Not XMRV in African blood donors or HIV/AIDS patients.
Absence of detectable xenotropic murine leukemia virus-related virus in plasma or peripheral blood mononuclear cells of human immunodeficiency virus Type 1-infected blood donors or individuals in Africa.
This is the third study not to find XMRV in HIV/AIDS patients. HIV/AIDS patients have every other pathogen under the sun at higher rates than healthy people. Except XMRV? Uh huh. Right. There is simply not enough evidence to believe XMRV is a real human pathogen, much less that it is the causative agent in a given disease, even less so with this apparent lack-of-connection on top of it.
‘Certain groups of people’ clinging to XMRV–>anything are explaining this lack-of-connection by arguing that it is possible HIV-1 infection actually prevents XMRV infection, and thats why XMRV isnt found in HIV/AIDS patients.
Yes, that is possible.
But then again, anything is possible if you have no idea what you are talking about, youre just making shit up, and you are arrogant enough to think your GoogleU degree means something*.
What these ‘certain people’ are confused about is something called superinfection.
Superinfection is when one cell is infected with two different viruses. As in, HIV-1 Subtype B and HIV-1 Subtype C, or HIV-1 Subtype A and HIV-2. One person who was independently infected with HIV twice, and then has any number of cells also infected twice.
This ‘normally’ doesnt happen, because HIV-1 pisses on the fire hydrant. When a cell is infected with HIV-1, various HIV-1 proteins will downregulate the HIV-1 receptor (CD4) on the infected cell. Its HIV-1s way of saying ‘THIS IS MY FORT! NO ONE ELSE ALLOWED! MINE!!!!’
If someone already has a well established HIV-1 infection, cellular targets of HIV-1 infection are either a) dead or b) already infected, so it becomes more difficult for a different kind of HIV-1 to gain a foothold and infect that person a second time with an alternative genotype of HIV-1.
Thats not to say that it is impossible. Yes, we have HIV-1 ‘Subtypes’, but those I think will ultimately disappear. Thats because people can get infected with two different subtypes, and then you inevitably get superinfection, and then we have viral sexy time, and then we get babby viruses that are part one thing, part another: circulating recombinant forms. No more subtypes.
Guards against superinfection (pissing on the fire hydrant) come from the viruses themselves, like downregulating receptor. HIV-1 uses CD4 and CCR5/CXCR4. XMRV uses XPR1. There is no scientific evidence that infection with one virus impacts infection of another. Nothing. Nor has any putative connection been proposed by anyone, anywhere.
That is, ‘anywhere’ except message boards, and ‘anyone’ except random people on the internet finding an article above their heads on ‘superinfection’ that they dont understand, but are too uneducated to realize they dont understand, and too arrogant to ask for help.
* NOTE: Asking questions like “Can HIV-1 infection inhibit XMRV infection?” is not stupid. Aggressively asserting that “HIV-1 infection inhibits XMRV infection” while ridiculing scientists for ‘wasting time looking’ for XMRV in HIV-1(+) patients is stupid.