cancer

Genetic Future

Category archives for cancer

I’ll be spending the next few days at the Biology of Genomes meeting at Cold Spring Harbor, NY – one of the most awaited events on the genomics calendar. I plan to blog here about the major themes emerging from the meeting; you can also follow me on Twitter if you want shorter, punchier updates,…

Jones et al. (2009). Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene. Science DOI: 10.1126/science.1171202 A paper published online today in Science illustrates both the potential and the challenges of using large-scale DNA sequencing to identify rare genetic variants underlying disease risk. Traditionally, geneticists have pinned down such variants using large family studies.…

Steve Murphy is up in arms about a recent email from 23andMe to its customers advertising the use of genetic variants on its V2 chip to predict individual risk of statin-induced myopathy and breast cancer. Of course, Steve does have a strong financial interest in 23andMe staying as far away as possible from the area…

Over at PolITiGenomics, Washington University’s David Dooling discusses his work as part of the Tumor Sequencing Project. The TSP and a variety of other groups (like The Cancer Genome Atlas) are using large-scale sequencing to create comprehensive maps of the genetic changes that underlie cancer formation. The cancer genome sequencing community have already made impressive…