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In which I present a quick guide for the omically challenged and a defense of 'arth and "ome."
Other SciBloggers have shared their thoughts on the use of ome here and here.
Sometimes I get frustrated too, with the way language is abused and tweaked by those around me. So many word pairs that once made phrases—log in, data set, file name, set up, and pick up—have been condensed into single words, that I've had to start using Google to double-check my editing. Perhaps it's surprising then, that I like "ome," "omics," and even Sydney Brenner's chief phrase-to-hate, "systems biology."
I like "ome" because it simultaneously gives us more precise definitions for fields of study, while making a distinction between the reductionist view of biology, that was so popular when I was in graduate school, and the more global-omic-view that's been emerging of late. When I grew up, we were mired in the one gene - one enzyme rut. We spent our time focused on single genes, single enzymes, single bands in gels, etc. It sounds funny now, but we actually questioned whether it made sense to sequence DNA if we didn't know the function first.
Besides, "ome" sounds like "ribosome" and "spliceosome" and I've always liked those molecular machines, so why not head towards ome?
Whatever you think about ome, I've compiled a table of the omics I know of to help translate some of the old standby words into today's omics.
Disclaimer: These are the definitions as I understand them, feel free to add suggestions and corrections in the comment section, if I like them I'll add them to the table.
[updated 12/1/2006 thanks to Alex!]
| Ome | Definition | Field | Techniques | Old word |
| Genome | All the genes in an organism. | Genomics | DNA sequencing, DNA assembly, BLAST, tools for translating open reading frames | genetics |
| Comparing genomes from different organisms | Comparative genomics | BLAST, tools for drawing maps | genetics | |
| All the structures of molecules in an organism. | Structural genomics | X-ray diffraction, NMR | biochemistry | |
| Transcriptome | All of the transcripts (RNA) produced by an organism | Quantitative PCR, ESTs, microarrays, cDNA libraries | genetics | |
| Proteome | All the proteins in an organism. | Proteomics | 2D gels, mass spectroscopy | biochemistry |
| Metabolome | All the biochemical pathways in an organism | Metabolomics | Enzyme assays | biochemistry |
| Secretome | All the molecules involved in secreting substances from a cell. | cell biology | ||
| Kinome | All the molecules that can be phosphorylated, and the enzymes (kinases and phosphatases) that add or remove phospates. (is this last part correct?) | cell biology | ||
| Glycome | All the molecules that can be glycosylated, and the enzymes that carry out these reactions. | cell biology | ||
| Ubiquitome | All the molecules that can be ubiquinated, and the enzymes that carry out these reactions. | cell biology | ||
| Venome | All the peptides in venom. | zoology |
technorati tags: omics, ome, genomics, proteomics, metabolomics
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Comments
In my written prelims back in 1999, I suggested that sooner or later there will be an organismome...until someone whispers that the term "physiology" already exists.
Posted by: coturnix | December 1, 2006 01:47 PM
Sydney Brenner says that "systems biology" is physiology in disguise.
Posted by: Sandra Porter | December 1, 2006 02:08 PM
That's it? How about kinome (all the kinases), ubiquitome (all the ubiquitinated proteins), phosphome (all the phosphorylated proteins) and glycome (all the glycosylated proteins). It's getting ridiculous. To the point that I can't take any new 'omic coinage seriously ...
BTW "some" (as in ribosome, spliceosome, centrosome or even soma) comes from the greek word for "body" (soma=neuron cell body). Genome cames from the fusion of "gene" and "chromosome" (the later meaning colored body in greek - DNA can be stained with various dyes). I forgot who came up with that. But in light of this ... what does the word metabolome have to do with a cell body???
Posted by: apalazzo | December 1, 2006 08:59 PM
cames = came (sorry 'bout that typo)
Posted by: apalazzo | December 1, 2006 09:01 PM
Alex: Thanks for the additions! I added them to the table - I'm still wondering if I can count the enzymes that add sugars as part of the glycome, ubiquitin as part of the ubquitome, kinases and phosphatases as part of the kinome, etc.
If anyone knows, I do want the answer.
Also - I think a "metabolome" could be the body of metabolic reactions that take place in a cell.
Posted by: Sandra Porter | December 1, 2006 10:25 PM
We study the complex mixture of small peptides present in the venom of Atracinae spiders, the "venome".
Posted by: PhysioProf | December 2, 2006 06:09 PM
oooh, venome! I like it!
Posted by: Sandra Porter | December 2, 2006 06:29 PM