(this post is me laughing at Sternberg, intermittently talking about ERVs, ask Qs if Im not clear– sorry, laughing so hard, must share this joke as well as I can between snorts)
RICHARD STERNBERG IS SO STUPID!
Arrogant, stupid little twat that doesnt even know what he doesnt know.
*wipes away tears*
I was just listening to the ‘debate’ between Shermer/Prothero and Meyer/Sternberg.
Prothero brought up ERVs, and how they are leftover garbage cluttering up your genome.
Sternberg was all like, “NUH UH! IZ SO HAS FUNKSHUN!!” Its at about 1 hour, 28 min.
Sternberg tries to say that there are lots of ‘ERVs’ around during embryological development, therefore, PURPOSE AND JESUS!
Early in development, your epigenetic slate is wiped clean. That means that any endogenous retroviral protein that retains the ability to code protein that was held in check by epigenetics, is now free to… roam. And they are going to. LTRs are very powerful promoters.
This is a very bad thing.
When youve got reverse transcriptase going, plopping shit it where it aint supposed to go, making shit you arent supposed to make, bad things happen. We think that a large contributor to the vast number of spontaneous abortions/miscarriages is this DNA damage, but as Ive said a million times, epigenetics research is young. Another avenue to explore in the future. *shrug*
Anyway, thats why ‘ERVs’ are present during development.
But even if these mistakes do cause trouble, are they, overall, useful like Sternberg implies?
Well, a handful of endogenous retroviral proteins (not endogenous retroviruses) have been domesticated by the host genome. Thats been in the Index of Creationist Claims About ERVs for years.
But this ‘explosion’ of ‘ERVs’ is in no way necessary. We know this, and weve known it for ABOUT 20 YEARS NOW.
Okay, follow me here–this is where I fail to believe Sternberg is any form of biologist– He says “If you knock out these sequences… if you block their expression…”
Those are two completely different things. ‘Knocking out’ implies genetic manipulation that physically removes any and every ERV sequence from the mouse genome. No one has done that. No one did that ‘in 2005’, including ‘Shapiro’, whoever the fuck that is.
Blocking ERV expression, on the other hand, is relatively trivial– Weve got a multitude of antiretroviral drugs that weve been using on HIV-1 for decades. Anti-HIV drugs work on any other retrovirus too, including ‘active’ ERVs. So what happens if you give mice antiretrovirals when theyre pregnant?
Well, that research might have been done in 2005, as Sternberg suggests. But I know it was already done IN 1992 (heres one everyone can read from 1993). Because we wanted to know what would happen to HIV-1(+) pregnant mothers on antiretrovirals. We didnt want a generation of thalidomide kids in Africa.
The reason why mouse embryos arrest in development in the presence of antiretrovials like AZT is because of the drugs cytotoxic side-effect profiles. AZT, for instance, is toxic to mitochondria, which everyone who knows shit about antiretrovirals knows. Hey, lets look at Wikipedia! OH LOOK, ITS IN WIKIPEDIA! Fully grown people can ‘handle’ the stress of antiretrovirals (like AZT) better than embryos, but even some embryos can tolerate the cytotoxic stress of antiretrovirals (as that 1993 research shows). And we know in 2009 that children born to women taking antiretrovirals are fine.
The effects of AZT on embryos has shit to do with ‘getting rid of ERVs’.
Sternberg knows jack shit about ERVs and embryological development.
Sternberg is not stupid because he didnt know this information. Hes stupid because he stood up on a stage and lectured bout stuff he doesnt know anything about.
But thats not just stupid. Thats IDiot!