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Genomics

Category archives for Genomics

I’ve heard you have to sing loud if you want to change the world. Cloning DNA – lyrics by Sandra Porter, sung to the tune of Surfin’ USA C ………………G7………………C If everybody had a plasmid, across the U.S.A., C ………………G7………………C then everybody’d be cloning, with their DNA …………………………..F You’d see them wearing their goggles. ………………..…

In simple Mendelian genetics, a single change in one gene can produce a large change in mortality. The National Human Genome Research Institute (NHGRI) will be funding genomics studies on Mendelian traits using a similar strategy. NHGRI will fund a small number of centers, dominant centers you might say, and look for large changes. The…

For the past few days I’ve been avidly following Daniel MacArthur’s tweets from the Personal Genome Conference at Cold Spring Harbor(@dgmacarthur #cshlpg). The Personal Genomics tweets aren’t just interesting because of the science, they’re interesting because MacArthur and others have started to take on the conventional dogma in genetic ethics. For years, there has been…

This morning I attended a “bloggers-only” conference call with Dr. Eric Green and the folks from the NIH Human Genome Research Institute (NHGRI) to hear about NHGRI’s new strategic plan. The new plan represents a shift away from viewing the genome through a lens marked “for research use only” and towards the goal of making…

I had the good fortune on Thursday to hear a fascinating talk on deep transcriptome analysis by Chris Mason, Assistant Professor, at the Institute for Computational Biomedicine at Cornell University.  Several intriguing observations were presented during the talk.  I’ll present the key points first and then discuss the data. These data concern the human transcriptome,…

One of my hobbies lately has been to get either RNA seq or microarray data from GEO and do quick analyses. Not only is this fun, I can find good examples to use for teaching biology. One of these fun examples comes from some Arabidopsis data. In this experiment, some poor little seedlings were taken…

Blaine Bettinger has an absolutely wonderful post where he compares his results for type 2 diabetes from 23andMe and DeCODEme. I really liked his post and I appreciated the way he showed the data from the two companies and elaborated on their interpretation of his genotype and his risk. Interestingly, his story goes beyond a…

An NSF post on Twitter this morning described an interesting study from the University of Pennsylanvia and Cornell University, that found that some people who call themselves “African Americans” may only be 1% West African, according to their DNA. The University of Pennsylvania press release contains other interesting findings as well. 365 individuals were studied…

You might think the coolest thing about the Next Generation DNA Sequencing technologies is that we can use them to sequence long-dead mammoths, entire populations of microbes, or bits of bone from Neanderthals. But you would be wrong.

One of the interesting things I learned today was that many people are calling for the genome sequences of the chimps and Macaques to be finished. This is especially amusing because the human genome isn’t quite done. We’re primates, too! Why not finish our genome?