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What Happens at the End?

Organisms with linear chromosomes have to solve the problem that DNA replication makes them shorter. This is due to the fact that DNA polymerase can only add bases to the terminal 3′-OH of a DNA chain. The DNA replication initiation complex uses RNA primers to provide the initial 3′-OH and to initiate “lagging” strand synthesis.…

The A, B, Z’s of DNA

Today (4/25) is national DNA day.  Digital World Biology™ is celebrating by sharing some of our favorite structures of DNA. We created these photos with Molecule World™ a new iPad app for viewing molecular structures. As we are taught in school, the double stranded DNA molecule is a right-handed helix as determined by Watson and Crick using…

In our series on why $1000 genomes cost $2000, I raised the issue that the $1000 genome is a value based on simplistic calculations that do not account for the costs of confirming the results. Next, I discussed how errors are a natural occurrence of the many processing steps required to sequence DNA and why…

Could you repeat that please?

Previously, I introduced the idea that the $1000 genome has not been achieved because it is defined in simplistic terms that ignore many aspects of data completeness and verification. In that analysis, I cited a recent perspective by Robasky, Lewis, and Church [1] to present concepts related to the need to verify results and the…

$1000 Genomes for $2000

Getting an accurate genome sequence requires that you collect the data at least twice argue Robasky, Lewis, and Church in their recent opinion piece in Nat. Rev. Genetics [1]. The DNA sequencing world kicked off 2014 with an audacious start. Andrew Pollack ran an article in the New York Times implying that 100,000 genomes will…

Bio Databases 2014

By @finchtalk (Todd Smith) In 2014 and beyond Finchtalk will be contributing to Digitalbio’s blog at this site. We kick off 2014 with Finchtalk’s traditional post on the annual database issue from Nucleic Acids Research (NAR). Biological data and databases are ever expanding. This year was no exception as the number of databases tracked by…

Yesterday, I wrote about students using science blogging as a way to develop an on-line portfolio and document their skills.  One friend wrote me this morning and asked if my instructions to our students were really as simple as I described. Well, no. In fact, it wasn’t easy to persuade my colleagues that we should…

Why should students blog about science?  Don’t they have enough to do already? Last Thursday night I participated in a panel discussion about science blogging (see the video) at ScienceOnline Seattle (#scioSEA)(video) and mentioned that we have two students blogging for us at Bio-Link.  A question I saw afterward via Twitter, from @NurhafizPiers was this: what…

Tonight, I’m going to be speaking on a panel at the University of Washington with fellow science bloggers: Alan Boyle (@b0yle) from CosmicLog and some company called “NBC” news. (I only watch TV programs on Netflix and iTunes, these days, so I forget TV stations still exist.) Brendan DeMelle (@bdemelle) from DeSmog Blog, and the Huffington Post and Adrienne Roehrich (@fiainros) from Double X…

If you want to work in biotech, you have to get work experience. But, how do you find it? One way to find work experience is to do an internship. When do I look? If you’re a college student, and you’re planning to wait until spring to apply for a summer internship, you’re waiting too…