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Effect Measure

Effect Measure is a forum for progressive public health discussion and argument as well as a source of public health information from around the web that interests the Editor(s)

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The Editors of Effect Measure are senior public health scientists and practitioners. Paul Revere was a member of the first local Board of Health in the United States (Boston, 1799). The Editors sign their posts "Revere" to recognize the public service of a professional forerunner better known for other things.

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biology:

The complexity of the spread of flu virus

Seasonal flu is a multicolored tapestry.

Antibodies from survivors of 1918 era pandemic

Fascinating paper on harvesting antibodies produced by a 90 year old pandemic.

More about the adapting bird flu viruses

Both more and less than meets the eye.

Naming a bird flu virus

Politically correct terminology.

Important new flu paper in Cell: part III

Oxidative stress, SARS and H5N1

Important new flu paper in Cell: part II

Paying the Toll-like receptor.

Important new flu paper in Cell: part I

For Whom the Toll receives.

Vagrant birds and bird flu

Wrong-way Corrigan's of the bird world and bird flu

Dead ducks, live ducks and bird flu [updated]

Not all ducks are the same when it comes to bird flu.

What's up with H5N1 in civets in Vietnam?

How and why did Owlston's palm civets get bird flu?

Good bird flu primer

Short video with bird flu basics.

Bird flu, mosquitoes and blowflies

A notice from ProMed yesterday alerted many of us to a new published report [subscription firewall] about H5N1 influenza detection in an arthropod species in the vicinity of an infected poultry farm. The arthropods were mosquitoes (Culex tritaeniorhynchus) in Thailand....

Virus preference for humans and birds in the 1918 virus

The long and the short of the glycan hypothesis.

Bird flu and arsenic

Is there an interaction between this toxic metal and the bird flu infection?

Tamiflu resistance in seasonal flu: the devil is in the details

No surprise. It's more complicated than we might think.

The clinical bird flu picture so far as reviewed in the New England Journal

Who dies and of what?

Does H5N1 spread from cats to dogs and vice versa?

Dogs and cats can be infected with H5N1. Can they infect each other?

Bird flu, umbrellas and cones

A new paper on what makes an flu virus prefer one host or cell over another.

Pandemic influenza subtypes: end of the year musings

Influenza pandemics happen. But which subtype will it be?

Now I'm the one complaining about WHO (again)

Wherein I give the WHO spokesperson a biology lesson.

The mutated influenza pig virus story

On the swine influenza H2N3 reassortant paper in PNAS.

Birds, bird flu, bird brains and scientists behaving badly

A Nature Commentary that makes sense and is a Call to Action. Again.

Genetically fit oseltamivir resistant H5N1 mutants

Genetically fit Tamiflu resistant strains exist. Too bad.

How is a dog like a bird?

If you've heard of the disease distemper it may be because you had to get your dog vaccinated against it. Dog or canine distemper is caused by a measles-like virus, Canine Distemper Virus, but it doesn't just affect dogs. It...

Flu biology: receptors, II

Bird flu receptors all over the human body. Hmmm.

Flu biology: receptors, I

Where in our bodies are the receptors for bird flu virus? Part I.

A flu virus protein that promotes secondary bacterial infection

The PB1-F2 protein. Interesting.

H5N1 infection in sparrows, starlings and pigeons

Research team starts to characterize susceptibility in small land based birds.

Paper on mutation that enhances infection of upper airways

Mutation E627K in PB2 affects ability of H5N2 to infect upper airways in mice

The Super Sentinel Chicken

Turning a chicken into a canary.

Flying blind into the cytokine storm

Know what you are doing before you do it.

Figuring out how flu gets around

The problem of how flu "gets around" is still a problem.

Cytokine storm revisited

An interesting experiment. But does it mean what it is being taken to mean?

How long do we shed flu virus?

It seems we shed virus longer than we thought.

Mild bird flu: no news is bad news

Where are the "missing" bird flu cases?

Not All in our Genes, The Sequel

Is the apparent clustering of bird flu cases in blood relatives only apparent?

Do veterinarians catch influenza from their patients?

Apparently they do.

To every flu there is a season. But why?

Why is flu "seasonal"?

Flu in the kitchen store

What my book fetish has to do with cell surface receptors.

A paper on cytokine storm

What's the mechanism of this deadly immune system overreaction?

Transmissibility in the 1918 flu virus

Two small change turn a non-transmissible (but virulent) flu virus into a highly transmissible one.

Letting the H5N1 cat out of the bag

Asymptomatic cats infected with H5N1 in Austria.

Tamiflu resistance: digging under the headline

Sometimes it sounds like spin but isn't.

Infecting monkeys with 1918 pandemic flu virus

What can we learn from this potentially dangerous experiment?

Pigeons and cats. New ecological niche for H5N1?

More reports of H5N1 in pigeons and cats. Is this a possible endemic reservoir for cities?

Another H5N1 paper that tells us what we thought we knew was wrong

H5N1 can infect the upper respiratory tract. What does this mean?

H3 and H1 evolution

The "normal" flu virus is pretty mysterious, too.

Where to sample birds and some more stuff

Virus more prevalent in the upper airway than feces of birds.

Structure of influenza NP protein determined

Nucleoprotein (NP) is needed for the influenza virus to replicate. We now know what it looks like and it is interesting.

Another "big" H5N1 science paper

New Nature paper. Old story.

How does flu spread?

If you know, tell me.

New paper on H5N1 virulence gene

Some new and interesting information on how H5N1 became more virulent to chickens.

Bird flu virulence: come what may

Scientists admit they don't have a clue how bad bird flu could be.

Not all in our genes

Unraveling genetic factors and bird flu.

Influenza virus, science background IV

Conclusion of the series on influenza surface proteins

Sparrows, new strain: bad news?

H5N1 is in sparrows and a new prevalent strain has been found in poultry in China.

Influenza virus, science background, III

MOre on viral receptors in influenza.

Influenza virus, science background, II

Some terminology for understanding influenza virus receptors.

Influenza virus, science background, I.

Updated post from the archives on influenza science. First of four.

Another "breakthrough" story on preventing flu

Using Defective Interfering viruses as an autovaccine for flu. Not so fast.

A cautionary tale about cytokine storm

How a drug to treat an overactive immune system went wrong.

The Nature paper on the 1918 virus and immune reaction

The 1918 influenza virus induces pro-inflammatory and cell death responses in mice.

Must H5N1 moderate its virulence as it evolves?

On the surprising evolutionary dynamics of virulence.

Wanted: leadership in public health

Flu sequence sharing. Leadership still needed.

Important new initiative on sequences

Scientists agree to a new sequence sharing collaboration.

CDC unfreezes US flu isolates

CDC thaws out some flu sequences

Increasing genetic diversity in H5N1

Changes in the virus suggest we need to adjust vaccine strategy.