This week’s evolgen Double Entendre Friday is brief. It’s also not my own idea, and I can’t seem to remember where I stole it from (if I stole it from you, drop a note in the comments). Sorry. Here it is:
Two glutamines bump into each other waiting to aminoacylate a tRNA. One says to the other, “I saw you hanging out near that ribosome with your last tRNA. Did you go all the way?” The other replies, “Well, my tRNA got me into the A site, but we were caught pretending to be a histidine. After that, there was no way the ribosome was going to let me get through her exit tunnel.”
Incidentally, one way to study translation is to probe the ribosomal exit tunnel.