The Frontal Cortex

Dopaminergic Aesthetics

Natalie Angiers profiles dopamine, which isn’t just about rewards:

In the communal imagination, dopamine is about rewards, and feeling good, and wanting to feel good again, and if you don’t watch out, you’ll be hooked, a slave to the pleasure lines cruising through your brain. Hey, why do you think they call it dopamine?

Yet as new research on dopamine-deficient mice and other studies reveal, the image of dopamine as our little Bacchus in the brain is misleading, just as was the previous caricature of serotonin as a neural happy face.

In the emerging view, discussed in part at the Society for Neuroscience meeting last week in Chicago, dopamine is less about pleasure and reward than about drive and motivation, about figuring out what you have to do to survive and then doing it. “When you can’t breathe, and you’re gasping for air, would you call that pleasurable?” said Nora D. Volkow, a dopamine researcher and director of the National Institute on Drug Abuse. “Or when you’re so hungry that you eat something disgusting, is that pleasurable?”

In both responses, Dr. Volkow said, the gasping for oxygen and the wolfing down of something you would ordinarily spurn, the dopamine pathways of the brain are at full throttle. “The whole brain is of one mindset,” she said. “The intense drive to get you out of a state of deprivation and keep you alive.”

The caricature of dopamine as the chemical of hedonism and pleasure – it’s what drives us to enjoy sex, drugs and rock and roll – was always mostly misleading. While dopamine does predict the arrival of rewards, the neurotransmitter is much more important that. Many dopamine researchers, for instance, refer to the chemical as our “neural currency,” since it allows us to quickly assign a value to the multitudes of things and ideas in the outside world. (In other words, dopamine is the price tag of sensory information.) When we see something we want – and it doesn’t matter if it’s a chocolate cupcake or a glass of water – the mere sight of the object triggers a wave of emotional desire, which motivates us to act. (Emotion and motivation share the same Latin root, movere, which means “to move.”) The world is full of possibilities, and it is our dopaminergic feelings that help us choose between them.

And it’s not just chocolate cupcakes and lines of cocaine that make our dopamine neurons excited. In an oldish profile of Read Montague, a leading dopamine researcher at Baylor College of Medicine, he notes that one of the innovations of the human brain is that dopamine also evaluates abstract ideas:

From the perspective of the brain, an abstraction can be just as rewarding as the tone that predicts the reward. Evolution essentially bootstrapped our penchant for intellectual concepts to the same reward circuits that govern our animal appetites. “The guy who’s on hunger strike for some political cause is still relying on his midbrain dopamine neurons, just like a monkey getting a treat,” Montague says. “His brain simply values the cause more than it values dinner.” According to Montague, the reason abstract thoughts can be so rewarding, is that the brain relies on a common neural currency for evaluating alternatives. “It’s clear that you need some way to compare your options, even if your options come from very different categories,” he says. By representing everything in terms of neuron firing rates, the human brain is able to choose the abstract thought over the visceral reward, as long as the abstraction excites our cells more than apple juice. That’s what makes ideas so powerful: No matter how esoteric or ethereal they get, they are ultimately fed back into the same system that makes us want sex and sugar. As Montague notes, “You don’t have to dig very far before it all comes back to your loins.”

The purpose of pleasure, then, is to make it easier for the pleasurable sensation – the delicious taste, the elegant idea, the desired object – to enter the crowded theater of consciousness, so that we’ll go out and get it. That’s why we’ve got a highway of nerves connecting the parts of the dopamine reward pathway – the nucleus accumbens, ventral striatum, etc – to the prefrontal cortex. (This also means that a well-turned phrase or pretty painting will be more likely to get stuck in working memory, since it’s more rewarding. Aesthetics are really about attention.) Drugs like amphetamine and cocaine, which induce more dopaminergic activity, are chemical shortcuts: because those dopamine neurons in the midbrain are so excited – the neurotransmitter is skulking in the synapse – the world is suddenly saturated with intensely pleasurable ideas, which we can’t stop thinking about. We want to talk to everyone and touch everything. If attention is like a spotlight, then these drug makes the filament burn brighter. The end result is that we can’t look away.

Comments

  1. #1 NielsW
    October 27, 2009

    Interesting as always. The idea of a new post on your blog raises my dopamine levels, keep up the good work ;)

  2. #2 Julie Dirksen
    October 27, 2009

    Thanks for the explanation – I’ve know a while that the ‘caricature’ was wrong, but have been looking for better explanations. This is very helpful.

    Also, good motivation to sort the Read Montague book up to the top of the unread book pile.

  3. #3 royniles
    October 27, 2009

    Pleasure is perhaps a sensation that gives impetus to the pursuit of the anticipated desirable. Drugs supply the sensation that hijacks our anticipatory processes for the pursuit of the means themselves as more important than the ends we should have otherwise desired in accordance with our more beneficial needs. Short term and illusionary goals effectively replace the long term.

  4. #4 Nubia Lluberes
    October 27, 2009

    this idea goes along with Maslow’s hierarchy of needs. Maybe this path in research will bring some ideas about Bipolar disorder as well. What do you think?

  5. #5 Zathras
    October 28, 2009

    The amount of wild extrapolation in neuroscience publications certainly does something for my dopamine levels!

  6. #6 NCL
    October 28, 2009

    Seratonin has gotten all the attention when it comes to depression, but there are many of us out there who suffer because of our dopamiine neurotransmitters are malfunctioning. It is important to understand that depression is an extremely complicated disease which is why one drug, such as Prozac does not fit all

  7. #7 Pietr Hitzig
    October 28, 2009

    The addicted patient seeks dopamine not only to give pleasure but to relieve the pain of dopamine deficit. Unfortunately, increasing dopamine can itself be addictive or as Richard Pryor put it, “Cocaine makes a new man out of me and the new man wants cocaine.” Fortunately, actually inevitably, there is a neurotransmitter that inhibits behavior, serotonin.
    In 1993, I introduced Dr. Richard Rothman, director of National Institute of Addiction’s Intramural Research Program in Baltimore, to the idea that combined dopamine and serotonin agonists
    (CODAS) could treat addiction and other disorders. I have gone on and used levodopa and 5-HTP http://bit.ly/1jbLp2 the precursors of dopamine and serotonin, as the best way to manage same. Richard has gone in another direction. In this recent article http://bit.ly/18sElX he reviews the rationale behind CODAS and the dual deficit model of addiction and discusses the development of an agent that can do this effectively.

  8. #8 David
    October 28, 2009

    Superp blog, and even more so the following you’ve attracted. The dialog in the comments enhances the ideas, and definitely spikes the dopamine interest.

  9. #9 J
    November 13, 2009

    Sorry to comment so late after the post, but Kent Berridge’s research at the University of Michigan provides an important neural basis for the dissociation of ‘liking’ and ‘wanting’ within the nucleus accumbens. Endocannabinoids are more related to sensory pleasure than dopamine!

    His lab website is here, with the articles just a click away.

    http://www-personal.umich.edu/~berridge/

  10. #10 funkspiel
    December 20, 2009

    Perhaps they should add dopamine to the water supply to enhance our brains, as they did with fluorine for our teeth.

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