed the task with equal accuracy – music didn’t affect that precision.

    However, they also discovered that some programmers found a secret in the proposed algorithm they were implementing. With a little cleverness, you could implement the algorithm in only 50 lines instead of the full 300, and be done in half the time. Of those that discovered the shorter implementation, most were from the programming in silence group.

  6. #6 Steve Higgins
    May 20, 2008

    “Are we really better off thinking faster but less deep?”

    I don’t understand why there has to be a trade off. I’m with Jay on this. There being evidence of AHA! moments in some specific form of problem solving without focused attention is only evidence that processing continues below the level of awareness. It is not evidence that you can’t do the same problem solving while being aware or during a focused task, nor is it evidence that creativity is suppressed.

    For every story of people reporting that they are less creative while on stimulants I’ve heard just as many stories of people being more creative.

    I think this is a lot of fanciful speculation on the part of people trying to find a ‘function’ for mental decline.

  7. #7 Jonah
    May 20, 2008

    I respectfully disagree, Steve. Look at Jonathan Schooler’s work on verbal overshadowing and insight puzzles. Some aspects of thinking are best left to the unconscious.

  8. #8 Niko
    May 20, 2008

    I see Hari has linked to this post…

  9. #9 Steve Higgins
    May 20, 2008

    But is there evidence that increasing attention with drugs decreases processing without awareness?

  10. #10 anonymous
    May 20, 2008

    I’ve had a little experience with Provigil, and I found that: if one were to also use a little hash, one might find an interesting balance between focus and creativity.

    FWIW

  11. #11 Danielle Fong
    May 20, 2008

    Joe,

    If I recall correctly, it was a series of numerical operations which all cancelled out. It could have just been:

    def func (x)
    x

    But instead it went on and on and…

  12. #12 Jamougha
    May 20, 2008

    You’re speculating though. My experience with modafinil tends say otherwise, too.

  13. #13 Robert 'Groby' Blum
    May 20, 2008

    It’s an interesting theory, but that’s all it is. It might very well be that Modafinil increases focus without decreasing creativity – there are simply no studies to say one way or another.

    If I didn’t value my health, I might be tempted to do a trial ;)

    (To anybody who’s considering this: Taking a drag without knowing about long-term effects should be a last resort in dire health situations. Think about it long and hard before you go there)

  14. #14 http
    May 21, 2008

    So you’re going after provigil…and your argument against it consists of an anecdote about Ritalin, an unrelated drug, and a study about young versus old brains?

    I’m all for a good argument against provigil. My guess is there is a catch. But this article doesn’t cut it. There’s no science behind what you’re saying at all yet, at least not that you can find.

  15. #15 KM
    May 22, 2008

    I recently saw a psychiatric patient about 30, successful in business, who had used these drugs to get through a period of heavy workload and, after a few days with little sleep, became psychotic, believing devils were appearing through the walls, and worse.

    This patient may have been predisposed to psychosis, or the effects may have been more to do with sleep deprivation than the drug – who knows? But there was a real problem, and danger both for the patient and others. Further testing needed…

  16. #16 stewart dakers
    May 27, 2008

    does no-one remember a film with Cliff Robertson called, if my minbd with enhancement recalls correctly, Charlie, where the hero, something of a simpleton. is given such drugs following tests on a mouse, who ends up addressing a seminar of academic celebrati with extraordiunary iknpowledge of a huge range of subjects, beside him the mouse in its cage. Towards the end ofhis olecture/question session, the mouse starts to behave erratically and the final shot of the filmn is Cliff sitting forlornly gawping on a kiddies swing, reduced below where he had started off. Beware.

  17. #17 Therese
    May 29, 2008

    The film was just called Charly. It was based off the short story/novel, Flowers for Algernon, by Daniel Keyes.

  18. #18 Bwana
    June 12, 2008

    I wonder if anyone has been treated with Progivil for Obsessive Compulsive Disorder. It makes sense, if you think about it. Having an over-active mind, intrusive thoughts, etc. Would they be controlled or “ignored” with the help of Progivil? I don’t know; it would be worth looking into, though.

  19. #19 Paul
    July 3, 2008

    I have just started on Provigil a treatment for daytime sleepiness as a result of Obstructive Sleep Apnoea.
    I would warn all that Provigil is not without side effects indeed the insert that comes with the drug has a scarily long list.
    For my self it has stopped me dropping off but my BP has risen alarmingly and my heart rate frequently hits 122bpm at rest. Other warnings include strange thoughts and other physical effects. I’m on a low dose of 100mg twice a day and to be entirely honest while it keeps me awake it has done nothing for my concentration or memory.
    Given the side effects I’m suffering I would be seriously worried about anybody just picking it up and taking 200mg in one hit without medical advice. There are also warnings that prolonged use will cause a level of dependence.

    As to the post by KM the Physcosis you describe is classic sleep deprivation. It will happen to anybody deprived of sleep for long enough, that would range from 3 days to 7 depending on the individual. This is why sleep deprivation is used in interogation and torture, in this state people are more prone to suggestion.

  20. #20 Taylor
    August 8, 2008

    I have a concentration problem but it is not necessarily one of distractability. The problem I have is that as soon as I don’t understand something or in the case of a creative problem solving task, as soon as the next step is not obvious, I become anxious. This makes it unpleasant to continue to concentrate on the problem or to try to understand what I am reading.

    This seems to me to be an emotional problem as when I am feeling more self-assured I don’t become nearly as anxious when I don’t immediately understand something and so I am able to stay with it for much longer and to continue to make steady progress. I wonder if anyone has any thoughts on this phenomenon. I’m sure its emotional as opposed to having to do with chemistry or fatigue.

  21. #21 Happy
    September 6, 2008

    I have been on 300mg provigil for 3 years as I suffer from narcolepsy, The stuff is awesome, I have a near normal life again!! I have a few friends who have come across my prescribed stash and have taken them and as described above, Viagra for the brain, One downside….. I know im a long term user but watch the side effects, take a blood test now and then, Your Liver is quite an important organ.

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    For every story of people reporting that they are less creative while on stimulants I’ve heard just as many stories of people being more creative.

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    The thing is, the Irish users are, under this ruling, guilty until proven innocent, and the kicker is that they donÔÇÖt even have the chance to prove their innocence. The procedure thatÔÇÖs been put in place doesnÔÇÖt even allow them to try and defend themselves. As long as the Man *says* their downloading, then they are, thereÔÇÖs no attempt to substantiate the claims, no examination of evidence, hell they donÔÇÖt even have to provide evidence.
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  300. #317 sohbet
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  304. #321 youtube
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  320. #337 dizi izle
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    t’s an interesting theory, but that’s all it is. It might very well be that Modafinil increases focus without decreasing creativity – there are simply no studies to say one way or another.

    If I didn’t value my health, I might be tempted to do a trial ;)

    (To anybody who’s considering this: Taking a drag without knowing about long-term effects should be a last resort in dire health situations. Think about it long and hard before you go there)

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  339. #356 Michael
    September 28, 2009

    Provigil is a stimulant and I imagine it has similar side-effects to any other stimulant out there. Exercise, proper sleep and a diet(excluding stimulants you crackheads) is the best thing for mental clarity.

  340. #357 Heike
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    Provigil is a stimulant and I imagine it has similar side-effects to any other stimulant out there. Exercise, proper sleep and a diet(excluding stimulants you crackheads) is the best thing for mental clarity.

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  381. #400 video
    November 24, 2009

    Interesting Thery, but not my point of view. Anyway, nice article :)

  382. #401 ben 10 oyunlar─▒
    November 24, 2009

    Design is not art, that´┐Żs for sure. Design is one of the basic parts of the Engineering process which involves applying knowledge and resources to achive a desired objective.

  383. #402 film izle
    November 24, 2009

    Interesting post ToM. You said, ´┐Żit uses and alters the shot material of Brando without his consent or creative consultation.´┐Ż That might be somewhat difficult due to Brando´┐Żs being dead.

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  385. #404 sohbet odalar─▒
    November 24, 2009

    Design is not art, that´┐Żs for sure. Design is one of the basic parts of the Engineering process which involves applying knowledge and resources to achive a desired objective.

  386. #405 haber
    November 26, 2009

    its very nice and amazing project.

  387. #406 Sohbet
    November 26, 2009

    Design is not art, that´┐Żs for sure. Design is one of the basic parts of the Engineering process which involves applying knowledge and resources to achive a desired objective.

  388. #407 discount furiture
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  389. #408 erken rezervasyon
    November 28, 2009

    Provigil is not Ritalin. The only connection between the two mentioned in your article is this concept of “focus”. This is not a constant pervasive enough to allay the properties of one to the other. The two have massively different effects and chemistries. If your advise is founded on some reason, include it in the article. Otherwise you’re just peddling attractive crisis to helpless paranoiacs. This is not a responsible critique, it’s an overgeneralized paternalistic foreboding.

  390. #409 haber24
    November 30, 2009

    Provigil is not Ritalin. The only connection between the two mentioned in your article is this concept of “focus”. This is not a constant pervasive enough to allay the properties of one to the other.

  391. #410 sohbet odalar─▒
    November 30, 2009

    Interesting post ToM. You said, ?it uses and alters the shot material of Brando without his consent or creative consultation.? That might be somewhat difficult due to Brando?s being dead

  392. #411 sohbet
    November 30, 2009

    Provigil is a stimulant and I imagine it has similar side-effects to any other stimulant out there. Exercise, proper sleep and a diet(excluding stimulants you crackheads) is the best thing for mental clarity.

  393. #412 youtube
    December 6, 2009

    nteresting post ToM. You said, ?it uses and alters the shot material of Brando without his consent or creative consultation.?

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  395. #414 youtube
    December 9, 2009

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  396. #415 casting
    December 10, 2009

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  397. Thanks for posting about this, I would love to read more about this topic.

  398. #417 okey oyna
    December 11, 2009

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  399. #418 Antalya evden eve nakliyat
    December 11, 2009

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  400. #419 kral oyun
    December 15, 2009

    Interesting Thery, but not my point of view. Anyway, nice article :)

  401. #420 izlesene
    December 15, 2009

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  402. #421 lig tv izle
    December 15, 2009

    That might be somewhat difficult due to Brando?s being dead

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    December 17, 2009

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    December 19, 2009

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  419. #439 prash-n-rao
    January 2, 2010

    “In this case, the tradeoff involves creativity. Some of my friends who relied on crushed Ritalin during college used to joke about how the drugs were great for late-night cramming sessions, but that they seemed to suppress any kind of originality.”
    1. Drug X improves some aspects of thought processes
    2. Drug Y was also known to improve some aspects of thought processes
    3a. It seems to some people that drug Y decreased originality
    3b. I believe that such a cognitive trade-off would exist
    4. Therefore X also decreases originality (??)

    Aaaaarrrgggghhhh!!!!
    1. If the trade-off does exist normally, who knows, maybe Modafinil, or something else, works around it. To the best of my lay knowledge, the science of workings of brains and minds is not an exact science.
    2. Who says you have to take it all the time? You wear thinner clothes in summer and thicker clothes in winter, don’t you? Is there a such a thing as best all-weather clothing? (I don’t care if there is some sort of “best clothing”. I was just trying to point out fallacious reasoning)

    Another thing: Though I have seen enough articles linking schizophrenia (the author wrongly calls them “schizotypal subject”, quite laymanish of him) and creativity, it is wrong to believe that people without this disorder cannot be just as creative, or more creative than people with schizophreina.

  420. #440 ara├ž kiralama ankara
    January 3, 2010

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  421. #441 ara├ž sorgulama
    January 4, 2010

    Provigil is not Ritalin. The only connection between the two mentioned in your article is this concept of “focus”. This is not a constant pervasive enough to allay the properties of one to the other. The two have massively different effects and chemistries. If your advise is founded on some reason, include it in the article. Otherwise you’re just peddling attractive crisis to helpless paranoiacs. This is not a responsible critique, it’s an overgeneralized paternalistic foreboding.

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  425. #445 ara├ž sorgulama
    January 8, 2010

    You’re speculating though. My experience with modafinil tends say otherwise, too.

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    January 10, 2010

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    January 11, 2010

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    January 19, 2010

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  433. #453 kral oyun
    January 19, 2010

    But is there evidence that increasing attention with drugs decreases processing without awareness?

  434. #454 youtube
    January 20, 2010

    his is not a constant pervasive enough to allay the properties of one to the other. The two have massively different effects and chemistries. If your advise is founded on some reason, include it in the article. Otherwise you’re just peddling attractive crisis to helpless paranoiacs.

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  440. #460 chat
    January 30, 2010

    I prefer schokakola. Its the most effective chocolate in the World. One piece has more coffein than a mug coffee.

  441. #461 uydu
    January 31, 2010

    I’ve had a little experience with Provigil, and I found that: if one were to also use a little hash, one might find an interesting balance between focus and creativity.
    uydu

  442. #462 Ashok
    January 31, 2010

    But is there evidence that increasing attention with drugs decreases processing without awareness? Thanks……..

  443. #463 en g├╝zel oyunlar
    February 2, 2010

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  461. #481 siirt
    March 22, 2010

    Who says you have to take it all the time? You wear thinner clothes in summer and thicker clothes in winter, don’t you? Is there a such a thing as best all-weather clothing? (I don’t care if there is some sort of “best clothing”. I was just trying to point out fallacious reasoning)
    Thank you!

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    March 26, 2010

    Never saw something like that

  464. #484 araba oyunlar─▒
    March 26, 2010

    Just as I thoughtÔÇŽ freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.

  465. #485 Nagelstudio
    April 3, 2010

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  466. #486 Morbus Meniere
    April 3, 2010

    Interesting article… Wasn’t aware of all the background information.

  467. #487 Sohbet odalari
    April 5, 2010

    I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want

  468. #488 video izle
    April 9, 2010

    I’m to guessing the only way to do this in Js would be to use the onresize event, and then using the resize To method to attempt to keep the window at the size you want

  469. #489 Bursa Haber
    April 13, 2010

    If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone

  470. Just as I thoughtÔÇŽ freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.

  471. I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want

  472. #492 seo
    April 15, 2010

    I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want

  473. #493 jaluzi
    April 16, 2010

    The thing is, the Irish users are, under this ruling, guilty until proven innocent, and the kicker is that they donÔÇÖt even have the chance to prove their innocence. The procedure thatÔÇÖs been put in place doesnÔÇÖt even allow them to try and defend themselves. As long as the Man *says* their downloading, then they are, thereÔÇÖs no attempt to substantiate the claims, no examination of evidence, hell they donÔÇÖt even have to provide evidence.

  474. #494 Kemal
    April 19, 2010

    I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want http://www.gazikentmedikal.com

  475. #495 Kameral─▒ Sohbet
    April 25, 2010

    I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want

  476. #496 Almanya Sohbet
    April 25, 2010

    Just as I thoughtÔÇŽ freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.

  477. #497 Çet
    April 25, 2010

    his is not a constant pervasive enough to allay the properties of one to the other. The two have massively different effects and chemistries. If your advise is founded on some reason, include it in the article. Otherwise you’re just peddling attractive crisis to helpless paranoiacs.

  478. #498 sexy ladies
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  479. #499 oyun oyna
    April 27, 2010

    isney and spend their money of some Chinese Disney crap. Leave the rest of us alone

  480. #500 Hayata Dair Her┼čey
    April 28, 2010

    The rich get richer and the poor get poorer.

  481. #501 siki┼č izle
    April 28, 2010

    Just as I thoughtÔÇŽ freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.

  482. #502 Hayata Dair Her┼čey
    April 29, 2010

    I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want

  483. #503 spor
    May 1, 2010

    Interesting article… Wasn’t aware of all the background information.

  484. #504 SesliSohbet
    May 1, 2010

    The rich get richer and the poor get poorer. vayss

  485. #505 asik siteleri
    May 3, 2010

    CAER Director Rodney Andrews and researchers Tom Robl, Mark Crocker, Jim Neathery and Burt Davis met with the journalists in their separate laboratories, providing project descriptions and progress evaluations and answering questions during the morning-long tour.
    g├╝zel s├Âzler
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    a┼čk s├Âzleri
    A┼čk Mesajlari
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  486. #506 Tekne
    May 21, 2010

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  487. #507 Orjin Krem
    May 25, 2010

    The rich get richer and the poor get poorer.

  488. #508 Abaki Samsun
    May 27, 2010

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  489. #509 Muhabbet
    May 31, 2010

    I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want

  490. #510 a├Âf
    June 4, 2010

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  491. #511 sohbet odalar─▒
    June 9, 2010

    I’m guessing the only way to do this in Javascript would be to use the onresize event, and then using the resizeTo method to attempt to keep the window at the size you want

  492. #512 siki┼č
    June 10, 2010

    Just as I thoughtÔÇŽ freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.

  493. #513 tak─▒
    June 16, 2010

    Just as I thoughtÔÇŽ freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.

  494. #514 sohbet odalar─▒
    July 2, 2010

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  495. #515 dizi izle
    July 3, 2010

    Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.

  496. #516 mujeres rusas
    July 7, 2010

    I do think the time has come for people to consider looking into possible enhancements, but as you say, this won’t come without some sort of cost in another area. Potential health effects aren’t the only area of concern.

  497. #517 oyun oyna
    July 10, 2010

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  498. #518 film izle
    July 14, 2010

    Just as I thoughtÔÇŽ freedom of speech only applies to Republics and the Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.

  499. #519 Ambalaj
    July 18, 2010

    The rich get richer and the poor get poorer. very good

  500. #520 Gubatron
    July 18, 2010

    Given the original article has no comments, I’ll ask here.

    Where the hell can you buy it and try for yourself, online without getting scammed?

  501. #521 tak─▒
    July 19, 2010

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    July 21, 2010

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  503. #523 travesti
    July 24, 2010

    Right Wingnuts for which they stand. If this movie is a problem for these idiots, then they should just stay home or go visit Disney and spend their money of some Chinese Disney crap. Leave the rest of us alone. I tire of these idiots easily.

  504. #524 guzelsoz
    July 24, 2010

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    July 29, 2010

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  516. #536 Derrekito
    August 14, 2010

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  517. #537 Derrekito
    August 15, 2010

    Sorry, I forgot to mention that my response was meant to be toward Hari.

  518. #538 error fix
    August 16, 2010

    I’d agree that a trade-off makes sense in light of the context you received the information in, but do you have data to support that theory other than the anecdote of friends using a related but different substance?

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    August 18, 2010

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  520. #540 Electronic Cigarette
    August 19, 2010

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    August 21, 2010

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    August 23, 2010

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  524. #544 siyah peynir
    August 24, 2010

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  525. I’d agree that a trade-off makes sense in light of the context you received the information in, but do you have data to support that theory other than the anecdote of friends using a related but different substance?

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  529. #549 suskun
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  536. #556 photoshopsitesi
    September 28, 2010

    Sorry, I forgot to mention that my response was meant to be toward Hari.

  537. #557 kabin
    September 28, 2010

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    November 4, 2010

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    November 23, 2010

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    December 12, 2010

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    December 13, 2010

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