What is it about ERVs that makes kooks cling desperately to them, like little ‘gag-pol-env’ life-rafts, as the kooks FAILboats sink into even further obscurity?
I think the general populations ignorance about ERVs is what kooks find so attractive. Kooks, like Creationists, can say any damn thing they want about ERVs, and Average Joe/Jane doesnt know any better. Some Creationists might be ignorant themselves and actually believe such claims, but Ive corrected Creationists so many times at this point, its frankly hard to believe Creationist Claims about ERVs are anything but purposeful, malicious lying and manipulation.
Same goes for HIV Deniers.
Years ago, when HIV Denier Rebecca Culshaw had a job (HIIIIIII BLONDIE!!!! **WAVES**), she tried to pull the ‘HIV IZ ERVS!‘ card. You see, HIV-1 is supposedly a retrovirus, and there are endogenous retroviruses in your DNA, therefore, HIV is a lie.
That is fantastically stupid on so many levels.
2– Lentiviruses look nothing like the ERVs in your genome, genetically or structurally. The retroviruses in your genome have been extinct for thousands–>millions of years. HIV is to the youngest ERVs, as Humans are to blue-green algae. Confusing the two is stupid.
3– Even pretending there is a lentivirus ERV, ‘lentivirus’ is genus. Each species of lentivirus has its own distinctive features– equine infectious anemia virus has tat, rev, and S2. FIV has vif and rev. BIV has tat, vif, and rev. HIV-1 has vif, vpr, vpu, tat, rev, and nef. HIV-2 has vif, vpr, vpx, tat, rev, and nef. I have no idea what caprine arthritis encephalitis virus looks like, BUT, the point is, there is a ton of gross genetic diversity in lentiviruses. Not just the actual sequences, but the actual GENES, the sizes of those genes, the way the mRNA is processed, the way the proteins are processed. Even if there were lentiviral ERVs, we would be able to differentiate between an endogenous sequence and a novel lentiviral infectious agent like HIV-1.
4– Even pretending there is a lentivirus ERV. Even pretending there is a lentivirus ERV that is identical to HIV-1. That does not mean HIV-1 wouldnt be an infectious agent! Mice have endogenous MMTVs. They can also be infected with exogenous MMTVs. Endogenizing a retrovirus doesnt mean you are immune from all members of a genus of retroviruses. Endogeniation isnt immunity. Sometimes its actually detrimental to immunity from related families of retroviruses. Ugh.
Why do I bring up HIV Deniers and ERVs again now?
Why is it so hard to isolate and purify human immunodeficiency virus (HIV)?
Its not. Its amazingly trivial, thanks to 25 years of reagent and protocol development. Im inventing something to make it even more trivial (technically, its to purify and concentrate pseudoviruses, which are a pain in the ass, but it could be used for regular HIV-1 viruses too).
Why has no one been able to see, by electron microscopy, a single HIV particle in the blood of AIDS patients, even those who have a “high viral load”?
Why does HIV seem to mutate with startling rapidity?
It doesnt ‘seem’ to mutate. It actually mutates via an error-prone reverse transcriptase and recombination. This is very trivial shit, here.
AIDS researchers have not been able to come up with answers to these questions.
Well, Im not an AIDS researcher, Im an HIV-1 researcher, but Im pretty sure I just ‘came up with’ answers anyone who gave a rats ass could find via TEH GOOGLE MACHINE.
HERVs–human endogenous retroviruses–might provide explanations that have been overlooked for 20 years, writes Professor Etienne de Harven, M.D., in the fall 2010 issue of the Journal of American Physicians and Surgeons. HERVs are present in all of us, and fragments of their DNA may be confused with HIV in the polymerase chain reaction (PCR) tests used to estimate viral load.
I have dozens of HIV-1 primers. I have never gotten a positive mock (uninfected cells) ever. HIV-1 looks like nothing in your genome.
About 8 percent of the human genome consists of sequences incorporated from retroviruses. When cells break down, DNA fragments are released into the circulation–including these viral sequences. Patients with clinical AIDS carry a large spectrum of infectious diseases, so a high level of circulating DNA is expected.
Infected cells die via apoptosis. Free-floating DNA should NOT be present. Free-floating DNA is a sign of NECROSIS. Last I heard, HIV/AIDS patients die from complications due to secondary infections, not because their lungs/legs/stomach/hearts/brains were rotting. Christ this is basic fucking biology, man.
Alternate hypotheses need to be objectively assessed, and conclusions must be based on scientific evidence rather than consensus.
Then you better get back to the drawing board, Professor Etienne de Harven, M.D, because your ‘alternate hypotheses’ are based on your ignorance and stupidity, not science.
There is an actual ‘article’ attached to this press release. It looks as if it were written when I was in kindergarten. Science has moved forward– this mans brain has been frozen in time for 20 years. Reminds me of someone else…