Gene Expression

Environment as the gene’s handmaid

A few days ago The New York Times had a blog post up which addressed the relationship between genes & environment in shaping our behavior & choices (see Genetic Future). One of the authors even posted a follow up comment where they evinced some surprise at the bile of the responses. I have to say that some people are naive; statistical sciences are a good reflection of the tenor of society. If you say a trait is 50% heritable, that is a statement of fact, but individuals will “spin it” however they want to based on their own outlook and the preferences of their target audience. Years ago Steven Pinker recounted to Robert Wright that when he states that a trait is 50% heritable he is often accused of being a genetic determinist, even though it is a logical implication of his assertion that 1/2 of the variation in the population is due to non-heritable factors. In fact a regular reader of this weblog labeled me as a “genetic determinist” years ago (on his deleted weblog, so I can’t link to the exchange) when I suggested that only 50% of variation in religiosity was due to environment (since he held that 100% was due to environment, he was of course an environmentalist).

There are obvious gross social and political reasons why people are uncomfortable with the idea that a large amount of psychological variation, and therefore a large portion of life outcomes which we implicitly use to measure the worth of a man, are due to variation in genes. Steven Pinker covers the topic in depth in The Blank Slate, so I won’t belabor it. But a more fundamental disquiet probably has to do with our intuition that Free Will exists, and that there is an animating ghost in the machine which has final executive control (even if you are an atheist who rejects the ghost in the machine intellectually, on a deep cognitive level you probably don’t). Of course models predicated only on environmental inputs can remove Free Will from the equation as well, so the issue is less about the heritability of a trait than the fact that one might be able to predict outcomes with a high degree of certitude.

These debates always hinge around the preconception of “Nature vs. Nurture.” This is rather like beginning a discussion of physics by sagely noting the theories propounded by Aristotle. In my 7 years of blogging it is obvious that it is almost impossible to erase from the minds of most that 50% heritability entails 50% of “it” is due to genetics and 50% of “it” is due to environment. 50% heritability simply means that one can adduce that 1/2 of the variation of the trait within the population is controlled by variation of genes, while the other 1/2 is not.* The standard intuition which humans begin with is simply not even wrong.

Terms like heritability only make sense in a specific environmental context. The reason that height is more heritable in the West than in Africa is not because of some different of genetic architecture, rather, the environmental component of variation (nutritional inputs) that is irrelevant in the West remains relevant in Africa. One could imagine that total phenotypic variance in a deprived Third World country would be greater (because of a larger number of individuals who are physically stunted), but the proportion of the variance that was genetic, and heritable, would be lower. But obviously this does not speak to any given person, we are addressing the level of a population (though population level analyses do say something about individuals at the end of the day). Even if someone is stunted because they are starved, a necessary precondition to their growth are a set of genes which express and trigger a sequence of development. Conversely, even in environments of nutritional plenty obviously growth is contingent upon eating food, even if the variation of that consumption is now no longer of any importance in prediction of the variation of the trait.

Though all this is straightforward, sometimes the concepts of gene-environment interaction and gene-environment correlation are not. The easy one first:

You see here two things:

1) The same genotypes in both environments

2) Which react differently to the two environments

If all genotypes react in the same way to an environment shift then there isn’t gene-environment interaction. If you can for example predict the quantitative position of a trait with respect to the mean value across as you shift the environment equally there isn’t an interaction parameter you need to worry about. As an example, imagine that a mean height for males is 68 inches with 3,000 calories per day with a normal distribution (+/- 2.5 standard deviation), and 60 inches with 1,000 calories (+/- 2.5 standard deviation), and all of the average genotypic values remain the same in terms of standard deviation units from the mean.

That is rather straightforward, a confused scramble, but an honest one. Gene-environment correlation is more interesting (to me) and perhaps more sinister. Gene-environment interaction can be thought of as a wild card, putting a cloak of mystery over ultimate outcomes due to the vicissitudes of the universe. It is in this way an aid to the idea of Free Will, as the variables which load the die are harder to tease apart. In contrast, gene-environment correlation exhibits a more regular pattern, tending to take a propensity and amplifying it. In other words where genes determine the direction of the vector the correlation can amplify the magnitude.

Imagine for example a child who is mildly above average in athletic ability and one who is mildly below. Assume that these differences, due to variation in eye-hand coordination, quickness, body fat percentage, etc., are greatly controlled by genes. Nevertheless the traits are only of modest difference in absolute terms during their early years. But as these individuals grow and mature, and select from a range of extracurricular activities, one would presume that they would seek those tasks to which they are suited by their ability to attain virtuosity and avoid those which they are not. Athletic endeavors are such that practice improves skills over time, and the cumulative effect is definitely significant. Environment, learning, practice, etc. does make a difference, but the choices one makes are often strongly conditioned by one’s genetic makeup, leading to a correlation which can multiply small initial differences and eventually lead to a yawning chasm.

So why is this sinister? From The New York Times:

The interaction between genetic tendencies and life experiences may explain another puzzling finding: the heritability of many psychological traits — from intelligence to anxiety — increases as people mature. This result seems odd at first glance, since genes are most important in brain development in babies and children. But children also have less control over their environment than adults. As people get older, they become more able to determine their own circumstances, and they may be able to choose environments that reinforce their natural personality tendencies. Apparently those of us who suspect we are turning into our parents as we get older may have a valid point.

One finding from behavior genetics is that adoptive parents can make a difference, but that the difference often diminishes a great deal after a child leaves the home (the extent of this varies by trait). This makes natural sense. Once the guardrails are gone one’s natural inclinations come to the fore. The sinister part is that this sort of dynamic makes a social engineer’s life rather difficult. To shift the life choices of a subculture one may have to apply coercive or incentive pressure indefinitely barring a change in the underlying genotype. In the most extreme cases of psycopaths and sociopaths punitive measures (specifically their threat) may be the only way society can change behavior or outcome, but behavioral economics and its allied fields tell us that the modal human also has a strong propensity for irrational or self-destructive behavior.

Utopian attempts to change behavior or eliminate social differences have often failed. Most recently in the Kibbutz movement, more generally in Utopian movements as a whole. On the other hand there have been some modest successes, e.g., the reduction in drinking in Scandinavia and the United States since the 19th century through a combination of regulation, taxation and moral suasion. Though there are limits, there are also possibilities.

Like biology, it seems likely that in the social sciences history has not ended. Our common biological heritage is certainly of interest, but individual differences are also important. We may pretend that our liberal order is predicated on some non-aggression principle where we do as we wish so long as there are no victims, but that is an obvious fiction, social norms remain strong, and some are enforced by legal sanction. The gene-environment correlation means that guardrails will be necessary, and that a particular segment of the population will enshrine their own dispositions into social norms and laws which shape the contours of those guardrails for the poor souls whose nature wars against the will of the deciders. Science may not only strip away our belief in Free Will, but may render naked the conceit that man is governed by a Social Contract contingent upon a universal human nature.

Note: Born That Way: Genes, Behavior, Personality and The Nurture Assumption are very good reads on the topic of behavior genetics.

* I oversimplify here, but I would rather not get into narrow vs. broad sense, or whether epistatic variance is collapsed into environmental.

Comments

  1. #1 Sandgroper
    March 27, 2009

    Sylvia Plath was bipolar. It brings to mind another famous bipolar suicide, Virginia Woolf. Both had reason for unhappiness about their personal circumstances. It is interesting, while sad, to contemplate the interaction between genes and environment that led both of them to that point. I don’t know of Sylvia Plath’s son’s circumstances, but it would not be surprising to find that history had repeated itself in some sense.

    I presume that some of those commentors who reacted angrily to the article read it as, in effect, saying that if bad stuff happens to you, it is because your own personality led you to it, i.e. you did it to yourself, you made yourself a victim. Well, to some extent, in a lot of cases, that is undoubtedly true, but by the same token it might suggest that people lack an element of choice about victimhood, which is not true.

    I once had the opportunity to discuss pretty much this topic with a behavioural psychologist, who said that you can’t change your personality, and it is dangerous to try, but that you obviously can change your behaviour. By extension, you can at least to some extent also exercise choice over your environment.

  2. #2 deadpost
    March 27, 2009

    I never understood why even though most people hate the notion that they are “being controlled”, they like the idea that they are being controlled by social engineers better than the idea that they are being controlled by their own genes.

    If people value individualism, wouldn’t they prefer an explanation by the latter. At least it’s “their own genes”.

    As you mentioned, heretibility increases with age because people are more free to choose what feels “natural” to them. At least it’s “my genes”, and no matter how much you try society, you can’t change me!

  3. #3 deadpost
    March 27, 2009

    Is what I said reasonable, or does no individuals with neurotypical folk psychology really think this counter-conventional way…

    “My genes are me, therefore I have more control if its “my” genetics deciding not environment, it’s better that I choose, not society choosing for me.”

  4. #4 tbell
    March 27, 2009

    Extremely interesting. I’d also like to think about what other mechanisms, in addition to seeking out different environments, could magnify, or alter the degree of heritability over the course of the lifespan. Couldn’t it be the case that with old age, phenotypic differences are heightened because some of the redundancies of a homeostatic system are lost? For example if I have one ‘bad’ set of alleles influencing a particular trait, and there are several other contributing factors on that trait that tend to keep it in balance, if these other things break down in function with aging, the influence of the ‘bad’ set of alleles may become unmasked. I’m not sure whether there are analogous situations during child development.

    I’m starting to do some thinking and reading in this area myself, and would love any input or refs people might have.

  5. #5 lol
    March 27, 2009

    z, you’re right. something about intuitive moral philosophy doesn’t jive with an intuitive understanding of heritability and causation.

    somehow all that survives that translation is “the weak deserve their fate”.

  6. #6 nonuthin
    March 27, 2009

    Whether it’s genes or environment, or a remarkably improbable 50-50, it certainly doesn’t look like free will to me.

    And I’m personally O.K. with that, since determinism, at least to my way of thinking, looks a lot like god to an atheist.

  7. #7 Cogsys
    April 2, 2009

    Determinism just means you can predict something, which seems like one of the most useful forms of cognition (in a free market society).

    In contrast, most people seem relatively confined to normative thought. Maybe they like it so much because it gives them the illusion that they’re influencing society, fighting some never-ending cultural war, and their happiness depends on that illusion since they’re collectivists.

  8. #8 Cogsys
    April 2, 2009

    Tbell,

    It seems like many genes that influence our personality do so through influencing the shape of our brain during development, so it seems like changing these genes in an adult might be too late.

    The tissue in the brain is already in place in a certain architecture.

    In that case, maybe treatment for adults moves to the realm of neuroscience rather than genetics.

  9. #9 Ikram
    April 2, 2009

    That commentor is wishing that old exchange was still around. As I recall, you attributed your own irreligiosness to genetics, quoting the 50% variation in heritibility figure. I took issue with you applying a population level concept (heritibility) to an individual — you.

    And called you a genetic determinist for doing so.

    Tis’ always the fate of commentors to have their words twisted and maligned by ungrateful bloggers.

  10. #10 Brandon
    April 15, 2009

    If the concept of free will is made obsolete by evidence of heritability as the main factor in determining our behavior perhaps society needs to become more tolerant and sympathetic of those who do not “measure up.” Those who can’t hold a job, social misfits, those who commit crimes. It’s not as simple as “trying harder” to be a better person.

    Also, I wonder if the evolution of societies as a whole, not just individual differences, can be explained by heritable factors. Could Europe’s success in intellectual pursuits and it’s prosperity, and Subsaharan Africa’s compartive lack of contribution to the sciences and it’s relative poverty be explained by biological factors in the individuals which populate these regions of the world.

  11. #11 Brandon
    April 16, 2009

    The concept of heritability trumping free will and the interaction between our heritability and enviroment can be further examined using Quantum Multiverse Theory. This derivative of multiple universe theory, which has been neither proven nor disproved, argues that for every moment in time (every minuscule movement of every atom) the universe branches off into multiple copies for every possible scenario or possible way the universe can be. For example if one were to roll a six-sided die, the universe would branch off into six copies, one for each outcome. These alternate universes occupy the same physical space as our universe, but are suspended in the abstract realm of multiple dimensions.

    On an individual level, quantum theory states that random quantum processes in our brain control our actions. For every possible way our neurons can fire in reaction to our environment, that are in accordance with the physical laws which control how our brain works and in accordance with our brain structure, the universe branches off into multiple copies.

    Therefore, our actions could be controlled completely by random quantum processes which govern both our brains activity and our environment independent of human intervention, in accordance with the laws of nature.

    If one believes that the Koran preaches that we are predetermined and that there is only one world, one must question the preceding theory. Perhaps everything that every was, is, and will be in the human world follows a linear path determined by our neurological activity acting in reaction to our environment. In this way we are simply “reaction machines” whose subjective experience is an illusion and we are simply agents of God’s divine will.

    In this way, what the Koran describes as our souls are imprinted into our genes and therefore also on our brain’s biology, which is modified by our experience of our environment, which has been created by a series of consecutive non-random reactions.

  12. #12 Rafael Lopez
    May 31, 2009

    I believe genes only make a path that we follow because is easier. However,we can choose to use our intellect to explore the wilderness of our intellect and by doing that start opening a new path for our descendant to choose to walk on.