genetics of normal variation

Genetic Future

Category archives for genetics of normal variation

A paper just released in the Lancet describes a thorough and integrated approach to squeezing as much clinically relevant information as possible out of a genome sequence. However, despite a state-of-the-art clinical interpretation pipeline, the major message from the paper is just how far we still have to go before we can make full use…

Medland et al. (2009). Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans. The American Journal of Human Genetics DOI: 10.1016/j.ajhg.2009.10.009 A couple of weeks ago I reported on a presentation by 23andMe‘s Nick Eriksson at the American Society of Human Genetics meeting in Honolulu, in which Eriksson presented data on a…

It’s been an intensive week of genomics here at the American Society of Human Genetics meeting, and I haven’t been able to grab time to blog as much as I’d have liked. In fact there’s a whole load of genomics news I’ll be trying to cover in some detail over the next couple of weeks;…

CNN reports: At the Chongqing Children’s Palace, experts are hoping to revolutionize child-rearing with the help of science. About 30 children aged 3 to 12 years old and their parents are participating in a new program that uses DNA testing to identify genetic gifts and predict the future. The test is conducted by the Shanghai…

Cho, Y., Go, M., Kim, Y., Heo, J., Oh, J., Ban, H., Yoon, D., Lee, M., Kim, D., Park, M., Cha, S., Kim, J., Han, B., Min, H., Ahn, Y., Park, M., Han, H., Jang, H., Cho, E., Lee, J., Cho, N., Shin, C., Park, T., Park, J., Lee, J., Cardon, L., Clarke, G., McCarthy,…

GenomeWeb Daily News points to a new funding opportunity from the US National Institutes of Health (NIH) for researchers interested in studying the link between genetic variants and variation in the expression levels of genes. This is an incredibly important area of research. Genome-wide association studies have recently uncovered vast numbers of DNA regions linked…

Neuroscientists Sam Wang and Sandra Aamodt have a guest post on Olivia Judson’s NY Times blog discussing the complex interplay between genes and environment in the determination of personality traits. A taste: So some of the effects that we call “genetic” (or “nature”) are the indirect result of people being drawn to particular environments because…

I posted a while back on two duelling essays in Nature on the intensely controversial subject of whether scientists should be permitted to study group differences in cognition. Nature now has a series of correspondence on the topic in its latest issue. Firstly, there are rebuttals from the authors of the two original essays: Steven…

Fan Liu, Kate van Duijn, Johannes R. Vingerling, Albert Hofman, AndrĂ© G. Uitterlinden, A. Cecile J.W. Janssens, Manfred Kayser (2009). Eye color and the prediction of complex phenotypes from genotypes Current Biology, 19 (5) DOI: 10.1016/j.cub.2009.01.027 In a recent post I noted that genetic tests to predict adult height are still a long way off…

Yurii S Aulchenko, Maksim V Struchalin, Nadezhda M Belonogova, Tatiana I Axenovich, Michael N Weedon, Albert Hofman, Andre G Uitterlinden, Manfred Kayser, Ben A Oostra, Cornelia M van Duijn, A Cecile J W Janssens, Pavel M Borodin (2009). Predicting human height by Victorian and genomic methods European Journal of Human Genetics DOI: 10.1038/ejhg.2009.5 Human height…