evolgen

Archives for August, 2007

I’d be remiss to not mention this paper from Hopi Hoekstra’s group after I previously discussed the anti-evo-devo paper she wrote with Jerry Coyne. The premise of the paper from Hoekstra and Coyne is that Sean Carroll overplays the importance of cis-regulatory changes in the evolution of form. Well, Hoekstra and colleagues mapped the genes…

The Not-So-Royal We

Finally, using a series of related MMEJ substrates, we investigated the inhibitory effect of Pku70 on fission yeast MMEJ unraveled in this study and the impact of both length and position of the microhomologous region on MMEJ efficiency. That quote comes at the end of the introduction of this paper entitled “Microhomology-Mediated End Joining in…

Peter Lawrence has an opinion piece in Current Biology on the problems with evaluating scientists, amongst other things. He hits upon a few important points, including journal impact factors, the cost of high risk research, hyping up publications, and networking with the right people to improve your publications. One passage was quite salient given a…

Score One for King & Wilson?

King and Wilson are the bee’s knees for all the kids who want to hype the effect of gene expression divergence between humans and chimps. The argument boils down to a few points: humans and chimps are mad different, their protein sequences are mad similar, therefore expression of the proteins must be important for those…

You Call This a Blog?

Wow, posts at evolgen have been few and far between. A damn, dirty manuscript is to blame. I keep trying to get it write itself, but the sucker refused to oblige. Maybe it would help if I could finish the data analysis. But enough about me. Let’s talk about me Steve Steve. The last time…

Is Sean Carroll Wrong?

One of the primary hypotheses of Sean Carroll’s model of evo-devo is that cis-regulatory elements (CREs) are the primary drivers of morphological evolution (see here). This hypothesis is controversial in the evolutionary genetics community. Because it’s hard to examine the effect of CREs on phenotypes at a genome-wide scale, the problem must be reduced into…