ERV

Tag archives for ERV

1– Herpes viruses are old. They are ooooooold. Like, hundreds of millions of years old. Specifically, about 400 million years old. 2– Herpes viruses are everywhere. Fish, reptiles, birds, cows, humans, everywhere. And there are lots of different kinds that humans have to deal with– CMV, EBV, HHV-8, VZV, HSV… 3– And, though herpes viruses should…

Okay, I have written a LOT about the connection between wayward ERV activity and Multiple Sclerosis. This is something scientists have been investigating for a long time… but we still do not know exactly what is going on. It seems the running hypothesis is that ‘something’/’somethings’ alter the epigenetic profile of individuals DNA, allowing for…

Neanderthal and Denisovan retroviruses in YOU!

Well, some of you! And maybe me! Last year, scientists combed through Neanderthal and Denisovian DNA sequences (yeah, those exist!) and found fourteen ERVs that were in Neanderthals and/or Denisovians, but NOT humans. Neandertal and Denisovan retroviruses SUMMARY: Modern humans (Homo sapiens) last shared a common ancestor with two types of archaic hominins, Neandertals and…

ERVs, from three perspectives

I love viruses, and I love ERVs, but I am not the only one Here are some links to pieces people have written about these lovely pirates, from three different perspectives. 1– Nicholas Covington at Humes Apprentice (formerly AIG Busted!) is more a philosopher than a scientist, but even as a ‘layman’, he gets what ERVs…

I have written quite a bit about the connection between wayward expression of an ERV, and Multiple Sclerosis. ERVs and Multiple Sclerosis ERVs and Multiple Sclerosis, #2 ERVs and Multiple Sclerosis, #3 ERVs and Multiple Sclerosis, #4 ERVs and Multiple Sclerosis, #5 I am very comfortable saying there is a connection between ERV expression and MS.…

How the Appaloosa got its leopard spots

I have no idea how the leopard got its spots, but scientists have figured out how horses got their leopard spots! Evidence for a Retroviral Insertion in TRPM1 as the Cause of Congenital Stationary Night Blindness and Leopard Complex Spotting in the Horse Get this! Scientists have known for a few years that it is…

Which came first? The chicken or the blue egg?

After I cleared up everyones confusion on why chicken gonads are lopsided, and why we have white chickens, I thought I would tackle another one of lifes great mysteries. Admit it. Youve wondered where the hell blue chicken eggs come from. I ‘get’ brown eggs. I ‘get’ white, kinda. BUT WHERE THE HELL DID BLUE COME…

This idea… this idea might be absolute genius… Immunogenicity of bivalent human papillomavirus DNA vaccine using human endogenous retrovirus envelope-coated baculoviral vectors in mice and pigs. The ‘best’ vaccines are live attenuated vaccines.  Weakened/Misadapted viruses that can replicate a little bit, and get your immune system to generate a B-cell response (what you get with…

ERMAHGERD! ERVALANCH! ERVs and Placentas

The connection between ERVs and placentas is already well established. Without a shadow of a doubt, the ability of mammals to generate placentas was, in part, accomplished by domesticating an endogenous retroviral env protein.  In humans, we call this protein syncytin, or ERVWE1. This new paper in Nature Genetics takes the ERV-Placenta connection a step…

Here is a nice open access review article on ERVs and their association with cancer: Human endogenous retroviruses and cancer prevention: evidence and prospects While thats wonderfully interesting, what I want to focus on is a bit at the end. More information I have never heard before– An amino acid sequence similar to HERV-K-MEL, recognized…