Search Results for adenovirus

Some of you might remember the waves made earlier this year about ‘The Immunity Project’. They were crowdsourcing an HIV vaccine that was magical and amazing and they were totally going to give it away for free!! YAY! … Except ‘The Immunity Project’ basically had nothing to back their claims up. No publications, the investigators had…

You all might have heard about ‘delta32′ or ‘delta-CCR5′ people in association with HIV infection. People who naturally, by chance, have deletions and mutations in the CCR5 gene of their DNA dont make functional CCR5 proteins. It doesnt appear to be ‘a big deal’, and people who have this particular mutation seem to live normal…

This idea… this idea might be absolute genius… Immunogenicity of bivalent human papillomavirus DNA vaccine using human endogenous retrovirus envelope-coated baculoviral vectors in mice and pigs. The ‘best’ vaccines are live attenuated vaccines.  Weakened/Misadapted viruses that can replicate a little bit, and get your immune system to generate a B-cell response (what you get with…

BWAHAHAHAHA GMO virus to replace pacemakers

Im seriously, you guys. ANY MEDICAL CONDITION YOU CAN THINK OF: There is a scientist, somewhere, trying to use viruses to treat/cure that condition. The latest: Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18 Lots of people, either through age or genetic defect, need pacemakers. Pacemakers, while functional, come with a…

NICE! Gene therapy of pancreatic cancer targeting the K-Ras oncogene Cancer sucks, but some kinds of cancers suck worse than others.  One that really sucks is pancreatic cancer.  From the intro of this paper: Pancreatic cancer (PC) is the fourth leading cause of cancer death among men and women, comprising 6% of all cancer-related death.…

Gene therapy for Hemophilia A

So what do you do after you use a genetically modified virus to treat–>functionally cure Hemophilia B? Why, use a genetically modified virus to treat–>hopefully functionally cure Hemophilia A, of course! Generation of an optimized lentiviral vector encoding a high-expression factor VIII transgene for gene therapy of hemophilia A Though they are both ‘hemophilia’, hemophilia…

Look, scientists are nuts.  Virologists, on the other hand, are certifiably insane.  As Hedwig would say, virologists make the strangest things seem suddenly routine.  Yesterdays absurd future technology (GENE THERAPY!) is now something as miraculous as curing genetic diseases, and as mundane as an anti-smoking therapy. Todays insane idea? Using mouse and rat parvoviruses to…

Ive written about noroviruses a few times on ERV.  Theyre insidious little bugs that hide on door handles and food utensils (… and food…) and if you ingest them, you poop.  A lot.  Like I have said before, any time you hear about a ton of people getting sick on a cruise ship, you can…

Epic disaster in HIV vaccine world

I can think of at least two ‘worst nightmares’ for vaccine designers. Your vaccine looked super in animal models and such… but it turns out to be directly harmful to people.  And not ‘some’ people.  All people. Your vaccine actually does the opposite of what you want it to do– instead of preventing the disease,…

Gene therapy for Hemophilia B

For the millionth time– Viruses are not just pathogens that make us sick. In the modern world, viruses have been domesticated, and are now used to treat/cure diseases. Example #gazillion: Hemophilia B: Adenovirus-Associated Virus Vector-Mediated Gene Transfer in Hemophilia B This study is far from perfect, and of course very preliminary, but still very exciting.…