Virology

Tag archives for Virology

WHOOOO!!!!! GMO HSV-1 vs Cancer

WHOOOOOOOO!!!! April 7, 2010: Using HSV-1 to cure metastatic melanoma May 26, 2015: Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma WHOOOOOOOOOOOOOOOO!!!!! They just published the results of Phase III clinical trials of a herpes simplex-1 genetically modified to kill cancers, specifically, advanced melanoma. The GMO virus has a name now: T-VEC. And…

One of my favorite stories is the tale of a GMO virus deployed to treat Hemophilia B: Gene therapy for Hemophilia B … Hemophilia B is a disease in males caused by point mutations/deletions/etc in the clotting Factor IX gene. If you dont make Factor IX, you wont clot properly, and will have all of…

Oh, Sanjay Gupta. Secret serum likely saved Ebola patients (warning: link has auto-play video, ugh) Three top secret, experimental vials stored at subzero temperatures were flown into Liberia last week in a last-ditch effort to save two American missionary workers who had contracted Ebola, according to a source familiar with details of the treatment. There was…

There has recently been (more) discussion about whether the US should destroy its remaining stocks of the smallpox virus: Are We There Yet? The Smallpox Research Agenda Using Variola Virus Like measles, smallpox is a human-only pathogen. There are not bat or pig reservoirs out there– smallpox is only in people. So with effective, world-wide…

If we vaccinated everyone who could be medically vaccinated against measles, measles would be eradicated. Though there are other measles-like viruses, humans are the only hosts for what we commonly refer to as ‘measles’. Use vaccines to cut humans out of the equation? Extinct virus. Its that ‘easy’. Unfortunately, measles ‘wants’ to exist, and they…

CSI: Virology

The best mysteries are ones where the reader, if they are following along carefully, can figure out the answer to the problem as the lead characters do. If you read science blogs and love evolution, then you know exactly where this is headed: Molecular evolution in court: analysis of a large hepatitis C virus outbreak…

Another day, another disease treatment strategy based off a genetically modified virus! Prostate Specific Antigen Retargeted Recombinant Newcastle Disease Virus for Prostate Cancer Virotherapy. This one is so clever, you guys. It is so freaking clever! Some of you might know that sometimes, when prostate cancer is present, there is an elevated level of ‘Prostate…

GMO Cowpox vs liver cancer

This is ridiculous. After all of the papers I have read, written about, the new stuff we can do with GMO viruses…I can still be amazed. This is insane: Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer The patients in this study had liver cancer.  Specifically, malignant hepatocellular carcinoma (HCC).  In…

Ricky Gervais: AIDS vs Rabies

I dont know why he took it down, but Ricky Gervais Tweeted the following a few days ago: Any virologists or medical experts out there? What WOULD win out of AIDS & Rabies? Maybe he took it down because he thought it was insensitive or something, but I think its a totally normal, valid question…

YEAH!!! WARBLEGARBLE KILLER FLU is BACK!!!

YAAAAAAAAAAY!!! You know that ‘killer bird flu’ I talked about at FreeOK2?  Last year some governments FREAKED OUT because scientists evolved a mammal-to-mammal transmissible bird flu in the lab, and the government officials were concerned that The Worlds Stupidest Terrorists would try to use it as a weapon. Somehow. For some reason. Whatever. Finally, despite…