My series on using computational tools to study molecular evolution [Publishing Original Research on Blogs] has focused on the evolution of the aldolase gene family in Drosophila. When I described the Backstory, I left out a lot of details regarding the biochemistry of glycolysis. Well, Larry Moran happens to be a biochemist — he’s even written a book about biochemistyr — and he’s posted a more comprehensive look at aldolase. I focused my introduction on animals, which use aldolase in glycolysis — the breakdown of glucose into smaller molecules. Larry points out that the opposite pathway (gluconeogenesis) uses a different version of aldolase in the production of glucose.