HIV-1

Tag archives for HIV-1

“HIV mutates a lot”. People ‘get’ that. Why is HIV hard to stop? Why is HIV hard to treat? “HIV mutates a lot”. But HIV does not mutate willy-nilly. It mutates at an evolutionarily defined rate. The reverse transcriptase enzyme makes mistakes during replication that are beneficial to HIV– creating a diverse population, a quasispecies,…

Some of you might remember the waves made earlier this year about ‘The Immunity Project’. They were crowdsourcing an HIV vaccine that was magical and amazing and they were totally going to give it away for free!! YAY! … Except ‘The Immunity Project’ basically had nothing to back their claims up. No publications, the investigators had…

c0nc0rdance + HIV vs Creationists

Though ERVs are my favorite tool vs Creationists, HIV is a fantastic choice as well. I mean, has anyone seen hide or hair of Behe since 2007? Poor guy. Alas, there are still Creationists out there, so to address some of their ‘concerns’, c0nc0rdance made a couple of vids using his favorite HIV protein, Vpr:

Of course, SciBlogs is in the middle of a WordPress update when this news breaks: ‘Mississippi Baby’ now has detectable HIV, researchers find Some of you might remember last year, when there was exciting news about a baby, born with HIV, who had subsequently become HIV- thanks to an alternative treatment strategy (basically, give babby HAART…

Prosecuting faked HIV vaccine results

Remember this? Wait, what? Faked HIV vaccine results The researcher accused of manipulating his reagents to ‘show his HIV vaccine strategy worked’ admitted he did it: Investigators say former Iowa State University laboratory manager Dong-Pyou Han has confessed to spiking samples of rabbit blood with human antibodies to make an experimental HIV vaccine appear to…

Homeopathic HIV ‘infection’

Well, you cant say Brian Dunning doesnt put his money where his mouth is when it comes to his skepticism about homeopathy: I’ve been speaking with lab managers, AIDS researchers, and doctors about my plan to make a documentary short film about drawing blood from an HIV-positive patient, properly making a 30C homeopathic dilution of…

The first and second baby, apparently ‘cured’ of HIV after being infected at birth, lived in the US. In the US, the standard treatment for an at-risk baby is wait for a firm HIV diagnosis before administering HAART. But when Baby #1 and Baby #2 got HAART ASAP, they are functionally ‘cured’ of HIV, and…

A shot to prevent HIV– Maybe.

Long-time readers of ERV know that I am not a fan of Pre-Exposure Prophylactics as a regular means of preventing HIV infection. In tightly controlled clinical trials, giving people who might be exposed to HIV anti-HIV drugs does lower infection rates… but when the same protocol is let loose ‘out in the wild’, the results…

You all might have heard about ‘delta32′ or ‘delta-CCR5′ people in association with HIV infection. People who naturally, by chance, have deletions and mutations in the CCR5 gene of their DNA dont make functional CCR5 proteins. It doesnt appear to be ‘a big deal’, and people who have this particular mutation seem to live normal…

Fun! I like this new idea! Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART I havent talked about ‘scFv’ on ERV yet, but theyre very handy tools scientists are taking advantage of more and more these days. ‘scFv’s are single-chain variable fragments… not an overly useful name, but what they are are basically…