Its been years ago, now, that I nomie-nomed up Behes stupid arguments about TEH EDGE UV EVILUTION and HIV-1. Geeze, what, two years ago? And to this day there are still things about Behe that make me literally *LOL*
For instance, Ive always loved Behes IDiotic perspective on viruses. You see, bacteria and humans and such contain elegantly Intelligently Designed molecular machines that are absolutely perfect. Viruses, on the other hand, are common hooligans that just ‘gum things up’:
Like throwing a wad of chewing gum into a finely tuned machine, its relatively easy to clog a system, blah blah, *fart*
Instead of appreciating viruses for the stealth, immensely clever (and in the case of HIV-1, unstoppable) creatures they are, Behe sees them as lumbering dimwits hurling rocks and his pretty, pretty machines.
Yeah, turns out a potential HIV-1 therapy someone has come up with is to just throw shit at Vpu to gum it up:
We propose that it is feasible to increase the effective cell surface density of Vpu-free tetherin by designing transmembrane peptide decoys that target the Vpu TM α-helix and abort the assembly of tetherin-Vpu heterooligomers.
It requires exploring the TM sequence landscape to identify optimal Vpu TM matchmakers that would self-assemble into unproductive heterooligomers, thereby overcoming the restrain on tetherin and the consequent restriction of virion release from infected cells.
In other words, find any peptide that binds to Vpu in such a way it forms non-functional heterooligomers instead of binding up tetherin. Dump it into HIV-1 patients. Essentially ‘knock down‘ Vpu. PROFIT!
Throwing gum in the works! So unrefined! *puts noes in air*