risk prediction

Genetic Future

Category archives for risk prediction

As part of his Gene Week celebration over at Forbes, Matthew Herper has a provocative post titled “Why you can’t have your $1000 genome“. In this post I’ll explain why, while Herper’s pessimism is absolutely justified for genomes produced in a medical setting, I’m confident that I’ll be obtaining my own near-$1000 genome in the…

Late last week I stumbled across a press release with an attention-grabbing headline (“The Causes of Common Diseases are Not Genetic Concludes a New Analysis“) linking to a lengthy blog post at the Bioscience Resource Project, a website devoted to food and agriculture. The post, written by two plant geneticists, plays a tune that will…

Genetic genealogist Blaine Bettinger has a fantastic post dissecting and contextualising a rather worrying result from his personal genomic analysis: a 50-60% increased lifetime risk of type 2 diabetes. Blaine is unfortunate enough to be among the 1-2% of individuals who carry two risky versions at each of three major risk variants for the disease.…

Late last week I noted an intriguing offer by personal genomics company deCODEme: customers of rival genome scan provider 23andMe can now upload and analyse their 23andMe data through the deCODEme pipeline.  On the face of it that’s a fairly surprising offer. As I noted in my previous post, interpretation is what generates the real…

Four scientists – including the omnipresent J. Craig Venter (left) – have penned an opinion piece in the latest issue of Nature based results from five individuals genotyped by two separate personal genomics companies. The article highlights some deficiencies in the way that genetic data are currently used by direct-to-consumer companies to generate risk predictions and…

Mihaescu, R., van Hoek, M., Sijbrands, E., Uitterlinden, A., Witteman, J., Hofman, A., van Duijn, C., & Janssens, A. (2009). Evaluation of risk prediction updates from commercial genome-wide scans Genetics in Medicine, 11 (8), 588-594 DOI: 10.1097/GIM.0b013e3181b13a4f Caroline Wright from the Public Health Genomics Foundation has a concise post describing the results from a recent…