genome-wide association studies:
Category: ashg2009
Personal genomics company 23andMe presented today at the American Society of Human Genetics meeting on novel genetic associations generated by the company using data from their customer base. The presentation showed that the company is capable of doing solid science, although it also raised worrying questions about the validity of survey results from customers who've already seen their genetic data.
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Posted by Daniel MacArthur at 5:30 AM • 10 Comments •
Category: personal genomics
Details are pretty sketchy, but a press release announced today suggests that personal genomics company 23andMe has performed a genome-wide association study comparing 100 current or former professional NFL players with a set of controls of unspecified sample size.The...
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Posted by Daniel MacArthur at 12:30 PM • 23 Comments •
Category: guest post
Guest post: Neil Walker provides some insight into a recent and rather bizarre Nature paper exploring the genetic basis of schizophrenia.
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Posted by Daniel MacArthur at 8:00 AM • 9 Comments •
Category: genome-wide association studies
Genomic analysis technology provider Illumina has launched a new range of genotyping chips, designed to capture information about 4 million genetic variants scattered throughout the genome - four times more markers than the previous generation of chips. However, will more markers necessarily provide greater power for genome-wide association studies?
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Posted by Daniel MacArthur at 7:00 PM • 4 Comments •
Category: genome-wide association studies
A common genetic variant is reported in Nature as being associated with an increased risk of autism - but the effects on disease risk are modest, consistent with a generally disappointing yield for studies of common variants in psychiatric diseases.
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Posted by Daniel MacArthur at 5:35 PM • 8 Comments •
Category: genome-wide association studies
A large Korean study takes a detailed look at the genetic variants associated with 8 different complex traits - and provides an intriguing insight into the differences in the genetic architecture of variable traits between human populations.
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Posted by Daniel MacArthur at 11:00 AM • 0 Comments •
Category: disease genetics
There are perfectly valid debates going on about the best direction for future research into the genetic basis of common diseases; that doesn't mean that all the money spent so far on such research has been wasted.
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Posted by Daniel MacArthur at 7:45 AM • 4 Comments •
Category: genome-wide association studies
A series of articles in the New England Journal of Medicine provide very different views of the results of the last few years of research into common disease genetics.
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Posted by Daniel MacArthur at 8:45 PM • 19 Comments •
Category: genetics of normal variation
A recent paper shows that, despite massive genome-wide association studies, height predictions using known genetic markers are still far less accurate than those using parental height alone.
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Posted by Daniel MacArthur at 7:30 AM • 21 Comments •
Category: agbt
Highlights from the Advances in Genome Biology and Technology meeting, including a credible report of a genetic region associated with a love of crossword puzzles - at least in Icelanders.
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Posted by Daniel MacArthur at 7:45 PM • 4 Comments •
