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Fun! I like this new idea! Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART I havent talked about ‘scFv’ on ERV yet, but theyre very handy tools scientists are taking advantage of more and more these days. ‘scFv’s are single-chain variable fragments… not an overly useful name, but what they are are basically…

HIV-1s ancestors just got older-er

More HIV news! HIVs ancestor, SIV (simian immunodeficiency virus), has been around a LOT longer than we previously thought. As I have mentioned before, we always assumed retroviruses like HIV, lentiviruses, are evolutionarily ‘young’. They are relatively complex, so probably ‘newish’ in retrovirus-world, but they do not fossilize well (we have found very few lentiviral…

The second baby

Holy crap the HIV news last week! So much HIV news! First on the list: Early Treatment Is Found to Clear H.I.V. in a 2nd Baby Just in case you have forgotten, the first baby. What happened to ‘the baby cured of HIV’? Now, the second baby– I must emphasize that I only know what…

‘Cure’ for HIV and HepC in Egypt

It is frustrating being a scientist in a political climate that is not supportive of science. But what we have to put up with in the US pales in comparison with something happening right now in Egypt: More from CNN: Egyptian army’s AIDS-cure claim gets harsh criticism Maj. Gen. Ibrahim Abdel-Atti is apparently a total…

WHY IS THIS NOT STANDARD THERAPY YET? Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia I wrote about this last year: ‘Dismal prognosis’ with leukemia? Nothing a GMO virus cant fix. In the previous study, scientists took cytotoxic T-cells from five B-ALL patients, and infected them with…

GMO retroviruses vs Parkinsons

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson’s disease: a dose escalation, open-label, phase 1/2 trial 1. Start with HIV-1s ‘country cousin‘, Equine Infectious Anemia Virus (EIAV). EIAV is a lentivirus, like HIV, so it is a good gene therapy virus. Lentiviruses are a bit more trustworthy than the gamma retroviruses…

HIV Deniers silence YouTube critic

YouTuber MylesPowers1985 has got an in-depth analysis of  the HIV Denier movie, ‘House Of Numbers’, going. Of the episodes I saw, it is really good. Its not the usual boring ‘person talking to a camera’ video– it is serious investigative journalism. I say ‘of the episodes I saw’ because MylesPowers1985s videos are being taken down by…

What happened to ‘the baby cured of HIV’?

Do you all remember this story from last year? Mississippi Baby Born With HIV ‘Functionally Cured,’ Doctors Say I wrote about it a bit: Wait…Did a kid just get cured of HIV? The sequester and HIV/AIDS But it was hard to say much without a paper. As I was doing some other reading last week,…

If you pay taxes in the US (and many other countries), you are helping fund HIV/AIDS research, including the development of HIV vaccines. This includes my research project, so, YAY! Thank you! What happens, is, we pay taxes. Part of that cash goes to various government agencies to dole out to researchers. When researchers think…

More gene therapy for more kinds of blindness!

This therapy isnt perfect, but its a cool start! Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial ‘Choroideremia‘ is a kind of blindness caused by deletion of a gene called REP1. Because REP1 is on the X-chromosome, there is  no ‘second chance gene’ on the other chromosome in men. They…