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Discovering Biology in a Digital World

My thoughts on biology, teaching, life, and exploring the living world via the digital one. Only my opinions are represented by these postings, they do not represent the viewpoints of any funding agency or Geospiza, Inc.

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Sandra Porter I am a microbiologist and molecular biologist turned tenured biotech faculty turned bioinformatics scientist turned entrepreneur. My passion is developing instructional materials for 21st century biology (Geospiza Education).

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  • xkcd
  • The Tangled Bank
    MicrobeWorld Radio

    Ask Dr. Science:

    I eat genomes for breakfast

    And so do you.

    Does anyone know this jellyfish by name?

    A reader from the UK sent me these lovely photos that he took of a jellyfish and asked for my help in identifying it. Unfortunately, while I'm pretty good with bacteria, plants, and tropical fish, my taxonomy skills don't go much farther unless I have a sample of DNA. These photos were taken at La-Manga off the coast of southern...

    Why is sequencing a human genome so expensive?

    Adding the costs and doing the math.

    What made me sick?

    How do microbiologists determine which microbe caused a disease? As Tara has eloquently described (I, II), we are covered with bacteria and other microbes. A reasonable question then, is when we get sick, how do we which little devil deserves the blame?...

    What are hypothetical and putative proteins?

    "Beware the Jabberwock, my son! The jaws that bite, the claws that catch! Beware the Jubjub bird, and shun The frumious Bandersnatch!" - from Jabberwocky, by Lewis Carroll I'm certain that if we ever sequenced DNA from the frumious Bandersnatch it would match hypothetical and putative proteins....

    Sequencing a Genome, part VII: Want to win $10 million dollars?

    How to win the X PRIZE in genomics In October, 2006, the X PRIZE foundation announced that second X prize would focus on genomics. The first team to successfully sequence 100 human genomes in 10 days will win $10 million dollars. And I would venture to guess, that the winning team would also win in the IP (intellectual property) game...

    Biology as a second language: what is a vector?

    Defining a biology term for scientists in other disciplines.

    Sequencing a Genome, part VI: Chimeras are not just funny-looking animals

    Chimeras invade the sequencing lab!

    Sequencing a Genome, part V: checking out the library

    Send in the clones, but only the random ones.

    Basics: How do you sequence a genome? Part IV. How many reads does it take?

    "How deep is the ocean? How high is the sky?"

    Basics: How do you sequence a genome? part III, reads and chromats

    In which we define reads, chromatograms, and shotgun sequencing.

    Basics: How do you sequence a genome, part II

    Some background on the strategies: mapping vs. shotgun

    Basics: How do you sequence a genome?

    Ask Dr. Science: yes, I do take requests.

    What is a gene? My definition is better

    In the effort to help us define a few basic concepts, PZ started out by giving us a nice simple definition of a gene, but as he, rightly noted: I tell you right now that if I asked a half dozen different biologists to help me out with this, they'd rip into it and add a thousand qualifiers, and it...

    Ask Dr. Science!

    or you can try asking me.

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