HIV/AIDS

Category archives for HIV/AIDS

New, weird, out-of-left-field, ideas– we need them to stop HIV. This one makes sense, in retrospect, but I wouldnt have thought to try what these folks did: Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection Background info: HIV loves to rip through CD4+ T-cells in gut-associated…

For some reason, pop news became enamored with this paper last month (unfortunately while I was away at a conference): HIV infection en route to endogenization: two cases Inexplicable media frenzy– Scientists find mechanism for spontaneous HIV cure French scientists find genetic mechanism by which two men were spontaneously cured of HIV. HIV discovery offers…

I write about lots of things on ERV, but I didnt anticipate ever getting to the point where I can write new blog posts on new publications by cutting and pasting from old blog posts on old papers… Lots of news outlets have been talking about this new paper: Impact of HLA-driven HIV adaptation on virulence in…

Why do scientists always forget about luck?

You get the data when you get the data, but the information we get from this study would have been useful several years ago: Persistence of Virus Reservoirs in ART-Treated SHIV-Infected Rhesus Macaques after Autologous Hematopoietic Stem Cell Transplant The Berlin Patient– Guy gets HIV, develops a blood cancer, gets radiation and chemo for the cancer,…

ERVs vs HIV– Maybe a bad idea

For quite a while, now, there has been a connection between Endogenous Retroviruses and HIV. For some unknown reason, some of the young ERVs in humans, the ones that can still code for a protein here and there, are reactivated in HIV+ patients. Scientists have found ERV RNA in HIV+ patient plasma, and they have…

This is not, in any way, a ‘clean’ blog. But I cannot type my genuine reaction to this news: Shift of HIV Tropism in Stem-Cell Transplantation with CCR5 Delta32 Mutation I have not stopped cussing since I heard about this. God dammit, HIV. God DAMMIT. We had ONE THING. ONE THING that WORKED to CURE…

Ive written about modifying plants to do lots of fun things (vaccines, counter allergies, etc) in the past: Green our vaccines! Green our vaccines! Part II Green our vaccines! Part III Green our vaccines! Part IV Unfortunately, this kind of technology has been held back by luddite/anti-biotechnology pressure from the general public. It has *not* moved forward…

“HIV mutates a lot”. People ‘get’ that. Why is HIV hard to stop? Why is HIV hard to treat? “HIV mutates a lot”. But HIV does not mutate willy-nilly. It mutates at an evolutionarily defined rate. The reverse transcriptase enzyme makes mistakes during replication that are beneficial to HIV– creating a diverse population, a quasispecies,…

Some of you might remember the waves made earlier this year about ‘The Immunity Project’. They were crowdsourcing an HIV vaccine that was magical and amazing and they were totally going to give it away for free!! YAY! … Except ‘The Immunity Project’ basically had nothing to back their claims up. No publications, the investigators had…

c0nc0rdance + HIV vs Creationists

Though ERVs are my favorite tool vs Creationists, HIV is a fantastic choice as well. I mean, has anyone seen hide or hair of Behe since 2007? Poor guy. Alas, there are still Creationists out there, so to address some of their ‘concerns’, c0nc0rdance made a couple of vids using his favorite HIV protein, Vpr: