Stimulating the brain with high frequency electrical noise can supersede the beneficial effects observed from transcranial direct current stimulation, either anodal or cathodal (as well as those observed from sham stimulation), in perceptual learning, as newly reported by Fertonani, Pirully & Miniussi in the Journal of Neuroscience. The authors suggest that transcranial random noise stimulation may work by preventing those neurophysiological homeostatic mechanisms that govern ion channel conductance from rebalancing the changes induced by prolonged practice on this perceptual learning task.
In their wonderful Neuroimage article, Braun & Mattia present a comprehensive introduction to the possible neuronal implementations and cognitive sequelae of a particular dynamical phenomenon: the attractor state. In another excellent paper, just recently out in Frontiers, Itskov, Hansel and Tsodyks describe how such attractor dynamics may be insufficient to support working memory processing unless supplemented by rapid synaptic modification - a mechanism which has in fact been described neuroanatomically and previously utilized neurocomputationally to describe cognitive phenomena. To see how these ideas tie together a number of different neuroanatomical and cognitive discoveries, let's start with the basics of attraction.
If you ever said to yourself, "I wonder whether the human mid- and posterior ventrolateral prefrontal cortex has a homologue in the monkey, and what features of its cytoarchitecture or subcortical connectivity may differentiate it from other regions of PFC" then this post is for you.
Suppose - rather reasonably - that soups which taste like garlic have garlic in them. You observe two people eating soup; one of them says to the other, "There is no garlic in this soup." Do you think it's likely that the soup taste like garlic?
If you said yes, then congratulations! You've just committed a logical fallacy (from the premise "if p then q" and "not q," you have inferred p) so absurd that it's only very recently been given a name. But don't feel bad - this absurd inference, known as modus shmollens, can actually be elicited from a majority of adult human subjects when the situations are just right.
Last month's Frontiers in Psychology contains a fascinating study by Dambacher, Hübner, and Schlösser in which the authors demonstrate that the promise of financial reward can actually reduce performance when rewards are given for high accuracy. Counterintuitively, performance (characterized as accuracy per unit time) is actually better increased by financial rewards for response speed in particular.
Owing to the low signal-to-noise ratio of functional magnetic resonance imaging, it is difficult to get a good estimate of neural activity elicited by task novelty: by the time one has collected enough trials for a good estimate, the task is no longer novel! However, a recent J Neurosci paper from Cole, Bagic, Kass & Schneider circumvents this problem through a clever design. And the design pays off: the results indicate that the widely-hypothesized anterior-to-posterior flow of information through prefrontal cortex may actually be reversed when unpracticed novel tasks need to be prepared and performed. This result could have profound implications for our understanding what aspects of the prefrontal "division of labor" are dynamic based on abstract task features like novelty.
How do we detect important items in our environment? This crucial capacity has received less attention than one might think, and a number of extremely basic issues remain to be explored. For example, it has long been known that target probability has profound effects on the recruitment of the prefrontal cortex (such that lower-probability targets are associated with greater recruitment of both dorsolateral and ventrolateral prefrontal cortex), it has been unclear whether this pattern arises due to the general probability of the class of "targets" or whether it's more stimulus-specific.
An elegant new Neuroimage paper by Hon, Ong, Tan & Yang addresses this question across two experiments. As it turns out, they observe a suggestive difference between the dorsal and ventral subregions of lateral frontal cortex, such that the former area appears to be sensitive to the probability of individual targets whereas the latter area abstracts across individual targets and responds more clearly only to the probability of target items in general.
Sometimes, ground-breaking studies don't get the attention they deserve - even from experts in the field. One great example of this is an elegant study by Nieuwenhuis et al. from CABN in 2003; in it, they conclusively demonstrate why a particular event-related potential - the negative-going frontocentral deflection at around 200ms following stimulus onset, aka the "N2" - reflects the detection of response conflict, and not the demand to inhibit a response.
