The genome encodes all of the RNAs and contains sequences responsible for the transcription of those RNAs and the proper folding and wrapping of the cromosomes. The RNAs encoded by the genome are collectively known as the transcriptome. The transcripts that are translated into proteins represent the proteome or the ORFeome (depending on the context).
I’m fascinated by the growing list of “-omes” out there. Genomics and proteomics appear to be the most established “-omics” disciplines, but a new paper in PNAS has introduced me to an “-ome” with which I was previously not familiar: the allosterome. This represents all of the allosteric interactions in a cell.
Recently, some other grad students and I decided it would be fun to make up our own clever “-omes”. This led to us to making up our new disciplines and clever abbreviations for these made up areas of study. We then dared each other to include these in presentations at the meeting we were attending — with the additional dare that you had to include the new term on a slide without defining it, as if the audience was supposed to be familiar with the moniker. No one accepted the challenge, but a couple of my favorites are listed below:
The genome-ome: This is, obviously, a collection of all the genomes. It can be all the genomes of every ogranism, all the sequenced genomes, all the sequenced genomes of a particular taxon, etc. For instance, here’s a page devoted to the Drosophila genome-ome. This may sound boring, but the fun part is the pronunciation. Genome-ome is pronounced “gee-nome-a-nome”, with the rhythm of manamana. If you feel particularly inspired, you can perform a rendition of the song replacing “manamana” with “gee-nome-a-nome”. Doing this during a presentation with audience participation would be a crowning achievement of any young academic’s career.
Genoinformatics: A quick Google search reveals that we were not the first ones to come up with this. Darn! Anyway, we defined genoinformatics as bioinformatics on genomes. This wasn’t all that remarkable, but then we realized that it sounds kind of like a guy’s name: Gene Informatics. He then became international, with Geno Informatico from Italy, Jean Informatique from France, Jan Informatik from Germany, and Juan Informatica from Mexico. The next step in this plan is to include an acknowledgement of one of these cosmopolitan characters at the end of a talk. Heck, you could probably slip him in as a coauthor on a genome paper.