whole-genome sequencing:
Category: complete genomics
Sequencing provider Complete Genomics is partnering with the Institute for Systems Biology to sequence the entire genomes of 100 individuals, in an attempt to uncover the genetic basis of variation in the presentation of Huntington's disease. This is the first ever attempt to use whole genome sequencing for complex trait association, but there will be dozens more announced over the coming months - so what are the major challenges that lie ahead?
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Posted by Daniel MacArthur at 7:30 AM • 5 Comments •
Category: next-generation sequencing
The announcement that IBM is entering the DNA sequencing race has created media excitement, but as yet there's nothing to suggest that IBM is a serious competitor to better-established platforms such as Oxford Nanopore.
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Posted by Daniel MacArthur at 11:00 AM • 3 Comments •
Category: next-generation sequencing
Two interviews in Bio-IT World shed light on the rapidly evolving world of new sequencing technology, and the informatic challenges created by that evolution.
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Posted by Daniel MacArthur at 7:00 AM • 4 Comments •
Category: next-generation sequencing
Sequencing company Illumina has delivered its first commercial personal whole genome sequence to entrepreneur Hermann Hauser.
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Posted by Daniel MacArthur at 5:30 AM • 6 Comments •
Category: next-generation sequencing
Complete Genomics, the company that promises complete human genome sequences for $5,000, has finally received the funding it needed to construct its first commercial facility in Silicon Valley. I talked to the company's CEO and one of its directors about the company's goals over the next 18 months.
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Posted by Daniel MacArthur at 8:00 AM • 4 Comments •
Category: next-generation sequencing
The widely-reported "price drop for genome sequencing" due to third-generation sequencer Helicos is an illusion.
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Posted by Daniel MacArthur at 8:00 PM • 2 Comments •
Category: next-generation sequencing
Stephen Quake, co-founder of DNA sequencing start-up Helicos, has sequenced his own genome using the company's single-molecule sequencing technology - but we still haven't reached the cost and accuracy points required to trigger a revolution in human genome sequencing.
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Posted by Daniel MacArthur at 7:00 PM • 7 Comments •
Category: guest post
Luke Jostins of Genetic Inference critiques a recent paper in Genome Research showcasing the first published human genome sequence generated using SOLiD technology.
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Posted by Daniel MacArthur at 8:45 AM • 17 Comments •
Category: incidentalome
The "incidentalome" is the collective term for the genetic findings of uncertain medical significance that will emerge in the era of whole genome sequencing. Does the danger of swamping the medical system with spurious findings justify restrictions on access to genetic information?
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Posted by Daniel MacArthur at 3:10 PM • 6 Comments •
Category: next-generation sequencing
Sequencing giant Illumina today announced a new foray into the world of personal genomics, launching a whole-genome sequencing service that halves the price of its nearest competitor - but still leaves the genome out of reach for most of us.
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Posted by Daniel MacArthur at 6:30 AM • 13 Comments •
