Effect Measure

Swine flu in a cat and other matters

Helen Branswell, the Canadian Press’s extraordinary flu reporter, is one of the few reporters who could have written the article, “Flu dogma being rewritten by a strange virus no one pegged to trigger a pandemic”. She’s been following flu for years and has watched as one thing after another we thought we knew about flu has been shown wrong — by the flu virus. It’s a theme we have been sounding as well for almost as long. As scientists we’ve seen one alleged flu truism after another was stood on its head. A couple of years ago we began to assume anything said about flu was provisional. Some of it might turn out to be true, and some of it might not. If you’ve been following this blog for a few years, most of Branswell’s material will be familiar, but she has pulled it together in one place. So read it (once again: here). But one piece of now outmoded conventional flu wisdom not is in Branswell’s article — because it was only announced Wednesday — is that our beloved household companion animals (aka, “pets”) aren’t susceptible to swine flu (example here, with breaking news update to correct it). This may still be flu dogma, but it’s no longer flu catma.

From the Iowa Department of Public Health:

The Iowa Department of Public Health (IDPH) and the Iowa Department of Agriculture and Land Stewardship (IDALS) remind Iowans that in addition to protecting their families, friends and neighbors from the spread of the 2009 H1N1 influenza virus, it?s important to remember to protect family pets from the illness, as well. People who are sick with H1N1 can spread the virus not only to humans, but to some animals.

The Departments are sharing this message following the confirmation of a case of H1N1 in an Iowa cat. (IDPH)

Reporter Tara Parker-Pope has more in an excellent article in The New York Times:

A few days after two members of an Ames, Iowa, family came down with the flu, they noticed their 13-year-old cat wasn?t feeling too well either. The cat has since become the first documented case of a feline with the new H1N1 virus, commonly called swine flu.

The unusual case has riveted pet owners and health officials. Companion animals have been known to contract flu from other species ? canine influenza (H3N8) originated in horses, and cats contract avian influenza (H5N1) from eating birds. But this appears to be the first time a cat has contracted influenza from a human. Two pet ferrets, one in Oregon and one in Nebraska, have also tested positive for H1N1, and the virus has also been transmitted between humans and pigs.

[snip]

The cat, a 16-pound orange tabby, began acting lethargic and lost his appetite on Oct. 27. He is the only pet in the house and never goes outside. The cat, described as ?large framed but not chubby,? stopped eating and drinking and stopped cleaning himself. He also rested by hunching on all four feet, rather than sprawling out on his side as usual, a sign of respiratory discomfort. A few days earlier, two out of three family members in the home had developed flu-like symptoms, with fever and body aches.

The worried pet owner called Dr. Sponseller, a specialist in large animal internal medicine and molecular virology, who happened to be a family friend. At the time, neither Dr. Sponseller nor the pet owner suspected the flu . . .

[snip]

Although cats can contract flu from birds, this cat never left the house and was never exposed to any other pet. At that point, it occurred to the veterinarians that since the family members had been recently ill, they might be seeing a case of flu transmitted from human to cat. The school is the site of a major diagnostic lab, so the veterinarians were able to test the cat and quickly confirm he had H1N1, a finding that was later confirmed by additional testing by the U.S. Department of Agriculture. (Tara Parker-Pope, New York Times)

This was clearly a serendipitous discovery. This cat’s household had connections to sophisticated veterinary science. Otherwise we wouldn’t know about it. Which means that lots of animals may be getting this virus but we haven’t recognized it. Besides humans, the known list includes free-living (i.e.,not in labs) pigs, ferrets, turkeys and cats. So when I read a briefing by WHO entitled, “Infection of farmed animals with the pandemic virus,” I no longer take it seriously:

To date, extensive testing by laboratories in the WHO influenza surveillance network has detected no signs that the H1N1 pandemic virus has mutated to a more virulent form. Currently licensed pandemic vaccines closely match circulating viruses and are expected to confer good protection.

Vigilance for changes in the H1N1 virus includes monitoring to detect possible influenza infections in susceptible animals, both mammals and birds, as well as humans. While most influenza A viruses circulating in mammals preferentially infect a single species, cross-species transmission is known to occur. (WHO 2009 briefing note 15)

WHO’s proposition that extensive testing in laboratories shows no signs H1N1 has mutated to a more virulent form implies we can recognize when this is occurring. It would be grand news if true, that we could simply read the biology off the genetic sequence. We’re nowhere near that point. Trying to predict what this virus will do or not do from looking at genetic sequences is currently beyond our abilities. How do I know this? The virus has told us. Again and again. The second paragraph acknowledges that other species can be involved, but you certainly don’t get the idea that this is something likely to happen, just something to watch for. But surveillance in other species is sparse (even for pig viruses there is little surveillance data available, much less other animals, except for birds).

There are some real concerns here. This is the era of industrial farming, with thousands or tens of thousands of susceptible animals (birds and pigs) under great stress crammed together. A virus can become extremely virulent and kill an animal very quickly yet still successfully transmit to another animal under these circumstances. If it’s a virus that can also infect humans, this is a public health problem. Yet WHO says:

In addition, pandemic H1N1 infections have been reported in turkeys in Chile and Canada and in a few pet animals in the USA. Again, these infections were isolated events and pose no special risks to human health. (WHO 2009 note 15)

Maybe this is correct. But it’s a wish more than an established fact, as the following section of the same note suggests:

When influenza infections are detected in farmed animals, WHO recommends monitoring of farm workers for signs of respiratory illness, and testing for H1N1 infection should such signs appear. FAO and OIE recommend that animals that are showing signs of illness be examined and properly managed, and allowed to fully recover before being transported or marketed.

In addition, samples from infected animals and humans should be taken for full genome sequencing of the influenza viruses to determine if mutations have occurred that could lead to changes in virulence, host range or antiviral resistance. Such sequencing is also important to assess the possible origin of the case or outbreak.

Industrial farming is big business and it is influential with agencies whose task it is to promote agriculture. Here’s the (expected) take of the World Organisation for Animal Health: “Recent identification of the virus in different animal species is no additional cause for alarm”:

So far, no evidence has suggested that animals play any particular role in the epidemiology or the spread of the pandemic H1N1 2009 virus among humans. Instead, investigations led by competent national authorities point to possible human-to-animal transmission in most cases. For this reason, the OIE considers that it is sufficient to certify the healthy state of animals for international trade during the relevant period before their exportation and maintains its position that no specific measures, including laboratory tests, are required for international trade in live pigs and other susceptible animal species and/or their products. (World Organisation for Animal Health)

You can’t get much more explicit than that. In fairness it’s followed by recommendations for continued vigilance. Unfortunately it appears as an after thought. The main message is: move along, nothing to see here.

But I can’t stop myself from gawking.

Comments

  1. #1 Danforth
    November 6, 2009

    Can they tell whether the cats are being infected with the vaccine or the ‘wild’ virus, (whatever that means these days), and will they tell us if they can?

    And which possibility do you think is worse?

    http://wp.me/pr6De-Cg

    “The influenza virus has an interesting and chameleonlike evolutionary history. We should not contribute to the dangerous reassortment of the virus’s genes, which occurs in nature all the time, by engaging in certain agricultural practices without proper precautions. Nor should we try to combat influenza by developing live recombinant influenza vaccines that might prove lethal to other species.”
    Christoph Scholtissek, Virologist at the University of Giessen’s Institute for Virology, Germany – Natural History 1/92

  2. #2 revere
    November 6, 2009

    Danforth: There is no vaccine involved here. The cat was not exposed to the vaccine, live or inactivated, or anyone who got a live virus vaccine. But, yes, you can tell the difference. The live virus vaccine is cold attenuated. And all influenza viruses are “recombinations” naturally. I assume, then, you are opposed to any live virus vaccine for any disease?

  3. #3 Danforth
    November 6, 2009

    If they must be used, I think they should only use them in humans and companion animals. But I see a pattern over years since Scholtissek made his warning of diseases, particulary influenza jumping species barriers after an MLV vaccine is used in the originating species. There’s equine flu and strep jumping to dogs. Now the swine flu – they were experimenting with MLV vaccines in pigs here before that one jumped. (Though there is a theory about an improperly killed vaccine, too, on that one.)

    That’s why I’m wondering about the timing in the cat infection.

    Are you sure they did the epidemiology already and/or the virus typing to be positive?

  4. #4 abc
    November 6, 2009

    The AVMA has already requested that the CDC make veterinarians (and people in the swine industry) a priority group for receiving the vaccine. I wonder if this will hasten things along at all.

    They’ve also made preliminary recommendations regarding the cat case–but there just isn’t much information available yet. Quite a fortunate accident that it was discovered at all.

  5. #5 Danforth
    November 6, 2009

    A comment by jack on the NYT blog linked to this document. I’m certainly no virologist, but I understand that just the HA and NA genes of the pandemic virus are preserved in the vaccine strain. So since they are matching a matrix protein, then I think I’ve proved to myself that the cat did NOT get infected by the vaccine virus.

    http://www.usda.gov/documents/FINAL_RESULTS_2009_PANDEMIC_H1N1_INFLUENZA_CHT.pdf

  6. #6 Cate
    November 6, 2009

    What is the efficacy rate difference is for live-nasal vs. inactivated intramuscular HiN1 vaccine? Sorry if this info was recently posted — grant writing, so off-line for a while.

  7. #7 Cate
    November 6, 2009

    Yes, yes, yes — a typo. Sorry.

  8. #8 Anty
    November 7, 2009

    In Norway the food inspection finds more and more pigfarms infected. Status nov. 6 was 38 pig farms infected so far. I dont think this is just happening all over Norway!
    Link (to food inspection, in norwegian)
    http://mattilsynet.no/smittevern_og_bekjempelse/dyr/b-sjukdommer/svineinfluensa/hendelser/38_besetninger_smittet_med_svineinfluensa_74276

  9. #9 Hank Roberts
    November 7, 2009

    http://www.sciencenews.org/view/generic/id/49323/title/H1N1_Call_to_revise_flu-mask_policy

    H1N1: Call to revise flu-mask policy
    By Janet Raloff, Friday, November 6th, 2009

    Three groups of healthcare professionals sent a letter to President Obama yesterday …. What these groups want: formal recognition that two studies last month showed conventional surgical masks are about as protective as the fancy — but much more expensive — N95 respirators in limiting H1N1 infection.

    Cat A: “Who was that masked man, anyway?”
    Cat B: “Who _cares_ as long as we get fed?”

  10. #10 phytosleuth
    November 7, 2009

    Um…letting your pet lick your plate? Gee. You think?

  11. #11 phytosleuth
    November 7, 2009

    Hmm. Does dog food and cat food contain lung by-products from pigs, horses, poultry? How about human food?

  12. #12 Karen
    November 8, 2009

    Is anyone looking for H1N1 in dogs yet? The report about the cat wasn’t a big surprise here. I was pretty certain that our cats came down with it just after the humans in the family got sick, but our dogs were also “off” in the same time frame. They were less lethargic than the cats and humans in the house, but to my experienced eye, they weren’t right either. None of the critters was sick enough that I felt the need to take temps, though I probably should have just to have the data.

  13. #13 red rabbit
    November 8, 2009

    I’ve been hearing about outbreaks locally on turkey farms. What worries me is my husband works at a youth treatment centre/farm (a la Neon Rider) which keeps both pigs and turkeys, along with the kids.

    Sounds like a pandemic breeding ground to me.

  14. #14 Jonathon Singleton
    November 9, 2009

    Thank you very much Revere for this posting.

    I agree with Effect Measure, the World Organisation for Animal Health are being somewhat epidemiologically glib and shortsighted in their, as you say, “move along, don’t focus too much on this issue” attitude…

    Bloody odd behavior of the WHO, if you ask me!

  15. #15 Jonathon Singleton
    November 9, 2009

    Oooops Revere, I was rushing earlier, the final sentence should read: “Also, bloody odd behavior from the WHO, if you ask me!”