Gene Expression

Dan MacArthur at Genetic Future has the details. Some of the stuff coming out of genomics reminds me a lot of what you see with social science; lots of sexy studies which turn out not to be as significant upon later analysis. Perhaps hypotheses are overrated?

Comments

  1. #1 Daniel MacArthur
    March 31, 2008

    Perhaps hypotheses are overrated?

    Well, some of the people doing genome scans would argue that they’re going in without any hypothesis at all.

    Of course, the hypothesis they’re implicitly testing is that common diseases are caused by common variants that can be tagged with a SNP chip; as it turns out, this hypothesis is largely wrong.

  2. #2 Marcus
    April 5, 2008

    Of course, the hypothesis they’re implicitly testing is that common diseases are caused by common variants that can be tagged with a SNP chip; as it turns out, this hypothesis is largely wrong

    How do you know they are wrong?