whole-genome sequencing

Genetic Future

Category archives for whole-genome sequencing

Pushkarev, D., Neff, N., & Quake, S. (2009). Single-molecule sequencing of an individual human genome Nature Biotechnology DOI: 10.1038/nbt.1561 Yes, it’s yet another “complete” individual genome sequence, following on the heels of Craig Venter, James Watson, an anonymous African male (twice, and not without controversy), two cancer patients, a Chinese man, and two Koreans.  There is a…

While I continue my work-induced blog coma, here’s a guest post from Luke Jostins, a genetic epidemiology PhD student and the author of the blog Genetic Inference, delivering a fairly scathing critique of a recent whole-genome sequencing paper based on Life Technologies’ SOLiD platform. McKernan et al. 2009. Sequence and structural variation in a human…

Harvard biostatistician Peter Kraft (co-author of an excellent recent article on genetic risk prediction in the New England Journal of Medicine) has just added an interesting comment on his experience of this week’s Consumer Genetics Show:

The buzz leading up to this week’s Consumer Genetics Show in Boston suggested that a major announcement would be made by the CEO of genomics technology provider Illumina, Jay Flatley. Illumina provides the most popular second-generation sequencing instrument currently on the market, the Genome Analyzer II, and has been making noises about moving into the…

The Personal Genome Project, an initiative founded by George Church that ultimately seeks to sequence the complete genomes of 100,000 people, has called for the next wave of volunteers. The PGP will sequence your genome and give you back the data for the bargain-basement price of zero dollars (not bad compared to the $68,000 that…

The auction of a whole-genome sequencing service that I scoffed at a few days ago is now live on eBay – serious bidders only, please, and bids start at $68,000. Here’s what you get for your suitcase of cash: Personal whole genome sequencing and comprehensive interpretation of your genome. Knome’s proprietary KnomeXplorerâ„¢ genome browser software…

Personal genome sequencing provider Knome is planning to offer a complete genome sequence to the highest bidder on eBay – with the bidding opening at $68,000. The plan, announced in an NY Times article today, is described as “essentially a publicity stunt” – the proceeds will be donated to the X Prize Foundation, a charitable…

I wrote a few days ago about a debate in the New England Journal of Medicine over the value of data emerging from recent genome-wide studies of the role of genetic variation in common human diseases and other traits. David Goldstein argued that genome-wide association studies (GWAS) have generated disappointing results, and should be scaled…

A reader pointed me to a recent Economist article on personal genomics. There are numerous tidbits of interest, such as a passing comment about the chaotic Chinese personal genomics industry (about which I know almost nothing). Perhaps the most important quote comes in the closing paragraph: Dr Church even argues that genome sequencing “will in effect…

GenomeWeb News reports that genome sequencing company Complete Genomics is cutting costs in the lead-up to the commercial launch of its whole-genome sequencing service in June: In order to save its remaining cash, the company recently implemented “a variety of cost-saving measures,” including “some reductions” in the salaries of its employees and a trimming of…