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Discovering Biology in a Digital World

My thoughts on biology, teaching, life, and exploring the living world via the digital one. Only my opinions are represented by these postings, they do not represent the viewpoints of any funding agency or Geospiza, Inc.

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Sandra Porter I am a microbiologist and molecular biologist turned tenured biotech faculty turned bioinformatics scientist turned entrepreneur. My passion is developing instructional materials for 21st century biology (Geospiza Education).

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    teaching:

    Starting a new biotech program? Teaching a biotech course?

    Bio-Link is accepting applications for this year's National Summer Fellows forum, June 2-6th, in Berkeley, CA. You can get an application at www.bio-link.org I'll be there, doing some kind of bioinformatics workshop. I'll probably be talking about either metagenomics or comparing protein structures and drug resistance, but if you have topic requests, feel free to submit them in the comments....

    Exploring Open Office: part II, can we have our pie and eat it too?

    I've been writing quite a bit this week about my search for a cross platform spread sheet program that would support pivot tables and make pie graphs correctly. This all started because of a bug that my students encountered in Microsoft Excel, on Windows. I'm not personally motivated to look for something new, since Office 2004 on Mac OS 10.5...

    The OpenOffice challenge: can you do what needs to be done?

    Okay OpenOffice fans, show me what you can do. Earlier this week, I wrote about my challenges with a bug in Microsoft Excel that only appears on Windows computers. Since I use a Mac, I didn't know about the bug when I wrote the assignment and I only found out about it after all but one of my students turned...

    Linux is amusing, but this is why I teach with Excel

    The other day, I wrote that I wanted to make things easier for my students by using the kinds of software that they were likely to have on their computers and the kinds that they are likely to see in the business and biotech world when they graduate from college. More than one person told me that I should have...

    An unexpected challenge with teaching on-line

    Three (or more) operating systems times three (or more) versions of software with bugs unique to one or systems (that I don't have) means too many systems for me to manage teaching. Thank the FSM they're not using Linux, too. (Let me see that would be Ubuntu Linux, RedHat Linux, Debian Linux, Yellow Dog Linux, Vine, Turbo, Slackware, etc.. It...

    Bacterial metagenomics on the JHU campus: analyzing the data, part I

    For the past few years, I've been collaborating with a friend, Dr. Rebecca Pearlman, who teaches introductory biology at the Johns Hopkins University. Her students isolate bacteria from different environments on campus, use PCR to amplify the 16S ribosomal RNA genes, send the samples to the JHU core lab for sequencing, and use blastn to identify what they found. Every...

    A quick introduction to BLAST

    A quick video introduction to BLAST.

    Ruminating on the digital divide

    A few weeks ago I attended a education conference at Pacific Science Center entitled, "A Conversation that Can Change the World."...

    Where do you go to learn SQL? I go to the zoo

    A long standing debate in my field is whether or not biologists, who work with computers, need to learn how to program. I usually say "no." Let the programmers program, the biologists interpret the results, and let everyone can benefit from each other's expertise. Well, I've changed my mind in one respect. Most biologists need to work with some kind...

    Interpreting DNA sequencing data: answers to the quiz

    Which read(s): 1. contain either a SNP (a single nucleotide polymorphism) or a position where different members of a multi-gene family have a different base? C 2. doesn't have any DNA? B 3. is a PCR product? A, B, and C.  All of three reads were obtained by sequencing PCR products, generated with the same set of primers. The quality...

    Interpreting DNA sequencing data: what can you get from quality scores?

    Kind of like reading tea leaves, but more meaningful.

    Digital Biology Friday: Animal Mitochondria and Evolution, part II

    You too, can compare chimp and human DNA.

    Match the trace with the sample

    Can you do it? This is what bioinformatics technicians or data analysts do in diagnostic labs.

    Before practicing on real patients, you can practice in Second Life

    The Wired Campus has an interesting article on nursing students at Tacoma Community College. In John Miller's class, the students practice interviewing patients in Second Life. This sort of activity, of course, is one that could be carried out in a classroom, but I can see the advantages of having student interview other "people" who are for the most part,...

    Evidence-based teaching, open access, and the digital divide

    Open access to educational research would benefit us all.

    Digital Biology Friday: Animal Mitochondria and Evolution Revisited

    An evolution activity for the classroom.

    Digging up the dirt on campus bacteria: how do we know if we have good data?

    Metagenomics is a field where people interrogate the living world by isolating and sequencing nucleic acids. Since all living things have DNA, and viruses have either DNA or RNA, we can identify who's around by looking at bits of their genome. Researchers are using this approach to find the culprit that's killing the honeybees. We're also trying to find out...

    Metagenomics, biomes, and dirt: separating good data from bad

    Sequencing the dirt: see how it's done

    Making discoveries in the open: doing digital biology with the class

    Would you like to have some fun playing with chromatograms and helping our class identify bacteria in the dirt?...

    Computers vs. the science class: IT 1, Instructor 0

    It's hard to teach bioinformatics when schools work so hard to keep us from using computers....

    Help for educators with exploring new worlds

    If like me, you were a little disoriented and confused when you visited Second Life and traveled through orientation island, then you may like this....

    How to attend a poster session in Second Life

    Bora and I are giving posters in Second Life. Here's how you can attend.

    MicrobeWorld: what have you done?

    For the record: Chlamydia is NOT a virus. I am bummed. I like the little MicrobeWorld radio broadcasts, and the video podcasts are even more fun. But I was perusing the archives and I found this:...

    Biology as a second language, Nature podcasts, and why fireflies glow in the dark

    Why I love Nature podcasts

    Digital Biology Friday: You make the call!

    Developing "biological intuition" through case studies

    Bug hunting is a BLAST

    Software testing and the scientific method.

    Making course evaluations useful

    Do course evaluations have to be a popularity contest? Or can they be useful tools for improving a class? tags: teaching, student evaluations A few days ago, evolgen lamented that his students weren't giving him useful information on their end-of-course evaluations. I'm not surprised. When I first started teaching, I was a given a copy of the standard-teacher-evaluation-form-that-everyone-used....

    Learning styles and science labs

    Science labs are not for all people.

    Opening up new VISTAs

    I received a mysterious file last week, via e-mail from one of my students. According the e-mail, the file contained the answers to an assignment....

    Bioinformatics for biotech students: my favorite computer programs

    The bioinformatics classes that I teach use web services and web sites as much as possible, but I still find that it's helpful to have programs on our classroom computers. Here is a list of my favorite desktop programs for those of you who might want to add some bioinformatics activities to your biology courses....

    Snow Day!

    I was frantically getting ready for class when I happened to glance out the window. What did I see? Big fluffy white flakes rapidly falling from above. You can't say we weren't warned. The newspapers have been predicting snow since Monday. It's just, well, unusual. And Seattle is never prepared to deal with it. Even the kids aren't looking too...

    My equipment wish-list for teaching bioinformatics

    There's nothing like the first day of class to make you appreciate the difference between the equipment you end up using at schools and the equipment that you get to use on the job. For the month of January, I'm teaching a night class in bioinformatics at a local community college. We're introducing lots of web-based programs, and databases, and...

    Let's watch that again in slow motion, shall we?

    We need lab movies of people doing things wrong.

    Things that go wrong in the lab

    Like sex education in a religious household, lab technique must sometimes be learned from your friends.

    Doing your lessons in blood

    typing that is.

    While students do forensics, I dissect the class

    The blood typing lab, part I. What went wrong? and why? Blood typing part II. Can this laboratory be saved? Those wacky non-major Zoo students are at it again! And this time they drew blood! Mike's undergraduate students learned about blood typing, a common tool of detectives and real crime TV. They did the classic blood typing lab, and by...

    Teaching science, scientifically

    Why not use a scientific approach to teaching?

    It's not the subject, it's the teaching

    Students don't leave science because it's too hard, or too easy, students leave science because of the way that it's taught.

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