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Genomics

Category archives for Genomics

“By night all cats are gray”  – Miguel Cervantes in Don Quixote   I’ve always liked Siamese cats.   Students do, too.  “Why Siamese cats wear masks” is always a favorite story in genetics class.  So, when I opened my January copy of The Science Teacher, I was thrilled to see an article on Siamese cat…

We’ve been fans of the Molecule of the Month series by David Goodsell, for many years. Not only is Dr. Goodsell a talented artist but he writes very clear descriptions of the ways molecules like proteins, RNA, and DNA work together and function inside a cell. To learn about proteins and their activities, I like…

National DNA Day has a fun challenge for teachers and classrooms using Pinterest.  Your class can join a larger, national, effort to create a National DNA Day Pinterest board by making your own class Pinterest board on DNA, genetics, and genomics.  Some possible topics are: Things to do with DNA DNA and health DNA and the Arts…

Bio Databases 2015

Something interesting happened in 2014. The total number of databases that Nucleic Acids Research (NAR) tracks dropped by three databases! What happened?  Did people quit making databases?  No.  This year, the “dead” databases (links no longer valid) outnumber the new ones. To celebrate Digital World Biology’s release of Molecule World I’ll discuss some of the new structure databases…

Sometimes when you go digging through the databases, you find unexpected things. When I was researching the previous posts on insulin structure and insulin evolution, I found something curious indeed.                     I wanted to find out how many different organisms made insulin, so I used a database…

On pinene and inhibiting enzymes. People of a certain age may remember a series of really funny commercials featuring Euell Gibbons and his famous question about whether you’ve ever eaten a pine tree.  “Some parts are edible” said Euell. Perhaps some parts are, but other pine tree products aren’t so nourishing.  Crystallography365, aka @Crystal_in_city  had a couple of…

Scale, proportion, and quantity belong to one of the cross cutting concepts in the next generation science standards (NGSS).  According to Volume 2 of the NGSS, “in engineering, no structure could be conceived much less constructed without the engineer’s precise sense of scale.”  The authors go on to note that scale and proportion are best understood using…

Science and its interpretation is wonderful. Today I saw a post on Twitter from @LAbizar, referencing an @GEN, post that stated 8.2% of Human DNA is Functional with a link to a GEN article: “Surprise: Only 8.2% of Human DNA Is Functional.” The GEN writeup cited a PLoS Genetics article, “8.2% of the Human Genome Is Constrained: Variation in Rates of…

A few weeks back, we published a review about the development and role of the human reference genome. A key point of the reference genome is that it is not a single sequence. Instead it is an assembly of consensus sequences that are designed to deal with variation in the human population and uncertainty in…

A key concept in science is molecular scale. DNA is a fascinating molecule in this regard. While we cannot “see” DNA molecules without the aid of advanced technology, a full length DNA molecule can be very long. In human cells, other than sperm and eggs, six billion base pairs of DNA are packaged into 22…