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Genetics & Molecular Biology

Category archives for Genetics & Molecular Biology

What tells us that this new form of H1N1 is swine flu and not regular old human flu or avian flu? If we had a lab, we might use antibodies, but when you’re a digital biologist, you use a computer. Activity 4. Picking influenza sequences and comparing them with phylogenetic trees

This afternoon, I was working on educational activities and suddenly realized that the H1N1 strain that caused the California outbreak might be the same strain that caused an outbreak in 2007 at an Ohio country fair. UPDATE: I’m not so certain anymore that the strains are the same. I’m doing some work with nucleic acid…

I was pretty impressed to find the swine flu genome sequences, from the cases in California and Texas, already for viewing at the NCBI. You can get them and work them, too. It’s pretty easy. Tomorrow, we’ll align sequences and make trees. Activity 3: Getting the swine flu sequence data

I’m a big of learning from data. There are many things we can learn about swine flu and other kinds of flu by using public databases. In digital biology activity 1, we learned about the kinds of creatures that can get flu. Personally, I’m a little skeptical about the blowfly, but… Now, you might wonder,…

Genome sequences from California and Texas isolates of the H1N1 swine flu are already available for exploration at the NCBI. Let’s do a bit of digital biology and see what we can learn. Activity 1. What kinds of animals get the flu?

A couple of years ago, I answered a reader’s question about the cost of genome sequencing. One of my readers had asked why the cost of sequencing a human genome was so high. At that time, I used some of the prices advertised by core labs on the web and the reported coverage to estimate…

In which we search for Elvis, using blastp, and find out how old we would have to be to see Elvis in a Las Vegas club.

For the past few months, the shake-up that began with Next Generation DNA Sequencing has been forcing me to adjust to a whole new view of things going on inside of a cell. We’ve been learning things these past two years that are completely changing our understanding of the genome and how it works and…

What do the missing Romanov children, genetically engineered humans, financial risk taking, and poop have in common? You can read about all these topics from this month’s Gene Genie carnival at Mary Meets Dolly. Who would have thought that mutations could be so much fun?

A long-sought goal in genetics has been to develop therapies that can use correctly functioning genes to replace genes with defects. If we had the technology to predictably modify our genomes, we would have the ability to cure many diseases instead of having to place people on medications for their entire lives. For a long…