Search Results for sclerosis

Okay, I have written a LOT about the connection between wayward ERV activity and Multiple Sclerosis. This is something scientists have been investigating for a long time… but we still do not know exactly what is going on. It seems the running hypothesis is that ‘something’/’somethings’ alter the epigenetic profile of individuals DNA, allowing for…

I have written quite a bit about the connection between wayward expression of an ERV, and Multiple Sclerosis. ERVs and Multiple Sclerosis ERVs and Multiple Sclerosis, #2 ERVs and Multiple Sclerosis, #3 ERVs and Multiple Sclerosis, #4 ERVs and Multiple Sclerosis, #5 I am very comfortable saying there is a connection between ERV expression and MS.…

ERVs and Multiple Sclerosis, #5

This is not overly helpful information for MS patients, but its still good news: No additional copies of HERV-Fc1 in the germ line of multiple sclerosis patients. Previous research has indicated that there are endogenous retroviruses that are disregulated and leading to detectable production of ERV proteins in MS patients.  They found the bugger involved–…

ERVs and Multiple Sclerosis, #4

I wasnt super thrilled about the last ERV–>MS paper I wrote about, but I really like this new one: Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease. Those of you who have been following the XMRV fiasco will find this intro paragraph very interesting:…

ERVs and Multiple Sclerosis, #3

ERVs and Multiple Sclerosis ERVs and Multiple Sclerosis, #2 Hmmm… This new paper on the association between ‘active’ ERVs and Multiple Sclerosis is a step back, and a step forward, at the same time: Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active Multiple Sclerosis. If you go back and read…

ERVs and Multiple Sclerosis, #2

The connection between wayward endogenous retroviral protein production and multiple sclerosis is tightening Sure its still a mess, sure we dont have all the pieces to The Puzzle– but weve got a strong foothold now. We know we are going in the right direction. A subtle paper just came out in ‘Journal of Virological Methods’.…

ERVs and Multiple Sclerosis

While Ive mentioned the connection between endogenous retroviruses and Multiple Sclerosis on teh blag before, I realized Ive never written a post on this topic. Fortunately I just read an interesting paper thats provided me with a good opportunity to do just that: Analysis of transcribed human endogenous retrovirus W env loci clarifies the origin…

ERMAHGERD! IM GONNA TALK ABOUT ERVS ALL WEEK!!! I have a love/hate relationship with the ERV-[insert brain/CNS disorder] ‘connection’.  Labs from all over the world, with independent protocols and patient cohorts, see there is something going on with, for example, ERVs and multiple sclerosis.  So there is *something* going on there, we just arent sure…

If you are reading this blog, you already know all about how a huge portion of your genome is parasitic junk DNA (~40-45%), a fraction of which is retroviral junk (ERVs, ~9%).  If youre new here… SURPRISE! Sure, we have a gene here, a promoter there (maybe) that was domesticated for human genome use, but…

HERVs and disease and junk DNA

I love junk DNA. Well, thats an understatement– I mean I love is SO MUCH I created a blog dedicated to a particular form of junk DNA, endogenous retroviruses. I love how we can learn fantastic things about organisms (and their diseases) from, basically, dumpster-diving though millions and millions of years of mistakes and accidents…