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Next Generation DNA sequencing

Tag archives for Next Generation DNA sequencing

In our series on why $1000 genomes cost $2000, I raised the issue that the $1000 genome is a value based on simplistic calculations that do not account for the costs of confirming the results. Next, I discussed how errors are a natural occurrence of the many processing steps required to sequence DNA and why…

I had the good fortune on Thursday to hear a fascinating talk on deep transcriptome analysis by Chris Mason, Assistant Professor, at the Institute for Computational Biomedicine at Cornell University.  Several intriguing observations were presented during the talk.  I’ll present the key points first and then discuss the data. These data concern the human transcriptome,…

These days, DNA sequencing happens in one of three ways. In the early days of DNA sequencing (like the 80’s), labs prepared their own samples, sequenced those samples, and analyzed their results. Some labs still do this. Then, in the 90’s, genome centers came along. Genome centers are like giant factories that manufacture sequence data.…

A couple of years ago, I answered a reader’s question about the cost of genome sequencing. One of my readers had asked why the cost of sequencing a human genome was so high. At that time, I used some of the prices advertised by core labs on the web and the reported coverage to estimate…

Watching the chIPs roll in, then I watch them roll away again, I’m just sitting on the DNA, wasting time (sung to the tune of “Sitting on the dock of the bay” by Otis Redding) Hesselberth et.al. recently published a paper about digital genomic footprinting that blew me away because it has so much potential.…

For the past few months, the shake-up that began with Next Generation DNA Sequencing has been forcing me to adjust to a whole new view of things going on inside of a cell. We’ve been learning things these past two years that are completely changing our understanding of the genome and how it works and…

Cofactor Genomics is offering to sequence a genome for a few classes for free using Next Generation DNA Sequencing technology (either Illumina GA or via AB SOLiD). Quoting from their site: Cofactor will ask course organizers for a 1 page description of how their ~700Mb sequencing project could be used as an effective teaching aid…

One of my favorite web 2.0 technologies is the webinar. When you work at a company and not a University, with constant seminars, it gets a bit harder to hop on a bus and travel across town to learn about new things. Webinars are a good way to fill that gap. I grab my coffee…

It’s a Solexa data directory. I’ve held off on blogging about Next Generation Sequencing here, but now that one of my colleagues has started blogging about it, it seems like a good time to write a little about FinchTalk, our company blog. We’ve decided that we can serve an educational role for people who are…