Genomics

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Category archives for Genomics

Is it just me or does every analysis that looks for over-represented gene ontology (GO) terms turn up transcription factors? It doesn’t matter if the study is looking for genes under positive selection or something else. It just seems like transcription factors are enriched in every dataset.

Make that 12 Drosophila Genomes

What happens when I mention a paper describing two more Drosophila genomes? Well, I get a comment telling me that the 12 Genomes Papers have gone live over at Nature. They have provided a nifty 12 Genomes Portal for us to navigate the articles published by Nature based on data from the 12 Genomes Project.…

Two More Drosophila Genomes

The world of genomics is changing. It was initially about sequencing the genome a single representative individual from a particular species. Now, there’s a large focus on polymorphism — that is, sequencing multiple individuals from a single species to study the genomic variation in that species. That’s well under way in humans, with HapMap and…

Previous entries: Part 1 – Introduction Part 2 – The Backstory Part 3 – Obtaining Sequences Part 4 – Obtaining More Sequences Part 5 – Examining the Outgroups This post is part of a series exploring the evolution of a duplicated gene in the genus Drosophila. Links to the previous posts are above. Part 6…

Previous entries: Part 1 – Introduction Part 2 – The Backstory Part 3 – Obtaining Sequences Part 4 – Obtaining More Sequences This post is part of a series exploring the evolution of a duplicated gene in the genus Drosophila. Links to the previous posts are above. Part 5 of this series (Examining the Outgroups)…

Frank Wants a Shiny Prize

Please God, don’t let it happen. Please don’t let Franky Collins win this stupid award. I don’t usually make pleas to you, but, given that this is a matter regarding a man of faithTM, I figured it’s a good time to plea to the sky fairy. So, do whatever you can to prevent Congress from…

Previous entries: Part 1 – Introduction Part 2 – The Backstory Part 3 – Obtaining Sequences This post is part of a series exploring the evolution of a duplicated gene in the genus Drosophila. Links to the previous posts are above. Part 4 of this series (Obtaining More Sequences) can be found below. Obtaining More…

Previous entries: Part 1 – Introduction Part 2 – The Backstory This post is part of a series exploring the evolution of a duplicated gene in the genus Drosophila. Links to the previous posts are above. Part 3 of this series (Obtaining Sequences) can be found below. Obtaining Sequences In the previous post I described…

Publishing Original Research on Blogs – Part 1

This is a repost (with some edits) of an introduction to publishing original research on blogs — a series I am reintroducing. The original entry can be found here. In April of last year, Bora pushed the idea of publishing original research (hypotheses, data, etc) on science blogs. As a responsible researcher, I would need…

Multicellular Eukaryotic Genomes are Teh Suck

The human genome is one big, bloated motherfucker. It’s almost all non-protein-coding DNA. The same is true for many other eukaryotic genomes. Sure, some of it has a function. But a whole lot of it (and maybe most of it) is just junk. There are some who point to a relationship between genome size and…