ERVs

Category archives for ERVs

This idea… this idea might be absolute genius… Immunogenicity of bivalent human papillomavirus DNA vaccine using human endogenous retrovirus envelope-coated baculoviral vectors in mice and pigs. The ‘best’ vaccines are live attenuated vaccines.  Weakened/Misadapted viruses that can replicate a little bit, and get your immune system to generate a B-cell response (what you get with…

ERMAHGERD! ERVALANCH! ERVs and Placentas

The connection between ERVs and placentas is already well established. Without a shadow of a doubt, the ability of mammals to generate placentas was, in part, accomplished by domesticating an endogenous retroviral env protein.  In humans, we call this protein syncytin, or ERVWE1. This new paper in Nature Genetics takes the ERV-Placenta connection a step…

Here is a nice open access review article on ERVs and their association with cancer: Human endogenous retroviruses and cancer prevention: evidence and prospects While thats wonderfully interesting, what I want to focus on is a bit at the end. More information I have never heard before– An amino acid sequence similar to HERV-K-MEL, recognized…

ERMAHGERD! ERVALANCH! ERVs and melanoma

I was actually unaware of this– But melanoma is Yet Another Disease that has been associated with wayward ERV transcription and translation.  Scientists have found inappropriate ERV RNA, protein, and anti-ERV antibodies in melanoma patients. This is the first paper to break down ‘melanoma’ into subtypes (like ‘cancer’ is not monolithic, all ‘melanomas’ are not…

ERMAHGERD! IM GONNA TALK ABOUT ERVS ALL WEEK!!! I have a love/hate relationship with the ERV-[insert brain/CNS disorder] ‘connection’.  Labs from all over the world, with independent protocols and patient cohorts, see there is something going on with, for example, ERVs and multiple sclerosis.  So there is *something* going on there, we just arent sure…

ERV on Skeptiles!

I recently got to chat with the guys of Skeptiles this weekend about viruses, vaccines/anti-vaxers, HIV, HepC, Creationists– We were all over the place, and it was so much fun! Skeptiles: Episode 21 – Abbie Smith

CERVs! Crocodile ERVs (not chimpanzee!)

Uh oh. VIRAL NOMENCLATURE WAR!!! CERV vs CERV!!! Chimpanzee vs Crocodile!!! Its gonna be a THROWDOWN!!! … Or we can just read a neat open-access article about ERVs in crocodiles Strong purifying selection in endogenous retroviruses in the saltwater crocodile (Crocodylus porosus) in the Northern Territory of Australia Specifically, Crocodylus porosu, saltwater crocodiles, one of…

PIGS! PERVS!!

We now have the complete pig (aka Sus scrofa) genome!  You know what that means……….!!! PERVs!!!! Analyses of pig genomes provide insight into porcine demography and evolution While I am a huge fan of all ERVs, including PERVs, PERVs hold a special place in my heart. Literally. Physicians can use pig parts and organs for…

HIVs controlled by HERVs

Technically, its the immune response to the HERVs that can control the HIVs, not the HERVs directly. Ive written about the proposed connection between ERVs and HIV a couple times before– Briefly, viruses do lots of things by accident.  Things just happen.  Sometimes viruses make us blind for no good reason, or give us cancer…

ERVs and Multiple Sclerosis, #5

This is not overly helpful information for MS patients, but its still good news: No additional copies of HERV-Fc1 in the germ line of multiple sclerosis patients. Previous research has indicated that there are endogenous retroviruses that are disregulated and leading to detectable production of ERV proteins in MS patients.  They found the bugger involved–…