Search Results for vpu

HIV-1 Vaccine: Again, OH SHI-

Your immune system is like an onion ogre parfait. Its has lots and lots of layers. You have intrensic immunity– Abilities every single one of your cells has to defend itself from viruses. VpuTetherin would be a good example of this, as would APOBEC and Trim5a. Pick a cell in your body– it can make…

LINEs dont do RT like ERVs, HIV, or HBV!

The only creatures that existed in the RNA World that still exist today, are viruses. They are the only creatures that still use RNA to store their genome– they never upgraded to V2.0, DNA. In fact the creatures that might have written V2.0, retroviruses, are still around today too. They carry their genomes as RNA,…

X-linked adrenoleukodystrophy (X-linked ALD) is a demyelination disease in little boys. The kids are usually dead before they hit adolescence. The demyelination mechanism is not the same as the demyelination disease you all have heard of, MS. With X-linked ALD, the kids dont have a functional ABCD1 gene. This means they cant break down very-long-chain…

Nef: Savior and Satan

Vpu has kinda been my accessory protein of choice here at ERV, but its not the only one with a super cool evolutionary history and super cool evolutionary implications. Another particularly fun one is Nef. This eeeeeeeety bitty HIV-1 protein (27 kDa) has a lot on its plate. Contrary to the ‘expert’ opinion of Michel…

While we are on the topic of IDiot Michael Behe, I thought now would be a good time to check in on our dear friend, HIV-1 Vpu! What neat evolutionary tales do you have for us this week, HIV-1 Vpu? Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent…

Haha! Gumming up the works!

Its been years ago, now, that I nomie-nomed up Behes stupid arguments about TEH EDGE UV EVILUTION and HIV-1. Geeze, what, two years ago? And to this day there are still things about Behe that make me literally *LOL* For instance, Ive always loved Behes IDiotic perspective on viruses. You see, bacteria and humans and…

Recombination: Retrovirus Sex

There was a lot wrong with Micheal ‘Lilo‘ Behes description of HIV-1 in last years book, ‘Edge of Evolution‘. There is a lot of discussion in the Evilutionist community as to what constitutes a Creationist, but there are a few mistakes Creationists continually make when trying to argue against evilution, especially regarding ‘mutations’. Despite Lilos…

Paleovirology

Holy crap. Do you guys remember how Per Ahlberg got his big break? He sifted through the fossil collection at the London Natural History Museum, found friggen tetrapod? Someone just did the same thing with HIV-1. Michael Worobey dug through prehistoric (1960s hehe) tissue samples hunting for early HIV-1 sequences. Now by ’tissue samples’ I…

Elite Suppressors

There are two questions I get over and over and over again from friends, family members, readers, etc about HIV-1: 1. Will we ever get a vaccine? 2. How come some people who are infected with HIV-1 never get AIDS, and some people succumb very quickly? Ive already touched on Q1 a couple of times,…

Nice letter from a Creationist

Despite the wackaloon letters PZ gets, Im being serious! It really is nice! I encourage everyone to leave questions in the comments or send me emails if they want to know more about a topic, and I am just as happy to oblige a evilutionist as a Creationist. Especially when theyre nice about it! So…